TY - JOUR
T1 - Bone marrow adipose tissue
T2 - Role in bone remodeling and energy metabolism
AU - Tencerova, Michaela
AU - Ferencakova, Michaela
AU - Kassem, Moustapha
N1 - Funding Information:
This work was supported by the Czech Science Foundation ( GACR 20-03586S ; PI: MT), EASD/NovoNordisk foundation Future leaders award ( NNF20SA0066174 ; PI:MT), Moustapha Kassem: NovoNordisk foundation (The NovoNordisk Foundation NNF ( 180C0054118 ).
PY - 2021/7
Y1 - 2021/7
N2 - Bone marrow adipose tissue (BMAT) has been considered for several decades as a silent bystander that fills empty space left in bone marrow following age-related decrease in hematopoiesis. However, recently new discoveries revealed BMAT as a secretory and metabolically active organ contributing to bone and whole-body energy metabolism. BMAT exhibits metabolic functions distinct from extramedullary adipose depots, relevant to its role in regulation of energy metabolism and its contribution to fracture risk observed in metabolic bone diseases. This review discusses novel insights of BMAT with particular emphasis on its contribution to the regulation of bone homeostasis. We also discuss the role of BMAT in regulation of fuel utilization and energy use that affect skeletal stem cell functions.
AB - Bone marrow adipose tissue (BMAT) has been considered for several decades as a silent bystander that fills empty space left in bone marrow following age-related decrease in hematopoiesis. However, recently new discoveries revealed BMAT as a secretory and metabolically active organ contributing to bone and whole-body energy metabolism. BMAT exhibits metabolic functions distinct from extramedullary adipose depots, relevant to its role in regulation of energy metabolism and its contribution to fracture risk observed in metabolic bone diseases. This review discusses novel insights of BMAT with particular emphasis on its contribution to the regulation of bone homeostasis. We also discuss the role of BMAT in regulation of fuel utilization and energy use that affect skeletal stem cell functions.
KW - bone marrow adipose tissue
KW - bone marrow mesenchymal stem cells
KW - energy metabolism
KW - metabolic pathways
U2 - 10.1016/j.beem.2021.101545
DO - 10.1016/j.beem.2021.101545
M3 - Journal article
C2 - 33966979
AN - SCOPUS:85107042727
SN - 1521-690X
VL - 35
JO - Best Practice & Research Clinical Endocrinology & Metabolism
JF - Best Practice & Research Clinical Endocrinology & Metabolism
IS - 4
M1 - 101545
ER -