Cardiac surgery-Associated acute kidney injury - A narrative review

Sebastian Buhl Rasmussen, Yuliya Boyko, Marco Ranucci, Filip de Somer, Hanne Berg Ravn*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) is a serious complication seen in approximately 20-30% of cardiac surgery patients. The underlying pathophysiology is complex, often involving both patient- and procedure related risk factors. In contrast to AKI occurring after other types of major surgery, the use of cardiopulmonary bypass comprises both additional advantages and challenges, including non-pulsatile flow, targeted blood flow and pressure as well as the ability to manipulate central venous pressure (congestion). With an increasing focus on the impact of CSA-AKI on both short and long-term mortality, early identification and management of high-risk patients for CSA-AKI has evolved. The present narrative review gives an up-to-date summary on definition, diagnosis, underlying pathophysiology, monitoring and implications of CSA-AKI, including potential preventive interventions. The review will provide the reader with an in-depth understanding of how to identify, support and provide a more personalized and tailored perioperative management to avoid development of CSA-AKI.

Original languageEnglish
JournalPerfusion
Volume39
Issue number8
Pages (from-to)1516-1530
ISSN0267-6591
DOIs
Publication statusPublished - Nov 2024

Keywords

  • Acute kidney injury
  • cardiac surgery
  • cardiac surgery-associated acute kidney injury
  • cardiopulmonary bypass
  • renal replacement therapy
  • Cardiopulmonary Bypass/adverse effects
  • Humans
  • Risk Factors
  • Cardiac Surgical Procedures/adverse effects
  • Acute Kidney Injury/etiology

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