Abstract
In this cross-sectional study of 45 patients with myeloproliferative neoplasms, we found no evidence of secondary osteoporosis.
INTRODUCTION: Patients with essential thrombocythemia (ET) and polycythaemia vera (PV) are at increased risk of fractures but the underlying mechanisms have not been settled. We conducted a study to assess bone mineral density, microarchitecture, estimated bone strength and global bone turnover in 45 patients with ET or PV.
METHODS: Patients were evaluated in a cross-sectional study with dual energy X-ray absorptiometry (DXA) at the hip and spine; high-resolution peripheral quantitative computed tomography (HR-pQCT) at the distal radius and distal tibia; and biochemical markers of bone turnover including pro-collagen type 1 N-terminal pro-peptide, osteocalcin, C-terminal cross-linking telopeptide of type 1 collagen and bone-specific alkaline phosphatase. Also, 45 healthy comparisons, matched on age, height and weight with each patient were included as control subjects.
RESULTS: Patients and comparisons had almost identical BMDs: 0.96 (IQR: 0.85-1.07) g/cm(2) and 0.96 g/cm(2) (IQR: 0.86-1.05 g/cm(2)), respectively. As well all microarchitecture and estimated bone strength measures were highly similar in the two groups. Levels of bone turnover markers were within reference values in patients.
CONCLUSION: These results reveal no evidence of secondary osteoporosis among patients with ET or PV. The mechanism behind the increased fracture risk in ET or PV patients remains unknown.
Original language | English |
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Journal | Osteoporosis International |
Volume | 28 |
Issue number | 2 |
Pages (from-to) | 677-685 |
ISSN | 0937-941X |
DOIs | |
Publication status | Published - 1. Feb 2017 |
Keywords
- Bone mineral density
- Chronic myeloproliferative neoplasms
- Essential thrombocythemia
- Microarchitecture
- Polycythemia vera
- Absorptiometry, Photon/methods
- Cross-Sectional Studies
- Lumbar Vertebrae/diagnostic imaging
- Tomography, X-Ray Computed/methods
- Thrombocythemia, Essential/pathology
- Humans
- Middle Aged
- Bone Density/physiology
- Male
- Hip Joint/diagnostic imaging
- Case-Control Studies
- Young Adult
- Adult
- Female
- Aged
- Polycythemia Vera/pathology
- Bone Remodeling/physiology