Bone geometry, density, and microarchitecture in the distal radius and tibia in adults with osteogenesis imperfecta type I assessed by high-resolution pQCT

Lars Folkestad, Jannie Dahl Hald, Stinus Hansen, Jeppe Gram, Bente Lomholt Langdahl, Bo Abrahamsen, Kim Brixen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Osteogenesis imperfecta (OI) is a hereditary disorder characterized by decreased biosynthesis or impaired morphology of type I collagen that leads to decreased bone mass and increased bone fragility. We hypothesized that patients with OI have altered bone microstructure and bone geometry. In this cross-sectional study we compared patients with type I OI to age- and gender-matched healthy controls. A total of 39 (13 men and 26 women) patients with OI, aged 53 (range, 21-77) years, and 39 controls, aged 53 (range, 21-77) years, were included in the study. Twenty-seven of the patients had been treated with bisphosphonates. High-resolution peripheral quantitative computed tomography (HR-pQCT) at the distal radius and distal tibia and dual-energy X-ray absorptiometry of total hip, femoral neck, trochanteric region, and the lumbar spine (L1-L4) were performed. The patients were shorter than the controls (159 ± 10 cm versus 170 ± 9 cm, p 
Original languageEnglish
JournalJournal of Bone and Mineral Research
Volume27
Issue number6
Pages (from-to)1405-12
Number of pages8
ISSN0884-0431
DOIs
Publication statusPublished - 2012

Keywords

  • Adult
  • Aged
  • Area Under Curve
  • Bone Density
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Models, Biological
  • Osteogenesis Imperfecta
  • Radius
  • Spinal Fractures
  • Tibia
  • Tibial Fractures
  • Tomography, X-Ray Computed
  • Young Adult

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