Body composition and menstrual status in adults with a history of anorexia nervosa: At what fat percentage is the menstrual cycle restored?

Laura Al-Dakhiel Winkler, Jacob Stampe Frølich, Maya Schulpen, René Klinkby Støving

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: To study the association between body composition measures and menstrual status in a large sample of adult patients with a history of anorexia nervosa and to calculate the predicted probability of resumption of menstrual function. Furthermore, to establish whether fat percentage is superior to body mass index in predicting the resumption of menses.

METHOD: One hundred and thirteen adult women with a history of anorexia nervosa underwent a dual energy X-ray absorptiometry (DXA) scan and completed questionnaires regarding medication prescription and menstrual function.

RESULTS: Fifty percent of patients were expected to resume their menstrual function at a body mass index of 19 kg m(-2) or a fat percentage of 23%. Twenty-five percent of patients were expected to resume their menstrual function at body mass index 14 kg m(-2) or fat percentage 11%. Fat percentage and body mass index were equally capable of predicting the resumption of menses.

DISCUSSION: Fat percentage and body mass index were positive predictors of the resumption of menses, however, body composition measured by dual energy X-ray absorptiometry was not superior to body mass index in predicting menstrual recovery, which is of great clinical relevance as body mass index is easier and cheaper to obtain. Body composition measures only account for one of numerous factors involved in the resumption of menses. Regression models based on our data had a R(2) value of 0.14, indicating that only 14% of the variation in menstrual recovery could be explained by the variables included. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016).

Original languageEnglish
JournalInternational Journal of Eating Disorders
Volume50
Issue number4
Pages (from-to)370–377
ISSN0276-3478
DOIs
Publication statusPublished - Apr 2017

Fingerprint

Body Mass Index
Fats
Menstruation
Photon Absorptiometry
Prescriptions

Keywords

  • amenorrhea
  • anorexia nervosa
  • body composition
  • dual energy X-ray absorptiometry
  • menstrual status
  • Body Mass Index
  • Humans
  • Absorptiometry, Photon
  • Young Adult
  • Body Composition/physiology
  • Menstruation/physiology
  • Adolescent
  • Adult
  • Female
  • Menstrual Cycle/physiology
  • Anorexia Nervosa/diagnostic imaging

Cite this

@article{8ec33fae1e9b486a989b70369b7c2da8,
title = "Body composition and menstrual status in adults with a history of anorexia nervosa: At what fat percentage is the menstrual cycle restored?",
abstract = "OBJECTIVE: To study the association between body composition measures and menstrual status in a large sample of adult patients with a history of anorexia nervosa and to calculate the predicted probability of resumption of menstrual function. Furthermore, to establish whether fat percentage is superior to body mass index in predicting the resumption of menses.METHOD: One hundred and thirteen adult women with a history of anorexia nervosa underwent a dual energy X-ray absorptiometry (DXA) scan and completed questionnaires regarding medication prescription and menstrual function.RESULTS: Fifty percent of patients were expected to resume their menstrual function at a body mass index of 19 kg m(-2) or a fat percentage of 23{\%}. Twenty-five percent of patients were expected to resume their menstrual function at body mass index 14 kg m(-2) or fat percentage 11{\%}. Fat percentage and body mass index were equally capable of predicting the resumption of menses.DISCUSSION: Fat percentage and body mass index were positive predictors of the resumption of menses, however, body composition measured by dual energy X-ray absorptiometry was not superior to body mass index in predicting menstrual recovery, which is of great clinical relevance as body mass index is easier and cheaper to obtain. Body composition measures only account for one of numerous factors involved in the resumption of menses. Regression models based on our data had a R(2) value of 0.14, indicating that only 14{\%} of the variation in menstrual recovery could be explained by the variables included. {\circledC} 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016).",
keywords = "amenorrhea, anorexia nervosa, body composition, dual energy X-ray absorptiometry, menstrual status, Body Mass Index, Humans, Absorptiometry, Photon, Young Adult, Body Composition/physiology, Menstruation/physiology, Adolescent, Adult, Female, Menstrual Cycle/physiology, Anorexia Nervosa/diagnostic imaging",
author = "Winkler, {Laura Al-Dakhiel} and Fr{\o}lich, {Jacob Stampe} and Maya Schulpen and St{\o}ving, {Ren{\'e} Klinkby}",
note = "{\circledC} 2016 Wiley Periodicals, Inc.",
year = "2017",
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doi = "10.1002/eat.22600",
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volume = "50",
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journal = "International Journal of Eating Disorders",
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Body composition and menstrual status in adults with a history of anorexia nervosa : At what fat percentage is the menstrual cycle restored? / Winkler, Laura Al-Dakhiel; Frølich, Jacob Stampe ; Schulpen, Maya; Støving, René Klinkby.

In: International Journal of Eating Disorders, Vol. 50, No. 4, 04.2017, p. 370–377.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Body composition and menstrual status in adults with a history of anorexia nervosa

T2 - At what fat percentage is the menstrual cycle restored?

AU - Winkler, Laura Al-Dakhiel

AU - Frølich, Jacob Stampe

AU - Schulpen, Maya

AU - Støving, René Klinkby

N1 - © 2016 Wiley Periodicals, Inc.

PY - 2017/4

Y1 - 2017/4

N2 - OBJECTIVE: To study the association between body composition measures and menstrual status in a large sample of adult patients with a history of anorexia nervosa and to calculate the predicted probability of resumption of menstrual function. Furthermore, to establish whether fat percentage is superior to body mass index in predicting the resumption of menses.METHOD: One hundred and thirteen adult women with a history of anorexia nervosa underwent a dual energy X-ray absorptiometry (DXA) scan and completed questionnaires regarding medication prescription and menstrual function.RESULTS: Fifty percent of patients were expected to resume their menstrual function at a body mass index of 19 kg m(-2) or a fat percentage of 23%. Twenty-five percent of patients were expected to resume their menstrual function at body mass index 14 kg m(-2) or fat percentage 11%. Fat percentage and body mass index were equally capable of predicting the resumption of menses.DISCUSSION: Fat percentage and body mass index were positive predictors of the resumption of menses, however, body composition measured by dual energy X-ray absorptiometry was not superior to body mass index in predicting menstrual recovery, which is of great clinical relevance as body mass index is easier and cheaper to obtain. Body composition measures only account for one of numerous factors involved in the resumption of menses. Regression models based on our data had a R(2) value of 0.14, indicating that only 14% of the variation in menstrual recovery could be explained by the variables included. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016).

AB - OBJECTIVE: To study the association between body composition measures and menstrual status in a large sample of adult patients with a history of anorexia nervosa and to calculate the predicted probability of resumption of menstrual function. Furthermore, to establish whether fat percentage is superior to body mass index in predicting the resumption of menses.METHOD: One hundred and thirteen adult women with a history of anorexia nervosa underwent a dual energy X-ray absorptiometry (DXA) scan and completed questionnaires regarding medication prescription and menstrual function.RESULTS: Fifty percent of patients were expected to resume their menstrual function at a body mass index of 19 kg m(-2) or a fat percentage of 23%. Twenty-five percent of patients were expected to resume their menstrual function at body mass index 14 kg m(-2) or fat percentage 11%. Fat percentage and body mass index were equally capable of predicting the resumption of menses.DISCUSSION: Fat percentage and body mass index were positive predictors of the resumption of menses, however, body composition measured by dual energy X-ray absorptiometry was not superior to body mass index in predicting menstrual recovery, which is of great clinical relevance as body mass index is easier and cheaper to obtain. Body composition measures only account for one of numerous factors involved in the resumption of menses. Regression models based on our data had a R(2) value of 0.14, indicating that only 14% of the variation in menstrual recovery could be explained by the variables included. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016).

KW - amenorrhea

KW - anorexia nervosa

KW - body composition

KW - dual energy X-ray absorptiometry

KW - menstrual status

KW - Body Mass Index

KW - Humans

KW - Absorptiometry, Photon

KW - Young Adult

KW - Body Composition/physiology

KW - Menstruation/physiology

KW - Adolescent

KW - Adult

KW - Female

KW - Menstrual Cycle/physiology

KW - Anorexia Nervosa/diagnostic imaging

U2 - 10.1002/eat.22600

DO - 10.1002/eat.22600

M3 - Journal article

C2 - 27570102

VL - 50

SP - 370

EP - 377

JO - International Journal of Eating Disorders

JF - International Journal of Eating Disorders

SN - 0276-3478

IS - 4

ER -