Catalytic Staudinger Reduction at Room Temperature

Danny C. Lenstra, Joris J. Wolf, Jasmin Mecinović*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

497 Downloads (Pure)

Abstract

We report an efficient catalytic Staudinger reduction at room temperature that enables the preparation of a structurally diverse set of amines from azides in excellent yields. The reaction is based on the use of catalytic amounts of triphenylphosphine as a phosphine source and diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common functionalities, including nitriles, alkenes, alkynes, esters, and ketones.
Original languageEnglish
JournalThe Journal of Organic Chemistry
Volume84
Issue number10
Pages (from-to)6536-6545
ISSN0022-3263
DOIs
Publication statusPublished - 17. May 2019

Fingerprint

Dive into the research topics of 'Catalytic Staudinger Reduction at Room Temperature'. Together they form a unique fingerprint.

Cite this