Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles

Refaat B. Hamed, Jasmin Mecinović, Christian Ducho, T. D W Claridge, Christopher J. Schofield

Research output: Contribution to journalJournal articleResearchpeer-review


The utility of wild-type and variant carboxymethylproline synthases for biocatalysis was demonstrated by preparing functionalised 5-, 6- and 7-membered N-heterocycles from amino acid aldehydes and (alkylated) malonyl-coenzyme A derivatives; the N-heterocycles produced were converted to the corresponding bicyclic β-lactams by a carbapenem synthetase.

Original languageEnglish
JournalChemical Communications
Issue number9
Pages (from-to)1413-1415
Number of pages3
Publication statusPublished - 24. Feb 2010
Externally publishedYes


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