Cardiorespiratory Fitness and Adiposity as Determinants of Metabolic Health-Pooled Analysis of Two Twin Cohorts

Sakari Jukarainen, René Holst, Christine Dalgård, Päivi Piirilä, Jesper Lundbom, Antti Hakkarainen, Nina Lundbom, Aila Rissanen, Jaakko Kaprio, Kirsten Ohm Kyvik, Thorkild I A Sørensen, Kirsi H Pietiläinen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Context: The joint effects of cardiorespiratory fitness (CRF) and body composition on metabolic health are not well known. Objective: To examine the associations of CRF, fat-free mass index (FFMI), and fatmass index (FMI) with metabolic health in individual twins and controlling for genetic and shared environmental effects by studying monozygotic intrapair differences. Design, Setting, and Participants: Two cross-sectional samples of healthy adult monozygotic and dizygotic twins were drawn from population-based Danish and Finnish national twin registries (n = 996 and n = 309). Main Measures: CRFwas defined asVO2max divided by fat-freemass. Insulin sensitivity and acute insulin response indices were derived from an oral glucose tolerance test. A continuous metabolic syndrome score was calculated. Visceral and liver fat were measured in the Finnish sample. Associations were analyzed separately in both cohorts with multivariate linear regression and aggregated with metaanalytic methods. Results: Insulin sensitivity, acute insulin response, metabolic syndrome score, visceral, and liver fat amount had strong and statistically significant associations with FMI (|β| 0.53 to 0.79), whereas their associations with CRF and FFMI were at most weak (|β| 0.02 to 0.15). The results of the monozygotic intrapair differences analysis showed the same pattern.

Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume102
Issue number5
Pages (from-to)1520-1528
ISSN0021-972X
DOIs
Publication statusPublished - 1. May 2017

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Adiposity
Intra-Abdominal Fat
Fats
Health
Insulin Resistance
Insulin
Dizygotic Twins
Monozygotic Twins
Liver
Glucose Tolerance Test
Registries
Linear Models
Linear regression
Environmental impact
Population
Cardiorespiratory Fitness
Glucose
Chemical analysis

Keywords

  • Journal Article

Cite this

Jukarainen, Sakari ; Holst, René ; Dalgård, Christine ; Piirilä, Päivi ; Lundbom, Jesper ; Hakkarainen, Antti ; Lundbom, Nina ; Rissanen, Aila ; Kaprio, Jaakko ; Kyvik, Kirsten Ohm ; Sørensen, Thorkild I A ; Pietiläinen, Kirsi H. / Cardiorespiratory Fitness and Adiposity as Determinants of Metabolic Health-Pooled Analysis of Two Twin Cohorts. In: Journal of Clinical Endocrinology and Metabolism. 2017 ; Vol. 102, No. 5. pp. 1520-1528.
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abstract = "Context: The joint effects of cardiorespiratory fitness (CRF) and body composition on metabolic health are not well known. Objective: To examine the associations of CRF, fat-free mass index (FFMI), and fatmass index (FMI) with metabolic health in individual twins and controlling for genetic and shared environmental effects by studying monozygotic intrapair differences. Design, Setting, and Participants: Two cross-sectional samples of healthy adult monozygotic and dizygotic twins were drawn from population-based Danish and Finnish national twin registries (n = 996 and n = 309). Main Measures: CRFwas defined asVO2max divided by fat-freemass. Insulin sensitivity and acute insulin response indices were derived from an oral glucose tolerance test. A continuous metabolic syndrome score was calculated. Visceral and liver fat were measured in the Finnish sample. Associations were analyzed separately in both cohorts with multivariate linear regression and aggregated with metaanalytic methods. Results: Insulin sensitivity, acute insulin response, metabolic syndrome score, visceral, and liver fat amount had strong and statistically significant associations with FMI (|β| 0.53 to 0.79), whereas their associations with CRF and FFMI were at most weak (|β| 0.02 to 0.15). The results of the monozygotic intrapair differences analysis showed the same pattern.",
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Jukarainen, S, Holst, R, Dalgård, C, Piirilä, P, Lundbom, J, Hakkarainen, A, Lundbom, N, Rissanen, A, Kaprio, J, Kyvik, KO, Sørensen, TIA & Pietiläinen, KH 2017, 'Cardiorespiratory Fitness and Adiposity as Determinants of Metabolic Health-Pooled Analysis of Two Twin Cohorts', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 5, pp. 1520-1528. https://doi.org/10.1210/jc.2016-3435

Cardiorespiratory Fitness and Adiposity as Determinants of Metabolic Health-Pooled Analysis of Two Twin Cohorts. / Jukarainen, Sakari; Holst, René; Dalgård, Christine; Piirilä, Päivi; Lundbom, Jesper; Hakkarainen, Antti; Lundbom, Nina; Rissanen, Aila; Kaprio, Jaakko; Kyvik, Kirsten Ohm; Sørensen, Thorkild I A; Pietiläinen, Kirsi H.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 102, No. 5, 01.05.2017, p. 1520-1528.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Cardiorespiratory Fitness and Adiposity as Determinants of Metabolic Health-Pooled Analysis of Two Twin Cohorts

AU - Jukarainen, Sakari

AU - Holst, René

AU - Dalgård, Christine

AU - Piirilä, Päivi

AU - Lundbom, Jesper

AU - Hakkarainen, Antti

AU - Lundbom, Nina

AU - Rissanen, Aila

AU - Kaprio, Jaakko

AU - Kyvik, Kirsten Ohm

AU - Sørensen, Thorkild I A

AU - Pietiläinen, Kirsi H

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Context: The joint effects of cardiorespiratory fitness (CRF) and body composition on metabolic health are not well known. Objective: To examine the associations of CRF, fat-free mass index (FFMI), and fatmass index (FMI) with metabolic health in individual twins and controlling for genetic and shared environmental effects by studying monozygotic intrapair differences. Design, Setting, and Participants: Two cross-sectional samples of healthy adult monozygotic and dizygotic twins were drawn from population-based Danish and Finnish national twin registries (n = 996 and n = 309). Main Measures: CRFwas defined asVO2max divided by fat-freemass. Insulin sensitivity and acute insulin response indices were derived from an oral glucose tolerance test. A continuous metabolic syndrome score was calculated. Visceral and liver fat were measured in the Finnish sample. Associations were analyzed separately in both cohorts with multivariate linear regression and aggregated with metaanalytic methods. Results: Insulin sensitivity, acute insulin response, metabolic syndrome score, visceral, and liver fat amount had strong and statistically significant associations with FMI (|β| 0.53 to 0.79), whereas their associations with CRF and FFMI were at most weak (|β| 0.02 to 0.15). The results of the monozygotic intrapair differences analysis showed the same pattern.

AB - Context: The joint effects of cardiorespiratory fitness (CRF) and body composition on metabolic health are not well known. Objective: To examine the associations of CRF, fat-free mass index (FFMI), and fatmass index (FMI) with metabolic health in individual twins and controlling for genetic and shared environmental effects by studying monozygotic intrapair differences. Design, Setting, and Participants: Two cross-sectional samples of healthy adult monozygotic and dizygotic twins were drawn from population-based Danish and Finnish national twin registries (n = 996 and n = 309). Main Measures: CRFwas defined asVO2max divided by fat-freemass. Insulin sensitivity and acute insulin response indices were derived from an oral glucose tolerance test. A continuous metabolic syndrome score was calculated. Visceral and liver fat were measured in the Finnish sample. Associations were analyzed separately in both cohorts with multivariate linear regression and aggregated with metaanalytic methods. Results: Insulin sensitivity, acute insulin response, metabolic syndrome score, visceral, and liver fat amount had strong and statistically significant associations with FMI (|β| 0.53 to 0.79), whereas their associations with CRF and FFMI were at most weak (|β| 0.02 to 0.15). The results of the monozygotic intrapair differences analysis showed the same pattern.

KW - Journal Article

U2 - 10.1210/jc.2016-3435

DO - 10.1210/jc.2016-3435

M3 - Journal article

C2 - 28324016

VL - 102

SP - 1520

EP - 1528

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 5

ER -