Cancer and Longevity--Is There a Trade-off?: A Study of Cooccurrence in Danish Twin Pairs Born 1900-1918

Kaare Christensen; Jacob K Pedersen; Jacob V B Hjelmborg; James W Vaupel; Tinna V. Stevnsner; Niels V Holm; Axel Skytthe

doi:10.1093/gerona/gls087

Cancer and Longevity--Is There a Trade-off? A Study of Cooccurrence in Danish Twin Pairs Born 1900-1918

Kaare Christensen, Jacob K Pedersen, Jacob V B Hjelmborg, James W Vaupel, Tinna V. Stevnsner, Niels V Holm, Axel Skytthe

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, vice versa, that longevity potential comes with the cost of increased cancer risk. This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin.

Original language	English
Journal	The Journals of Gerontology Series A
Volume	67
Issue number	5
Pages (from-to)	489-494
ISSN	1758-535X
DOIs	https://doi.org/10.1093/gerona/gls087
Publication status	Published - 2012

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1 Finished

NorTwinCan - Nordisk Tvillingstudie af Cancer
Kaprio, J. (PI), Harris, J. R. (Co-PI), Jylhävä, J. (Co-PI), Hjelmborg, J. V. B. (Co-PI), Adami, H.-O. (CoI), Czene, K. (CoI), Mucci, L. A. (CoI) & Skytthe, A. (CoI)
01/01/2000 → 09/01/2024
Project: Research

Cite this

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title = "Cancer and Longevity--Is There a Trade-off?: A Study of Cooccurrence in Danish Twin Pairs Born 1900-1918",

abstract = "Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, vice versa, that longevity potential comes with the cost of increased cancer risk. This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin.",

author = "Kaare Christensen and Pedersen, {Jacob K} and Hjelmborg, {Jacob V B} and Vaupel, {James W} and Stevnsner, {Tinna V.} and Holm, {Niels V} and Axel Skytthe",

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T1 - Cancer and Longevity--Is There a Trade-off?

T2 - A Study of Cooccurrence in Danish Twin Pairs Born 1900-1918

AU - Christensen, Kaare

AU - Pedersen, Jacob K

AU - Hjelmborg, Jacob V B

AU - Vaupel, James W

AU - Stevnsner, Tinna V.

AU - Holm, Niels V

AU - Skytthe, Axel

PY - 2012

Y1 - 2012

N2 - Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, vice versa, that longevity potential comes with the cost of increased cancer risk. This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin.

AB - Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, vice versa, that longevity potential comes with the cost of increased cancer risk. This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin.

U2 - 10.1093/gerona/gls087

DO - 10.1093/gerona/gls087

M3 - Journal article

C2 - 22472962

SN - 1758-535X

VL - 67

SP - 489

EP - 494

JO - The Journals of Gerontology Series A

JF - The Journals of Gerontology Series A

IS - 5

ER -

Cancer and Longevity--Is There a Trade-off? A Study of Cooccurrence in Danish Twin Pairs Born 1900-1918

Abstract

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NorTwinCan - Nordisk Tvillingstudie af Cancer

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