Cancer and Longevity--Is There a Trade-off? A Study of Cooccurrence in Danish Twin Pairs Born 1900-1918

Kaare Christensen, Jacob K Pedersen, Jacob V B Hjelmborg, James W Vaupel, Tinna V. Stevnsner, Niels V Holm, Axel Skytthe

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, vice versa, that longevity potential comes with the cost of increased cancer risk. This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin.
Original languageEnglish
JournalThe Journals of Gerontology Series A
Volume67
Issue number5
Pages (from-to)489-494
ISSN1758-535X
DOIs
Publication statusPublished - 2012

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