Abstract
Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) is a serious complication seen in approximately 20-30% of cardiac surgery patients. The underlying pathophysiology is complex, often involving both patient- and procedure related risk factors. In contrast to AKI occurring after other types of major surgery, the use of cardiopulmonary bypass comprises both additional advantages and challenges, including non-pulsatile flow, targeted blood flow and pressure as well as the ability to manipulate central venous pressure (congestion). With an increasing focus on the impact of CSA-AKI on both short and long-term mortality, early identification and management of high-risk patients for CSA-AKI has evolved. The present narrative review gives an up-to-date summary on definition, diagnosis, underlying pathophysiology, monitoring and implications of CSA-AKI, including potential preventive interventions. The review will provide the reader with an in-depth understanding of how to identify, support and provide a more personalized and tailored perioperative management to avoid development of CSA-AKI.
Original language | English |
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Journal | Perfusion |
Volume | 39 |
Issue number | 8 |
Pages (from-to) | 1516-1530 |
ISSN | 0267-6591 |
DOIs | |
Publication status | Published - Nov 2024 |
Keywords
- Acute kidney injury
- cardiac surgery
- cardiac surgery-associated acute kidney injury
- cardiopulmonary bypass
- renal replacement therapy
- Cardiopulmonary Bypass/adverse effects
- Humans
- Risk Factors
- Cardiac Surgical Procedures/adverse effects
- Acute Kidney Injury/etiology