Cancer and Longevity--Is There a Trade-off?

A Study of Cooccurrence in Danish Twin Pairs Born 1900-1918

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Abstract

Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, vice versa, that longevity potential comes with the cost of increased cancer risk. This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin.
Original languageEnglish
JournalJournals of Gerontology. Series A: Biological Sciences & Medical Sciences
Volume67
Issue number5
Pages (from-to)489-494
ISSN1079-5006
DOIs
Publication statusPublished - 2012

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title = "Cancer and Longevity--Is There a Trade-off?: A Study of Cooccurrence in Danish Twin Pairs Born 1900-1918",
abstract = "Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, vice versa, that longevity potential comes with the cost of increased cancer risk. This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin.",
author = "Kaare Christensen and Pedersen, {Jacob K} and Hjelmborg, {Jacob V B} and Vaupel, {James W} and Stevnsner, {Tinna V.} and Holm, {Niels V} and Axel Skytthe",
year = "2012",
doi = "10.1093/gerona/gls087",
language = "English",
volume = "67",
pages = "489--494",
journal = "Journals of Gerontology. Series A: Biological Sciences & Medical Sciences",
issn = "1079-5006",
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T1 - Cancer and Longevity--Is There a Trade-off?

T2 - A Study of Cooccurrence in Danish Twin Pairs Born 1900-1918

AU - Christensen, Kaare

AU - Pedersen, Jacob K

AU - Hjelmborg, Jacob V B

AU - Vaupel, James W

AU - Stevnsner, Tinna V.

AU - Holm, Niels V

AU - Skytthe, Axel

PY - 2012

Y1 - 2012

N2 - Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, vice versa, that longevity potential comes with the cost of increased cancer risk. This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin.

AB - Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, vice versa, that longevity potential comes with the cost of increased cancer risk. This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin.

U2 - 10.1093/gerona/gls087

DO - 10.1093/gerona/gls087

M3 - Journal article

VL - 67

SP - 489

EP - 494

JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences

SN - 1079-5006

IS - 5

ER -