Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2´-O-methylations in 16S and 23S rRNAs

Shanna Køltzen Johansen, Courtney E. Maus, Bonnie B. Plikaytis, Stephen Roger Douthwaite

Research output: Contribution to journalJournal articleResearchpeer-review

Original languageEnglish
JournalMolecular Cell
Volume23
Pages (from-to)173-182
ISSN1097-2765
DOIs
Publication statusPublished - 21. Jul 2006

Keywords

  • Antibiotics, Antitubercular/pharmacology
  • Bacterial Proteins/genetics
  • Base Sequence
  • Capreomycin/pharmacology
  • Cloning, Molecular
  • Drug Resistance, Bacterial/genetics
  • Escherichia coli/drug effects
  • Mass Spectrometry
  • Methylation
  • Molecular Sequence Data
  • Mutation
  • Mycobacteriaceae/drug effects
  • Nucleic Acid Conformation
  • RNA, Bacterial/drug effects
  • RNA, Ribosomal, 16S/genetics
  • RNA, Ribosomal, 28S/genetics
  • Recombinant Proteins/genetics
  • Ribosomes/genetics

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