Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells

R Chen, A B Alvero, D-A Silasi, K D Steffensen, G Mor

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression.
Original languageEnglish
JournalOncogene
Volume27
Issue number2
Pages (from-to)225-233
Number of pages8
ISSN0950-9232
DOIs
Publication statusPublished - 7. Jan 2008

Fingerprint

Neoplasms
Ligands
Growth

Keywords

  • Disease Progression
  • Drug Resistance, Neoplasm
  • Epigenesis, Genetic
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Inflammation
  • MicroRNAs
  • Models, Biological
  • Myeloid Differentiation Factor 88
  • NF-kappa B
  • Neoplasms
  • Neutrophil Infiltration
  • Ovarian Neoplasms
  • Signal Transduction
  • Toll-Like Receptor 4
  • Toll-Like Receptors

Cite this

Chen, R ; Alvero, A B ; Silasi, D-A ; Steffensen, K D ; Mor, G. / Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells. In: Oncogene. 2008 ; Vol. 27, No. 2. pp. 225-233.
@article{68e90700441f11dd9fbe000ea68e967b,
title = "Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells",
abstract = "Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression.",
keywords = "Disease Progression, Drug Resistance, Neoplasm, Epigenesis, Genetic, Female, Gene Expression Regulation, Neoplastic, Humans, Inflammation, MicroRNAs, Models, Biological, Myeloid Differentiation Factor 88, NF-kappa B, Neoplasms, Neutrophil Infiltration, Ovarian Neoplasms, Signal Transduction, Toll-Like Receptor 4, Toll-Like Receptors",
author = "R Chen and Alvero, {A B} and D-A Silasi and Steffensen, {K D} and G Mor",
year = "2008",
month = "1",
day = "7",
doi = "10.1038/sj.onc.1210907",
language = "English",
volume = "27",
pages = "225--233",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",
number = "2",

}

Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells. / Chen, R; Alvero, A B; Silasi, D-A; Steffensen, K D; Mor, G.

In: Oncogene, Vol. 27, No. 2, 07.01.2008, p. 225-233.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells

AU - Chen, R

AU - Alvero, A B

AU - Silasi, D-A

AU - Steffensen, K D

AU - Mor, G

PY - 2008/1/7

Y1 - 2008/1/7

N2 - Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression.

AB - Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression.

KW - Disease Progression

KW - Drug Resistance, Neoplasm

KW - Epigenesis, Genetic

KW - Female

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Inflammation

KW - MicroRNAs

KW - Models, Biological

KW - Myeloid Differentiation Factor 88

KW - NF-kappa B

KW - Neoplasms

KW - Neutrophil Infiltration

KW - Ovarian Neoplasms

KW - Signal Transduction

KW - Toll-Like Receptor 4

KW - Toll-Like Receptors

U2 - 10.1038/sj.onc.1210907

DO - 10.1038/sj.onc.1210907

M3 - Journal article

VL - 27

SP - 225

EP - 233

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 2

ER -