Abstract
Osteogenesis imperfecta (OI) is a hereditary disorder characterized by decreased biosynthesis or impaired morphology of type I collagen that leads to decreased bone mass and increased bone fragility. We hypothesized that patients with OI have altered bone microstructure and bone geometry. In this cross-sectional study we compared patients with type I OI to age- and gender-matched healthy controls. A total of 39 (13 men and 26 women) patients with OI, aged 53 (range, 21-77) years, and 39 controls, aged 53 (range, 21-77) years, were included in the study. Twenty-seven of the patients had been treated with bisphosphonates. High-resolution peripheral quantitative computed tomography (HR-pQCT) at the distal radius and distal tibia and dual-energy X-ray absorptiometry of total hip, femoral neck, trochanteric region, and the lumbar spine (L1-L4) were performed. The patients were shorter than the controls (159 ± 10 cm versus 170 ± 9 cm, p
Original language | English |
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Journal | Journal of Bone and Mineral Research |
Volume | 27 |
Issue number | 6 |
Pages (from-to) | 1405-12 |
Number of pages | 8 |
ISSN | 0884-0431 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- Adult
- Aged
- Area Under Curve
- Bone Density
- Cohort Studies
- Female
- Humans
- Male
- Middle Aged
- Models, Biological
- Osteogenesis Imperfecta
- Radius
- Spinal Fractures
- Tibia
- Tibial Fractures
- Tomography, X-Ray Computed
- Young Adult