Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

Jack Feehan; Moustapha Kassem; Robert J. Pignolo; Gustavo Duque

doi:10.1002/jbmr.4204

Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

Jack Feehan, Moustapha Kassem, Robert J. Pignolo, Gustavo Duque^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases. © 2020 American Society for Bone and Mineral Research (ASBMR).

Original language	English
Journal	Journal of Bone and Mineral Research
Volume	36
Issue number	1
Pages (from-to)	12-23
ISSN	0884-0431
DOIs	https://doi.org/10.1002/jbmr.4204
Publication status	Published - Jan 2021

Keywords

CIRCULATING OSTEOGENIC PRECURSOR CELLS
COP CELLS
FRACTURE
FRAILTY
HETEROTOPIC OSSIFICATION
OSTEOPOROSIS
VASCULAR CALCIFICATION

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10.1002/jbmr.4204

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title = "Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells",

abstract = "Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases. {\textcopyright} 2020 American Society for Bone and Mineral Research (ASBMR).",

keywords = "CIRCULATING OSTEOGENIC PRECURSOR CELLS, COP CELLS, FRACTURE, FRAILTY, HETEROTOPIC OSSIFICATION, OSTEOPOROSIS, VASCULAR CALCIFICATION",

author = "Jack Feehan and Moustapha Kassem and Pignolo, {Robert J.} and Gustavo Duque",

year = "2021",

month = jan,

doi = "10.1002/jbmr.4204",

language = "English",

volume = "36",

pages = "12--23",

journal = "Journal of Bone and Mineral Research",

issn = "0884-0431",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Bone From Blood

T2 - Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

AU - Feehan, Jack

AU - Kassem, Moustapha

AU - Pignolo, Robert J.

AU - Duque, Gustavo

PY - 2021/1

Y1 - 2021/1

N2 - Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases. © 2020 American Society for Bone and Mineral Research (ASBMR).

AB - Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases. © 2020 American Society for Bone and Mineral Research (ASBMR).

KW - CIRCULATING OSTEOGENIC PRECURSOR CELLS

KW - COP CELLS

KW - FRACTURE

KW - FRAILTY

KW - HETEROTOPIC OSSIFICATION

KW - OSTEOPOROSIS

KW - VASCULAR CALCIFICATION

U2 - 10.1002/jbmr.4204

DO - 10.1002/jbmr.4204

M3 - Journal article

C2 - 33118647

AN - SCOPUS:85096761725

SN - 0884-0431

VL - 36

SP - 12

EP - 23

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 1

ER -

Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

Abstract

Keywords

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