Bone pain in multiple myeloma (Bpmm)—a protocol for a prospective, longitudinal, observational study

Marta Diaz-Delcastillo*, Rebecca E. Andrews, Aritri Mandal, Thomas L. Andersen, Andrew D. Chantry, Anne Marie Heegaard

*Corresponding author for this work

Research output: Contribution to journalJournal articleCommunication

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Multiple myeloma (MM) is a bone marrow neoplasia that causes bone pain in 70% patients. While preclinical models of MM have suggested that both nerve sprouting and nerve injury may be causative for the pain, there is a lack of clinical data. Thus, the primary aims of this clinical study are: (1) to provide a deep characterization of the subjective experience of pain and quality of life in MM patients; (2) to investigate disturbances in the bone innervation of MM patients. Secondary aims include exploring correlations between pain and serum inflammatory and bone turnover biomarkers. In a prospective, observational study ( NCT04273425), patients with suspected MM requiring a diagnostic iliac crest biopsy at Sheffield Teaching Hospital (UK) are invited to participate. Consenting patients answer seven standardized questionnaires assessing pain, quality of life and catastrophizing. Bone turnover biomarkers and inflammatory cytokines are measured in fasting serum samples, and bone innervation is evaluated in diagnostic biopsies. MM patients are invited to a follow-up upon completion of first line treatment. This will be the first deep characterization of pain in MM patients and its correlation with disturbances in bone innervation. Understanding how bone turnover and inflammation correlate to pain in MM is crucial to identify novel analgesic targets for this condition.

Original languageEnglish
Article number1596
Issue number7
Number of pages13
Publication statusPublished - 1. Apr 2021

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© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Bone cancer
  • Bone innervation
  • Multiple myeloma
  • Pain
  • Quality of life


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