Cervical cancer prevention among older women – challenges in screening, diagnostic workup and treatment

Line W. Gustafson*, Lone Kjeld Petersen, Pinar Bor, Berit Andersen, Anne Hammer

*Corresponding author for this work

Research output: Contribution to journalComment/debateResearchpeer-review

Abstract

Cervical cancer incidence and mortality have declined dramatically after screening for cervical cancer was implemented. Yet, studies have reported high cervical cancer incidence and mortality rates at older age despite low HPV prevalence and incidence of precursor lesions. The underlying reason for these findings remains unclear. However, it is well known that the impact of screening depends not only on the uptake and effectiveness of screening but also on the uptake and effectiveness of diagnostic workup (ie colposcopy), treatment and follow-up. In older women, sensitivity of screening and performance of colposcopy are impaired due to age-dependent changes to the cervix. In this commentary, we aimed to discuss challenges in screening and clinical management of older women, and to identify crucial areas of particular interest for future research.

Original languageEnglish
JournalActa Obstetricia et Gynecologica Scandinavica
Volume100
Issue number8
Pages (from-to)1364-1368
ISSN0001-6349
DOIs
Publication statusPublished - Aug 2021

Keywords

  • cervical cancer screening
  • cervical intraepithelial neoplasia
  • colposcopy
  • high-risk HPV
  • human papillomavirus
  • postmenopausal

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