Biomarkers of insulin action during single soccer sessions before and after a 12-week training period in type 2 diabetes patients on a caloric-restricted diet

Maysa V de Sousa, Rosa Fukui, Samuel Dagogo-Jack, Peter Krustrup, Hassane Zouhal, Maria Elizabeth R da Silva

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND: We investigated the biomarkers of insulin action as well as changes in free fatty acids and lactate concentration after an acute soccer session pre and post training with caloric-restricted diet versus diet alone in type 2 diabetes (T2D) patients.

METHODS: Fifty-one middle-aged (61.1 ± 6.4 years) T2D patients were randomly allocated to the soccer+diet group (SDG) or the diet group (DG). The control group comprised T2D patients observing a caloric-restricted diet who did not receive soccer training. Over 12 weeks, SDG performed 3 × 40 min per week of soccer training.

RESULTS: The first soccer session for SDG induced acute increases in blood lactate (1.4 ± 0.1-6.0 ± 0.7 mmol/L, P < 0.05) and glucagon levels (112.1 ± 6.2-142.9 ± 8.0 pg/mL, P < 0.05), whereas glucose and insulin levels remained unchanged. Moreover, this session showed suppressed insulin levels as well as higher free fatty acids, lactate levels and glucagon/insulin ratio compared to DG (p < 0.05). After 12 weeks, a baseline decrease was observed in glucagon, leptin and lactate levels in SDG and DG (p < 0.05), whereas HOMA-IR, Adipo-IR and glucose levels were lower only in SDG (p < 0.05). At the last soccer training session, the blood lactate response was significantly lower than for the first session (4.0 ± 0.4 vs 6.0 ± 0.7 mmol/L). At 48 h pre intervention, a decrease was observed in leptin levels (p < 0.05), which remained lower post intervention. The positive correlation between leptin and insulin, and the lower levels after training, could be attributed to the improved insulin sensitivity along with the weight loss observed in both groups (~3.4 kg for DG and 3.7 kg for SDG).

CONCLUSION: Acute soccer sessions markedly improved insulin action markers in T2D patients, while the cumulative effects enhanced insulin sensitivity and decreased risk factors associated with cardiovascular disease after 12 weeks of intervention better than caloric-restricted diet.

Original languageEnglish
Article number112618
JournalPhysiology & Behavior
Volume209
Number of pages10
ISSN0031-9384
DOIs
Publication statusPublished - 1. Oct 2019

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Soccer
Type 2 Diabetes Mellitus
Insulin
Diet
Lactic Acid
Leptin
Glucagon
Nonesterified Fatty Acids
Insulin Resistance

Keywords

  • Exercise
  • Free fatty acids
  • Glucagon
  • High-intensity training
  • Insulin sensitivity
  • Lactate

Cite this

@article{2cf3e1be32f24f109f0114b9055f5580,
title = "Biomarkers of insulin action during single soccer sessions before and after a 12-week training period in type 2 diabetes patients on a caloric-restricted diet",
abstract = "BACKGROUND: We investigated the biomarkers of insulin action as well as changes in free fatty acids and lactate concentration after an acute soccer session pre and post training with caloric-restricted diet versus diet alone in type 2 diabetes (T2D) patients.METHODS: Fifty-one middle-aged (61.1 ± 6.4 years) T2D patients were randomly allocated to the soccer+diet group (SDG) or the diet group (DG). The control group comprised T2D patients observing a caloric-restricted diet who did not receive soccer training. Over 12 weeks, SDG performed 3 × 40 min per week of soccer training.RESULTS: The first soccer session for SDG induced acute increases in blood lactate (1.4 ± 0.1-6.0 ± 0.7 mmol/L, P < 0.05) and glucagon levels (112.1 ± 6.2-142.9 ± 8.0 pg/mL, P < 0.05), whereas glucose and insulin levels remained unchanged. Moreover, this session showed suppressed insulin levels as well as higher free fatty acids, lactate levels and glucagon/insulin ratio compared to DG (p < 0.05). After 12 weeks, a baseline decrease was observed in glucagon, leptin and lactate levels in SDG and DG (p < 0.05), whereas HOMA-IR, Adipo-IR and glucose levels were lower only in SDG (p < 0.05). At the last soccer training session, the blood lactate response was significantly lower than for the first session (4.0 ± 0.4 vs 6.0 ± 0.7 mmol/L). At 48 h pre intervention, a decrease was observed in leptin levels (p < 0.05), which remained lower post intervention. The positive correlation between leptin and insulin, and the lower levels after training, could be attributed to the improved insulin sensitivity along with the weight loss observed in both groups (~3.4 kg for DG and 3.7 kg for SDG).CONCLUSION: Acute soccer sessions markedly improved insulin action markers in T2D patients, while the cumulative effects enhanced insulin sensitivity and decreased risk factors associated with cardiovascular disease after 12 weeks of intervention better than caloric-restricted diet.",
keywords = "Exercise, Free fatty acids, Glucagon, High-intensity training, Insulin sensitivity, Lactate",
author = "{de Sousa}, {Maysa V} and Rosa Fukui and Samuel Dagogo-Jack and Peter Krustrup and Hassane Zouhal and {da Silva}, {Maria Elizabeth R}",
note = "Copyright {\circledC} 2019. Published by Elsevier Inc.",
year = "2019",
month = "10",
day = "1",
doi = "10.1016/j.physbeh.2019.112618",
language = "English",
volume = "209",
journal = "Physiology & Behavior",
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}

Biomarkers of insulin action during single soccer sessions before and after a 12-week training period in type 2 diabetes patients on a caloric-restricted diet. / de Sousa, Maysa V; Fukui, Rosa; Dagogo-Jack, Samuel; Krustrup, Peter; Zouhal, Hassane; da Silva, Maria Elizabeth R.

In: Physiology & Behavior, Vol. 209, 112618, 01.10.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Biomarkers of insulin action during single soccer sessions before and after a 12-week training period in type 2 diabetes patients on a caloric-restricted diet

AU - de Sousa, Maysa V

AU - Fukui, Rosa

AU - Dagogo-Jack, Samuel

AU - Krustrup, Peter

AU - Zouhal, Hassane

AU - da Silva, Maria Elizabeth R

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - BACKGROUND: We investigated the biomarkers of insulin action as well as changes in free fatty acids and lactate concentration after an acute soccer session pre and post training with caloric-restricted diet versus diet alone in type 2 diabetes (T2D) patients.METHODS: Fifty-one middle-aged (61.1 ± 6.4 years) T2D patients were randomly allocated to the soccer+diet group (SDG) or the diet group (DG). The control group comprised T2D patients observing a caloric-restricted diet who did not receive soccer training. Over 12 weeks, SDG performed 3 × 40 min per week of soccer training.RESULTS: The first soccer session for SDG induced acute increases in blood lactate (1.4 ± 0.1-6.0 ± 0.7 mmol/L, P < 0.05) and glucagon levels (112.1 ± 6.2-142.9 ± 8.0 pg/mL, P < 0.05), whereas glucose and insulin levels remained unchanged. Moreover, this session showed suppressed insulin levels as well as higher free fatty acids, lactate levels and glucagon/insulin ratio compared to DG (p < 0.05). After 12 weeks, a baseline decrease was observed in glucagon, leptin and lactate levels in SDG and DG (p < 0.05), whereas HOMA-IR, Adipo-IR and glucose levels were lower only in SDG (p < 0.05). At the last soccer training session, the blood lactate response was significantly lower than for the first session (4.0 ± 0.4 vs 6.0 ± 0.7 mmol/L). At 48 h pre intervention, a decrease was observed in leptin levels (p < 0.05), which remained lower post intervention. The positive correlation between leptin and insulin, and the lower levels after training, could be attributed to the improved insulin sensitivity along with the weight loss observed in both groups (~3.4 kg for DG and 3.7 kg for SDG).CONCLUSION: Acute soccer sessions markedly improved insulin action markers in T2D patients, while the cumulative effects enhanced insulin sensitivity and decreased risk factors associated with cardiovascular disease after 12 weeks of intervention better than caloric-restricted diet.

AB - BACKGROUND: We investigated the biomarkers of insulin action as well as changes in free fatty acids and lactate concentration after an acute soccer session pre and post training with caloric-restricted diet versus diet alone in type 2 diabetes (T2D) patients.METHODS: Fifty-one middle-aged (61.1 ± 6.4 years) T2D patients were randomly allocated to the soccer+diet group (SDG) or the diet group (DG). The control group comprised T2D patients observing a caloric-restricted diet who did not receive soccer training. Over 12 weeks, SDG performed 3 × 40 min per week of soccer training.RESULTS: The first soccer session for SDG induced acute increases in blood lactate (1.4 ± 0.1-6.0 ± 0.7 mmol/L, P < 0.05) and glucagon levels (112.1 ± 6.2-142.9 ± 8.0 pg/mL, P < 0.05), whereas glucose and insulin levels remained unchanged. Moreover, this session showed suppressed insulin levels as well as higher free fatty acids, lactate levels and glucagon/insulin ratio compared to DG (p < 0.05). After 12 weeks, a baseline decrease was observed in glucagon, leptin and lactate levels in SDG and DG (p < 0.05), whereas HOMA-IR, Adipo-IR and glucose levels were lower only in SDG (p < 0.05). At the last soccer training session, the blood lactate response was significantly lower than for the first session (4.0 ± 0.4 vs 6.0 ± 0.7 mmol/L). At 48 h pre intervention, a decrease was observed in leptin levels (p < 0.05), which remained lower post intervention. The positive correlation between leptin and insulin, and the lower levels after training, could be attributed to the improved insulin sensitivity along with the weight loss observed in both groups (~3.4 kg for DG and 3.7 kg for SDG).CONCLUSION: Acute soccer sessions markedly improved insulin action markers in T2D patients, while the cumulative effects enhanced insulin sensitivity and decreased risk factors associated with cardiovascular disease after 12 weeks of intervention better than caloric-restricted diet.

KW - Exercise

KW - Free fatty acids

KW - Glucagon

KW - High-intensity training

KW - Insulin sensitivity

KW - Lactate

U2 - 10.1016/j.physbeh.2019.112618

DO - 10.1016/j.physbeh.2019.112618

M3 - Journal article

VL - 209

JO - Physiology & Behavior

JF - Physiology & Behavior

SN - 0031-9384

M1 - 112618

ER -