Central venous catheters and bloodstream infection during induction therapy in children with acute lymphoblastic Leukemia

Kristin Bergmann, Henrik Hasle, Peter Asdahl, Mette Møller Handrup, Peder Skov Wehner , Steen Rosthøj, Henrik Schrøder

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The purpose of the study was to assess the risk of firsttime bloodstream infection (BSI) according to type of central venous catheter (CVC) during induction therapy in children with acute lymphoblastic leukemia (ALL). Patients eligible for our analysis were all newly diagnosed children with ALL treated at 3 pediatric centers in Denmark between 2008 and 2014. A total of 136 patients were followed from initial CVC placement until first BSI, CVC removal, death, or day 28, whichever occurred first. Thirty-nine BSIs were detected, of which 67% were gram-positive infections, and 59% met the criteria for being CVC associated. The 28-day cumulative incidence of BSI was similar in 77 patients with a nontunneled CVC (28%; 95% confidence interval, 19%-40%) and in 59 patients with a tunneled CVC with external lines (TE) (33%; 95% confidence interval, 23%-47%). Subgroup analyses showed that gram-negative blood isolates occurred more frequently in patients with a TE, and that lower incidences of BSI were detected in patients older than 9 years with a TE, and in patients with T-ALL. It is concluded that the type of CVC inserted at diagnosis has no impact upon the risk of BSI in patients with ALL undergoing induction therapy. © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Original languageEnglish
JournalJournal of Pediatric Hematology/Oncology
Volume38
Issue number3
Pages (from-to)e82-e87
ISSN1077-4114
DOIs
Publication statusPublished - 2016

Cite this

Bergmann, Kristin ; Hasle, Henrik ; Asdahl, Peter ; Handrup, Mette Møller ; Skov Wehner , Peder ; Rosthøj, Steen ; Schrøder, Henrik. / Central venous catheters and bloodstream infection during induction therapy in children with acute lymphoblastic Leukemia. In: Journal of Pediatric Hematology/Oncology. 2016 ; Vol. 38, No. 3. pp. e82-e87.
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abstract = "The purpose of the study was to assess the risk of firsttime bloodstream infection (BSI) according to type of central venous catheter (CVC) during induction therapy in children with acute lymphoblastic leukemia (ALL). Patients eligible for our analysis were all newly diagnosed children with ALL treated at 3 pediatric centers in Denmark between 2008 and 2014. A total of 136 patients were followed from initial CVC placement until first BSI, CVC removal, death, or day 28, whichever occurred first. Thirty-nine BSIs were detected, of which 67{\%} were gram-positive infections, and 59{\%} met the criteria for being CVC associated. The 28-day cumulative incidence of BSI was similar in 77 patients with a nontunneled CVC (28{\%}; 95{\%} confidence interval, 19{\%}-40{\%}) and in 59 patients with a tunneled CVC with external lines (TE) (33{\%}; 95{\%} confidence interval, 23{\%}-47{\%}). Subgroup analyses showed that gram-negative blood isolates occurred more frequently in patients with a TE, and that lower incidences of BSI were detected in patients older than 9 years with a TE, and in patients with T-ALL. It is concluded that the type of CVC inserted at diagnosis has no impact upon the risk of BSI in patients with ALL undergoing induction therapy. {\circledC} 2016 Wolters Kluwer Health, Inc. All rights reserved.",
author = "Kristin Bergmann and Henrik Hasle and Peter Asdahl and Handrup, {Mette M{\o}ller} and {Skov Wehner}, Peder and Steen Rosth{\o}j and Henrik Schr{\o}der",
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Central venous catheters and bloodstream infection during induction therapy in children with acute lymphoblastic Leukemia. / Bergmann, Kristin; Hasle, Henrik; Asdahl, Peter; Handrup, Mette Møller; Skov Wehner , Peder; Rosthøj, Steen; Schrøder, Henrik.

In: Journal of Pediatric Hematology/Oncology, Vol. 38, No. 3, 2016, p. e82-e87.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Central venous catheters and bloodstream infection during induction therapy in children with acute lymphoblastic Leukemia

AU - Bergmann, Kristin

AU - Hasle, Henrik

AU - Asdahl, Peter

AU - Handrup, Mette Møller

AU - Skov Wehner , Peder

AU - Rosthøj, Steen

AU - Schrøder, Henrik

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PY - 2016

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N2 - The purpose of the study was to assess the risk of firsttime bloodstream infection (BSI) according to type of central venous catheter (CVC) during induction therapy in children with acute lymphoblastic leukemia (ALL). Patients eligible for our analysis were all newly diagnosed children with ALL treated at 3 pediatric centers in Denmark between 2008 and 2014. A total of 136 patients were followed from initial CVC placement until first BSI, CVC removal, death, or day 28, whichever occurred first. Thirty-nine BSIs were detected, of which 67% were gram-positive infections, and 59% met the criteria for being CVC associated. The 28-day cumulative incidence of BSI was similar in 77 patients with a nontunneled CVC (28%; 95% confidence interval, 19%-40%) and in 59 patients with a tunneled CVC with external lines (TE) (33%; 95% confidence interval, 23%-47%). Subgroup analyses showed that gram-negative blood isolates occurred more frequently in patients with a TE, and that lower incidences of BSI were detected in patients older than 9 years with a TE, and in patients with T-ALL. It is concluded that the type of CVC inserted at diagnosis has no impact upon the risk of BSI in patients with ALL undergoing induction therapy. © 2016 Wolters Kluwer Health, Inc. All rights reserved.

AB - The purpose of the study was to assess the risk of firsttime bloodstream infection (BSI) according to type of central venous catheter (CVC) during induction therapy in children with acute lymphoblastic leukemia (ALL). Patients eligible for our analysis were all newly diagnosed children with ALL treated at 3 pediatric centers in Denmark between 2008 and 2014. A total of 136 patients were followed from initial CVC placement until first BSI, CVC removal, death, or day 28, whichever occurred first. Thirty-nine BSIs were detected, of which 67% were gram-positive infections, and 59% met the criteria for being CVC associated. The 28-day cumulative incidence of BSI was similar in 77 patients with a nontunneled CVC (28%; 95% confidence interval, 19%-40%) and in 59 patients with a tunneled CVC with external lines (TE) (33%; 95% confidence interval, 23%-47%). Subgroup analyses showed that gram-negative blood isolates occurred more frequently in patients with a TE, and that lower incidences of BSI were detected in patients older than 9 years with a TE, and in patients with T-ALL. It is concluded that the type of CVC inserted at diagnosis has no impact upon the risk of BSI in patients with ALL undergoing induction therapy. © 2016 Wolters Kluwer Health, Inc. All rights reserved.

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