Calprotectin - A Marker of Mortality in COPD? Results from a Prospective Cohort Study

Dennis Back Holmgaard, Lone H Mygind, Ingrid Titlestad, Hanne Madsen, Svend Stenvang Pedersen, Ole Mortensen, Court Pedersen

Research output: Contribution to journalJournal articleResearchpeer-review


Calprotectin comprises more than 45% of the cytosolic content of neutrophil granulocytes. Because pathogenesis, disease activity and disease progression in COPD are believed to be partly dependent of neutrophil driven inflammation we decided to investigate whether plasma level of calprotectin (p-calprotectin) was associated with all-cause mortality in patients with COPD. We measured p-calprotectin in blood samples from 460 patients with moderate to very severe COPD in stable phase. Patients were stratified into three groups according to p-calprotectin level. Outcome measure was all-cause mortality. Analyses were adjusted for factors known to influence mortality using a Cox regression analysis. We found a time dependent correlation between p-calprotectin levels and mortality during the first 5 years of follow-up. Increasing levels of p-calprotectin were associated with concomitant increases in mortality from HR 1.56 (CI 95%: 1.03-2.38) at calprotectin between 100-200 ng/ml to HR 2.02 (CI 95%: 1.27-3.19) at calprotectin >200 ng/ml. P-calprotectin could be a useful marker of all-cause mortality in patients suffering from moderate to very severe COPD.

Original languageEnglish
JournalRespiratory Medicine: C O P D Update
Issue number5
Pages (from-to)581-587
Publication statusPublished - Oct 2013


  • Biomarker
  • Inflammation
  • Mortality
  • Neutrophil granulocytes
  • Severity of Illness Index
  • Multivariate Analysis
  • Pulmonary Disease, Chronic Obstructive/blood
  • Prognosis
  • Prospective Studies
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Kaplan-Meier Estimate
  • Proportional Hazards Models
  • Male
  • Neutrophils/immunology
  • Leukocyte L1 Antigen Complex/blood
  • Biomarkers/blood
  • Female
  • Aged
  • Cohort Studies


Dive into the research topics of 'Calprotectin - A Marker of Mortality in COPD? Results from a Prospective Cohort Study'. Together they form a unique fingerprint.

Cite this