Catalytic Staudinger Reduction at Room Temperature

Danny C. Lenstra, Joris J. Wolf, Jasmin Mecinović*

*Corresponding author for this work

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We report an efficient catalytic Staudinger reduction at room temperature that enables the preparation of a structurally diverse set of amines from azides in excellent yields. The reaction is based on the use of catalytic amounts of triphenylphosphine as a phosphine source and diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common functionalities, including nitriles, alkenes, alkynes, esters, and ketones.
Original languageEnglish
JournalThe Journal of Organic Chemistry
Issue number10
Pages (from-to)6536-6545
Publication statusPublished - 17. May 2019


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