Cancellous and Cortical Bone Microarchitectures of Femoral Neck in Rheumatoid Arthritis and Osteoarthritis Compared with Donor Controls

Bailiang Wang, Søren Overgaard, John Chemnitz, Ming Ding

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

This study investigated the 3D microarchitecture of cancellous and cortical bones of the femoral neck in rheumatoid arthritis (RA), osteoarthritis (OA) and donor controls. 26 femoral necks (including heads) were harvested during total hip replacement surgeries in 11 patients with RA (mean age 66.7 ± 12.8 years) and 15 patients with OA (67.3 ± 8.4 years). Femoral heads/necks were also harvested from 8 donors (74.9 ± 10.2 years). Bone samples of 10 mm thickness were prepared from each femoral neck and scanned with micro-CT to evaluate microarchitectural parameters. The RA and OA samples showed no significant differences in microarchitectural parameters in cancellous or cortical bone. Compared with the donor controls, bone volume fraction in RA and OA cancellous bone was significantly greater, the structure model index in OA was significantly lower, and the surface density in RA was significantly greater. The RA bone tissues showed erosion and marked osteophyte formation. This study demonstrated that RA and OA have similar trends of overall microarchitectural degeneration in the femoral neck, despite marked erosion in RA bone and osteophyte formation in OA bone. However, we could not eliminate the possibility of local differences between RA and OA bone. The age-related bone loss in RA and OA was less severe than those of normal ageing and osteoporosis, suggesting a compensatory effect of the diseases to increase bone density.

Original languageEnglish
JournalCalcified Tissue International
Volume98
Issue number5
Pages (from-to)456–464
ISSN0171-967X
DOIs
Publication statusPublished - May 2016

Keywords

  • 3D microarchitecture
  • Cancellous/cortical bones
  • Femoral neck
  • Osteoarthritis
  • Rheumatoid arthritis
  • Femur Neck/pathology
  • Cancellous Bone/pathology
  • Humans
  • Middle Aged
  • Male
  • Osteoarthritis, Hip/pathology
  • Arthritis, Rheumatoid/pathology
  • X-Ray Microtomography
  • Cortical Bone/pathology
  • Image Processing, Computer-Assisted
  • Female
  • Aged
  • Imaging, Three-Dimensional

Fingerprint

Dive into the research topics of 'Cancellous and Cortical Bone Microarchitectures of Femoral Neck in Rheumatoid Arthritis and Osteoarthritis Compared with Donor Controls'. Together they form a unique fingerprint.

Cite this