Blood pressure in 3-year-old girls associates inversely with umbilical cord serum 25-hydroxyvitamin D: an Odense Child Cohort study

Søs Dragsbæk Larsen*, Christine Dalgård, Mathilde Egelund Christensen, Sine Lykkedegn, Louise Bjørkholt Andersen, Marianne Andersen, Dorte Glintborg, Henrik Thybo Christesen

*Corresponding author for this work

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Abstract

Background: Low foetal vitamin D status may be associated with higher blood pressure (BP) in later life. Objective: To examine whether serum 25-hydroxyvitamin D 2+3 (s-25OHD) in cord and pregnancy associates with systolic and diastolic BP (SBP; DBP) in children up to 3 years of age. Design: Prospective, population-based cohort study. Methods: We included 1594 singletons from the Odense Child Cohort with available cord s-25OHD and BP data at median age 3.7 months (48% girls), 18.9 months (44% girls) or 3 years (48% girls). Maternal s-25OHD was also assessed at gestational ages 12 and 29 weeks. Multiple regression models were stratified by sex a priori and adjusted for maternal educational level, season of birth and child height, weight and age. Results: In 3-year-old girls, SBP decreased with −0.7 mmHg (95% CI −1.1; −0.3, P = 0.001) and DBP with −0.4 mmHg (95% CI −0.7; −0.1, P = 0.016) for every 10 nmol/L increase in cord s-25OHD in adjusted analyses. Moreover, the adjusted odds of having SBP >90th percentile were reduced by 30% for every 10 nmol/L increase in cord s-25OHD (P = 0.004) and by 64% for cord s-25OHD above the median 45.1 nmol/L (P = 0.02). Similar findings were observed between pregnancy s-25OHD and 3-year SBP, cord s-25OHD and SBP at 18.9 months, and cord s-25OHD and DBP at 3 years. No consistent associations were observed between s-25OHD and BP in boys. Conclusion: Cord s-25OHD was inversely associated with SBP and DBP in young girls, but not in boys. Higher vitamin D status in foetal life may modulate BP in young girls. The sex difference remains unexplained.

Original languageEnglish
JournalEndocrine Connections
Volume7
Issue number12
Pages (from-to)1236–1244
ISSN2049-3614
DOIs
Publication statusPublished - 1. Oct 2018

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Umbilical Cord
Cohort Studies
Serum
25-Hydroxyvitamin D 2
Mothers
Sex Characteristics
Gestational Age
25-hydroxyvitamin D
Weights and Measures
Population

Keywords

  • Blood pressure
  • Children
  • Sex-dimorphism
  • Vitamin D

Cite this

@article{acfc569664fd4f2ebca476a9687d365f,
title = "Blood pressure in 3-year-old girls associates inversely with umbilical cord serum 25-hydroxyvitamin D: an Odense Child Cohort study",
abstract = "Background: Low foetal vitamin D status may be associated with higher blood pressure (BP) in later life. Objective: To examine whether serum 25-hydroxyvitamin D 2+3 (s-25OHD) in cord and pregnancy associates with systolic and diastolic BP (SBP; DBP) in children up to 3 years of age. Design: Prospective, population-based cohort study. Methods: We included 1594 singletons from the Odense Child Cohort with available cord s-25OHD and BP data at median age 3.7 months (48{\%} girls), 18.9 months (44{\%} girls) or 3 years (48{\%} girls). Maternal s-25OHD was also assessed at gestational ages 12 and 29 weeks. Multiple regression models were stratified by sex a priori and adjusted for maternal educational level, season of birth and child height, weight and age. Results: In 3-year-old girls, SBP decreased with −0.7 mmHg (95{\%} CI −1.1; −0.3, P = 0.001) and DBP with −0.4 mmHg (95{\%} CI −0.7; −0.1, P = 0.016) for every 10 nmol/L increase in cord s-25OHD in adjusted analyses. Moreover, the adjusted odds of having SBP >90th percentile were reduced by 30{\%} for every 10 nmol/L increase in cord s-25OHD (P = 0.004) and by 64{\%} for cord s-25OHD above the median 45.1 nmol/L (P = 0.02). Similar findings were observed between pregnancy s-25OHD and 3-year SBP, cord s-25OHD and SBP at 18.9 months, and cord s-25OHD and DBP at 3 years. No consistent associations were observed between s-25OHD and BP in boys. Conclusion: Cord s-25OHD was inversely associated with SBP and DBP in young girls, but not in boys. Higher vitamin D status in foetal life may modulate BP in young girls. The sex difference remains unexplained.",
keywords = "Blood pressure, Children, Sex-dimorphism, Vitamin D",
author = "Larsen, {S{\o}s Dragsb{\ae}k} and Christine Dalg{\aa}rd and Christensen, {Mathilde Egelund} and Sine Lykkedegn and Andersen, {Louise Bj{\o}rkholt} and Marianne Andersen and Dorte Glintborg and Christesen, {Henrik Thybo}",
year = "2018",
month = "10",
day = "1",
doi = "10.1530/EC-18-0308",
language = "English",
volume = "7",
pages = "1236–1244",
journal = "Endocrine Connections",
issn = "2049-3614",
publisher = "BioScientifica Ltd.",
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}

Blood pressure in 3-year-old girls associates inversely with umbilical cord serum 25-hydroxyvitamin D : an Odense Child Cohort study. / Larsen, Søs Dragsbæk; Dalgård, Christine; Christensen, Mathilde Egelund; Lykkedegn, Sine; Andersen, Louise Bjørkholt; Andersen, Marianne; Glintborg, Dorte; Christesen, Henrik Thybo.

In: Endocrine Connections, Vol. 7, No. 12, 01.10.2018, p. 1236–1244.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Blood pressure in 3-year-old girls associates inversely with umbilical cord serum 25-hydroxyvitamin D

T2 - an Odense Child Cohort study

AU - Larsen, Søs Dragsbæk

AU - Dalgård, Christine

AU - Christensen, Mathilde Egelund

AU - Lykkedegn, Sine

AU - Andersen, Louise Bjørkholt

AU - Andersen, Marianne

AU - Glintborg, Dorte

AU - Christesen, Henrik Thybo

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background: Low foetal vitamin D status may be associated with higher blood pressure (BP) in later life. Objective: To examine whether serum 25-hydroxyvitamin D 2+3 (s-25OHD) in cord and pregnancy associates with systolic and diastolic BP (SBP; DBP) in children up to 3 years of age. Design: Prospective, population-based cohort study. Methods: We included 1594 singletons from the Odense Child Cohort with available cord s-25OHD and BP data at median age 3.7 months (48% girls), 18.9 months (44% girls) or 3 years (48% girls). Maternal s-25OHD was also assessed at gestational ages 12 and 29 weeks. Multiple regression models were stratified by sex a priori and adjusted for maternal educational level, season of birth and child height, weight and age. Results: In 3-year-old girls, SBP decreased with −0.7 mmHg (95% CI −1.1; −0.3, P = 0.001) and DBP with −0.4 mmHg (95% CI −0.7; −0.1, P = 0.016) for every 10 nmol/L increase in cord s-25OHD in adjusted analyses. Moreover, the adjusted odds of having SBP >90th percentile were reduced by 30% for every 10 nmol/L increase in cord s-25OHD (P = 0.004) and by 64% for cord s-25OHD above the median 45.1 nmol/L (P = 0.02). Similar findings were observed between pregnancy s-25OHD and 3-year SBP, cord s-25OHD and SBP at 18.9 months, and cord s-25OHD and DBP at 3 years. No consistent associations were observed between s-25OHD and BP in boys. Conclusion: Cord s-25OHD was inversely associated with SBP and DBP in young girls, but not in boys. Higher vitamin D status in foetal life may modulate BP in young girls. The sex difference remains unexplained.

AB - Background: Low foetal vitamin D status may be associated with higher blood pressure (BP) in later life. Objective: To examine whether serum 25-hydroxyvitamin D 2+3 (s-25OHD) in cord and pregnancy associates with systolic and diastolic BP (SBP; DBP) in children up to 3 years of age. Design: Prospective, population-based cohort study. Methods: We included 1594 singletons from the Odense Child Cohort with available cord s-25OHD and BP data at median age 3.7 months (48% girls), 18.9 months (44% girls) or 3 years (48% girls). Maternal s-25OHD was also assessed at gestational ages 12 and 29 weeks. Multiple regression models were stratified by sex a priori and adjusted for maternal educational level, season of birth and child height, weight and age. Results: In 3-year-old girls, SBP decreased with −0.7 mmHg (95% CI −1.1; −0.3, P = 0.001) and DBP with −0.4 mmHg (95% CI −0.7; −0.1, P = 0.016) for every 10 nmol/L increase in cord s-25OHD in adjusted analyses. Moreover, the adjusted odds of having SBP >90th percentile were reduced by 30% for every 10 nmol/L increase in cord s-25OHD (P = 0.004) and by 64% for cord s-25OHD above the median 45.1 nmol/L (P = 0.02). Similar findings were observed between pregnancy s-25OHD and 3-year SBP, cord s-25OHD and SBP at 18.9 months, and cord s-25OHD and DBP at 3 years. No consistent associations were observed between s-25OHD and BP in boys. Conclusion: Cord s-25OHD was inversely associated with SBP and DBP in young girls, but not in boys. Higher vitamin D status in foetal life may modulate BP in young girls. The sex difference remains unexplained.

KW - Blood pressure

KW - Children

KW - Sex-dimorphism

KW - Vitamin D

U2 - 10.1530/EC-18-0308

DO - 10.1530/EC-18-0308

M3 - Journal article

C2 - 30352408

VL - 7

SP - 1236

EP - 1244

JO - Endocrine Connections

JF - Endocrine Connections

SN - 2049-3614

IS - 12

ER -