Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells

R Chen; A B Alvero; D-A Silasi; K D Steffensen; G Mor

doi:10.1038/sj.onc.1210907

Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells

R Chen
, A B Alvero
, D-A Silasi
, K D Steffensen
, G Mor

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression.

Original language	English
Journal	Oncogene
Volume	27
Issue number	2
Pages (from-to)	225-233
Number of pages	8
ISSN	0950-9232
DOIs	https://doi.org/10.1038/sj.onc.1210907
Publication status	Published - 7. Jan 2008

Keywords

Disease Progression
Drug Resistance, Neoplasm
Epigenesis, Genetic
Female
Gene Expression Regulation, Neoplastic
Humans
Inflammation
MicroRNAs
Models, Biological
Myeloid Differentiation Factor 88
NF-kappa B
Neoplasms
Neutrophil Infiltration
Ovarian Neoplasms
Signal Transduction
Toll-Like Receptor 4
Toll-Like Receptors

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10.1038/sj.onc.1210907

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Yale University
Dahl Steffensen, K. (Visiting researcher)
15. May 2007 → 1. Oct 2007
Activity: Visiting another research institution

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title = "Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells",

abstract = "Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression.",

keywords = "Disease Progression, Drug Resistance, Neoplasm, Epigenesis, Genetic, Female, Gene Expression Regulation, Neoplastic, Humans, Inflammation, MicroRNAs, Models, Biological, Myeloid Differentiation Factor 88, NF-kappa B, Neoplasms, Neutrophil Infiltration, Ovarian Neoplasms, Signal Transduction, Toll-Like Receptor 4, Toll-Like Receptors",

author = "R Chen and Alvero, \{A B\} and D-A Silasi and Steffensen, \{K D\} and G Mor",

year = "2008",

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doi = "10.1038/sj.onc.1210907",

language = "English",

volume = "27",

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TY - JOUR

T1 - Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells

AU - Chen, R

AU - Alvero, A B

AU - Silasi, D-A

AU - Steffensen, K D

AU - Mor, G

PY - 2008/1/7

Y1 - 2008/1/7

N2 - Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression.

AB - Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression.

KW - Disease Progression

KW - Drug Resistance, Neoplasm

KW - Epigenesis, Genetic

KW - Female

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Inflammation

KW - MicroRNAs

KW - Models, Biological

KW - Myeloid Differentiation Factor 88

KW - NF-kappa B

KW - Neoplasms

KW - Neutrophil Infiltration

KW - Ovarian Neoplasms

KW - Signal Transduction

KW - Toll-Like Receptor 4

KW - Toll-Like Receptors

U2 - 10.1038/sj.onc.1210907

DO - 10.1038/sj.onc.1210907

M3 - Journal article

C2 - 18176604

SN - 0950-9232

VL - 27

SP - 225

EP - 233

JO - Oncogene

JF - Oncogene

IS - 2

ER -

Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells

Abstract

Keywords

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