Biomolecular Recognition of Methylated Histones

Miriam Porzberg, Bas J.G.E. Pieters, Jasmin Mecinovic

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

Lysine and arginine methylations are among the most abundant posttranslational modifications found on histone proteins. The recognition of methylated lysine and arginine residues by epigenetic reader proteins provides an important molecular requirement for regulation of human genes. Recent structural and mechanistic studies importantly advanced our basic understanding of biomolecular recognition of methylated histones by diverse classes of epigenetic readers. In this chapter, we describe chemical biological studies on the recognition of methylated histones by the aromatic cage-containing reader proteins.

Original languageEnglish
Title of host publicationThe DNA, RNA, and Histone Methylomes
Number of pages17
PublisherSpringer
Publication date29. Aug 2019
Pages435-451
ISBN (Print)978-3-030-14791-4
ISBN (Electronic)978-3-030-14792-1
DOIs
Publication statusPublished - 29. Aug 2019
SeriesRNA Technologies (RNATECHN)
ISSN2197-9758

Keywords

  • Biomolecular recognition
  • Epigenetics
  • Histone
  • Methylation
  • Reader proteins

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