Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells

R Larsen, N Sandhu, N H H Heegaard, H Ullum, J H von Stemann, E Sørensen, D S Nellemann, M B Hansen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

It would be desirable to be able to distinguish fever as a result of febrile non-haemolytic transfusion reactions (FNHTR) from other febrile conditions. To further characterize the inflammatory feature of FNHTR, we measured a large panel of inflammatory markers in pre- and posttransfusion plasma samples from patients with and without FNHTR following the transfusion of leucoreduced red blood cells. As FNHTR patients only displayed a significant increase in IL-6, we conclude that changes in plasma cytokine levels during FNHTR are unlikely to be used diagnostically. An incidental finding of a distinct cytokine pattern in pretransfusion samples from FNHTR patients warrants further investigations, as it might be used to characterize the nature of FNHTR and to predict the risk of these adverse events.

Original languageEnglish
JournalVox Sanguinis
Volume113
Issue number1
Pages (from-to)76–79
ISSN0042-9007
DOIs
Publication statusPublished - Jan 2018

Fingerprint

Transfusion Reaction
Erythrocyte Transfusion
Interleukin-6

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers/blood
  • Blood Transfusion
  • Case-Control Studies
  • Cytokines/blood
  • Female
  • Fever/blood
  • Humans
  • Male
  • Middle Aged
  • Transfusion Reaction/blood
  • Young Adult

Cite this

Larsen, R., Sandhu, N., Heegaard, N. H. H., Ullum, H., von Stemann, J. H., Sørensen, E., ... Hansen, M. B. (2018). Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells. Vox Sanguinis, 113(1), 76–79. https://doi.org/10.1111/vox.12607
Larsen, R ; Sandhu, N ; Heegaard, N H H ; Ullum, H ; von Stemann, J H ; Sørensen, E ; Nellemann, D S ; Hansen, M B. / Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells. In: Vox Sanguinis. 2018 ; Vol. 113, No. 1. pp. 76–79.
@article{24672e665b5b4fa6bd8759afd615d932,
title = "Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells",
abstract = "It would be desirable to be able to distinguish fever as a result of febrile non-haemolytic transfusion reactions (FNHTR) from other febrile conditions. To further characterize the inflammatory feature of FNHTR, we measured a large panel of inflammatory markers in pre- and posttransfusion plasma samples from patients with and without FNHTR following the transfusion of leucoreduced red blood cells. As FNHTR patients only displayed a significant increase in IL-6, we conclude that changes in plasma cytokine levels during FNHTR are unlikely to be used diagnostically. An incidental finding of a distinct cytokine pattern in pretransfusion samples from FNHTR patients warrants further investigations, as it might be used to characterize the nature of FNHTR and to predict the risk of these adverse events.",
keywords = "Adult, Aged, Aged, 80 and over, Biomarkers/blood, Blood Transfusion, Case-Control Studies, Cytokines/blood, Female, Fever/blood, Humans, Male, Middle Aged, Transfusion Reaction/blood, Young Adult",
author = "R Larsen and N Sandhu and Heegaard, {N H H} and H Ullum and {von Stemann}, {J H} and E S{\o}rensen and Nellemann, {D S} and Hansen, {M B}",
note = "{\circledC} 2017 International Society of Blood Transfusion.",
year = "2018",
month = "1",
doi = "10.1111/vox.12607",
language = "English",
volume = "113",
pages = "76–79",
journal = "Vox Sanguinis",
issn = "0042-9007",
publisher = "Wiley-Blackwell",
number = "1",

}

Larsen, R, Sandhu, N, Heegaard, NHH, Ullum, H, von Stemann, JH, Sørensen, E, Nellemann, DS & Hansen, MB 2018, 'Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells', Vox Sanguinis, vol. 113, no. 1, pp. 76–79. https://doi.org/10.1111/vox.12607

Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells. / Larsen, R; Sandhu, N; Heegaard, N H H; Ullum, H; von Stemann, J H; Sørensen, E; Nellemann, D S; Hansen, M B.

In: Vox Sanguinis, Vol. 113, No. 1, 01.2018, p. 76–79.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells

AU - Larsen, R

AU - Sandhu, N

AU - Heegaard, N H H

AU - Ullum, H

AU - von Stemann, J H

AU - Sørensen, E

AU - Nellemann, D S

AU - Hansen, M B

N1 - © 2017 International Society of Blood Transfusion.

PY - 2018/1

Y1 - 2018/1

N2 - It would be desirable to be able to distinguish fever as a result of febrile non-haemolytic transfusion reactions (FNHTR) from other febrile conditions. To further characterize the inflammatory feature of FNHTR, we measured a large panel of inflammatory markers in pre- and posttransfusion plasma samples from patients with and without FNHTR following the transfusion of leucoreduced red blood cells. As FNHTR patients only displayed a significant increase in IL-6, we conclude that changes in plasma cytokine levels during FNHTR are unlikely to be used diagnostically. An incidental finding of a distinct cytokine pattern in pretransfusion samples from FNHTR patients warrants further investigations, as it might be used to characterize the nature of FNHTR and to predict the risk of these adverse events.

AB - It would be desirable to be able to distinguish fever as a result of febrile non-haemolytic transfusion reactions (FNHTR) from other febrile conditions. To further characterize the inflammatory feature of FNHTR, we measured a large panel of inflammatory markers in pre- and posttransfusion plasma samples from patients with and without FNHTR following the transfusion of leucoreduced red blood cells. As FNHTR patients only displayed a significant increase in IL-6, we conclude that changes in plasma cytokine levels during FNHTR are unlikely to be used diagnostically. An incidental finding of a distinct cytokine pattern in pretransfusion samples from FNHTR patients warrants further investigations, as it might be used to characterize the nature of FNHTR and to predict the risk of these adverse events.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Biomarkers/blood

KW - Blood Transfusion

KW - Case-Control Studies

KW - Cytokines/blood

KW - Female

KW - Fever/blood

KW - Humans

KW - Male

KW - Middle Aged

KW - Transfusion Reaction/blood

KW - Young Adult

U2 - 10.1111/vox.12607

DO - 10.1111/vox.12607

M3 - Journal article

C2 - 29023768

VL - 113

SP - 76

EP - 79

JO - Vox Sanguinis

JF - Vox Sanguinis

SN - 0042-9007

IS - 1

ER -