Breast cancer onset in twins and women with bilateral disease

Mikael Hartman, Per Hall, Gustaf Edgren, Marie Reilly, Linda Lindstrom, Paul Lichtenstein, Jaakko Kaprio, Axel Skytthe, Julian Peto, Kamila Czene

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

PURPOSE: Little is known of the onset of breast cancer in high-risk populations. We investigated the risk of breast cancer in twin sisters and in the contralateral breast taking family history into consideration. PATIENTS AND METHODS: We analyzed a Scandinavian population-based cohort of 2,499 female twin pairs, in which at least one had a diagnosis of breast cancer and estimated the risk of breast cancer in the sister. Using a total of 11 million individuals in Sweden with complete family links, we identified 93,448 women with breast cancer and estimated the risk of a bilateral breast cancer. RESULTS: The incidence of breast cancer in twin sisters of breast cancer patients was 0.64% per year and 0.42% per year in mono- and dizygotic twin sisters, respectively. In comparison, the risk of familial (affected first-degree relative) and nonfamilial bilateral breast cancer was 1.03% per year and 0.68% per year, respectively. Contrary to the risk of unilateral disease, the risk of cancer in the nonaffected twin and the opposite breast was not affected by age or time since first event. The relative risk of familial bilateral cancer was 52% higher (incidence rate ratio [IRR] = 1.52; 95% CI, 1.42 to 1.64) and the relative risk in the dizygotic twin sister was 25% lower (IRR = 0.75; 95% CI, 0.61 to 0.91) compared with the risk of nonfamilial bilateral cancer. CONCLUSION: The elevated risk of breast cancer in high-risk groups is little affected by age and time since diagnosis. Our findings suggest that susceptible groups of women might have already aggregated genetic prerequisites for breast cancer.
Original languageEnglish
JournalJournal of Clinical Oncology
Volume26
Issue number25
Pages (from-to)4086-4091
Number of pages5
ISSN0732-183X
DOIs
Publication statusPublished - 1. Sep 2008

Fingerprint

Siblings
Dizygotic Twins
Incidence
Neoplasms
Monozygotic Twins
Population

Keywords

  • Breast Neoplasms
  • Cohort Studies
  • Denmark
  • Diseases in Twins
  • Family Health
  • Female
  • Finland
  • Genetic Predisposition to Disease
  • Humans
  • Incidence
  • Odds Ratio
  • Risk
  • Sweden
  • Time Factors
  • Treatment Outcome

Cite this

Hartman, M., Hall, P., Edgren, G., Reilly, M., Lindstrom, L., Lichtenstein, P., ... Czene, K. (2008). Breast cancer onset in twins and women with bilateral disease. Journal of Clinical Oncology, 26(25), 4086-4091. https://doi.org/10.1200/JCO.2007.14.3198
Hartman, Mikael ; Hall, Per ; Edgren, Gustaf ; Reilly, Marie ; Lindstrom, Linda ; Lichtenstein, Paul ; Kaprio, Jaakko ; Skytthe, Axel ; Peto, Julian ; Czene, Kamila. / Breast cancer onset in twins and women with bilateral disease. In: Journal of Clinical Oncology. 2008 ; Vol. 26, No. 25. pp. 4086-4091.
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abstract = "PURPOSE: Little is known of the onset of breast cancer in high-risk populations. We investigated the risk of breast cancer in twin sisters and in the contralateral breast taking family history into consideration. PATIENTS AND METHODS: We analyzed a Scandinavian population-based cohort of 2,499 female twin pairs, in which at least one had a diagnosis of breast cancer and estimated the risk of breast cancer in the sister. Using a total of 11 million individuals in Sweden with complete family links, we identified 93,448 women with breast cancer and estimated the risk of a bilateral breast cancer. RESULTS: The incidence of breast cancer in twin sisters of breast cancer patients was 0.64{\%} per year and 0.42{\%} per year in mono- and dizygotic twin sisters, respectively. In comparison, the risk of familial (affected first-degree relative) and nonfamilial bilateral breast cancer was 1.03{\%} per year and 0.68{\%} per year, respectively. Contrary to the risk of unilateral disease, the risk of cancer in the nonaffected twin and the opposite breast was not affected by age or time since first event. The relative risk of familial bilateral cancer was 52{\%} higher (incidence rate ratio [IRR] = 1.52; 95{\%} CI, 1.42 to 1.64) and the relative risk in the dizygotic twin sister was 25{\%} lower (IRR = 0.75; 95{\%} CI, 0.61 to 0.91) compared with the risk of nonfamilial bilateral cancer. CONCLUSION: The elevated risk of breast cancer in high-risk groups is little affected by age and time since diagnosis. Our findings suggest that susceptible groups of women might have already aggregated genetic prerequisites for breast cancer.",
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Hartman, M, Hall, P, Edgren, G, Reilly, M, Lindstrom, L, Lichtenstein, P, Kaprio, J, Skytthe, A, Peto, J & Czene, K 2008, 'Breast cancer onset in twins and women with bilateral disease', Journal of Clinical Oncology, vol. 26, no. 25, pp. 4086-4091. https://doi.org/10.1200/JCO.2007.14.3198

Breast cancer onset in twins and women with bilateral disease. / Hartman, Mikael; Hall, Per; Edgren, Gustaf; Reilly, Marie; Lindstrom, Linda; Lichtenstein, Paul; Kaprio, Jaakko; Skytthe, Axel; Peto, Julian; Czene, Kamila.

In: Journal of Clinical Oncology, Vol. 26, No. 25, 01.09.2008, p. 4086-4091.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Breast cancer onset in twins and women with bilateral disease

AU - Hartman, Mikael

AU - Hall, Per

AU - Edgren, Gustaf

AU - Reilly, Marie

AU - Lindstrom, Linda

AU - Lichtenstein, Paul

AU - Kaprio, Jaakko

AU - Skytthe, Axel

AU - Peto, Julian

AU - Czene, Kamila

PY - 2008/9/1

Y1 - 2008/9/1

N2 - PURPOSE: Little is known of the onset of breast cancer in high-risk populations. We investigated the risk of breast cancer in twin sisters and in the contralateral breast taking family history into consideration. PATIENTS AND METHODS: We analyzed a Scandinavian population-based cohort of 2,499 female twin pairs, in which at least one had a diagnosis of breast cancer and estimated the risk of breast cancer in the sister. Using a total of 11 million individuals in Sweden with complete family links, we identified 93,448 women with breast cancer and estimated the risk of a bilateral breast cancer. RESULTS: The incidence of breast cancer in twin sisters of breast cancer patients was 0.64% per year and 0.42% per year in mono- and dizygotic twin sisters, respectively. In comparison, the risk of familial (affected first-degree relative) and nonfamilial bilateral breast cancer was 1.03% per year and 0.68% per year, respectively. Contrary to the risk of unilateral disease, the risk of cancer in the nonaffected twin and the opposite breast was not affected by age or time since first event. The relative risk of familial bilateral cancer was 52% higher (incidence rate ratio [IRR] = 1.52; 95% CI, 1.42 to 1.64) and the relative risk in the dizygotic twin sister was 25% lower (IRR = 0.75; 95% CI, 0.61 to 0.91) compared with the risk of nonfamilial bilateral cancer. CONCLUSION: The elevated risk of breast cancer in high-risk groups is little affected by age and time since diagnosis. Our findings suggest that susceptible groups of women might have already aggregated genetic prerequisites for breast cancer.

AB - PURPOSE: Little is known of the onset of breast cancer in high-risk populations. We investigated the risk of breast cancer in twin sisters and in the contralateral breast taking family history into consideration. PATIENTS AND METHODS: We analyzed a Scandinavian population-based cohort of 2,499 female twin pairs, in which at least one had a diagnosis of breast cancer and estimated the risk of breast cancer in the sister. Using a total of 11 million individuals in Sweden with complete family links, we identified 93,448 women with breast cancer and estimated the risk of a bilateral breast cancer. RESULTS: The incidence of breast cancer in twin sisters of breast cancer patients was 0.64% per year and 0.42% per year in mono- and dizygotic twin sisters, respectively. In comparison, the risk of familial (affected first-degree relative) and nonfamilial bilateral breast cancer was 1.03% per year and 0.68% per year, respectively. Contrary to the risk of unilateral disease, the risk of cancer in the nonaffected twin and the opposite breast was not affected by age or time since first event. The relative risk of familial bilateral cancer was 52% higher (incidence rate ratio [IRR] = 1.52; 95% CI, 1.42 to 1.64) and the relative risk in the dizygotic twin sister was 25% lower (IRR = 0.75; 95% CI, 0.61 to 0.91) compared with the risk of nonfamilial bilateral cancer. CONCLUSION: The elevated risk of breast cancer in high-risk groups is little affected by age and time since diagnosis. Our findings suggest that susceptible groups of women might have already aggregated genetic prerequisites for breast cancer.

KW - Breast Neoplasms

KW - Cohort Studies

KW - Denmark

KW - Diseases in Twins

KW - Family Health

KW - Female

KW - Finland

KW - Genetic Predisposition to Disease

KW - Humans

KW - Incidence

KW - Odds Ratio

KW - Risk

KW - Sweden

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1200/JCO.2007.14.3198

DO - 10.1200/JCO.2007.14.3198

M3 - Journal article

VL - 26

SP - 4086

EP - 4091

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 25

ER -

Hartman M, Hall P, Edgren G, Reilly M, Lindstrom L, Lichtenstein P et al. Breast cancer onset in twins and women with bilateral disease. Journal of Clinical Oncology. 2008 Sep 1;26(25):4086-4091. https://doi.org/10.1200/JCO.2007.14.3198