Biomarkers in patients with Chronic Obstructive Pulmonary Disease in general practice: A prospective cohort study

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Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a common chronic disease primarily treated in primary care. It is a complex and heterogeneous disease and the trajectory is difficult to predict. The overall aim of this study is to investigate predictors of the trajectory of COPD treated in primary care and to determine the added value of selected biomarkers such as microfibrillar-associated protein 4 (MFAP4) and surfactant protein D (SP-D).
Methods: Prospective cohort study comprising COPD patients. A total of 38 Danish practices were included in the study. Criteria for inclusion were a diagnosis of COPD (ICPC code R95-), age ≥ 40 years, Danish language speaking, no severe psychiatric or cognitive disease and ability to visit the GP surgery. Prevalent as well as incident patients diagnosed with COPD were eligible. Baseline data included a patient questionnaire and validated questionnaires regarding respiration, activity of daily living, depression and fatigue. Further, clinical indicators of the patient’s COPD status were obtained ad well as blood samples for biomarkers. End points will include rates of exacerbations, hospitalizations, deaths and decline in lung function.
Results: We included 634 patients of whom 52% are females. The mean age of the study population is 68.1 years. Additional baseline characteristics and preliminary results will be presented at the congress.
In this study we explore determinants of trajectory for COPD in primary care and the added value of selected biomarkers.
Original languageEnglish
Publication date2017
Number of pages1
Publication statusPublished - 2017
Event20th Nordic Congress of General Practice: From the core - Harpa - Concert Hall and Conference Centre, Reykjavik, Iceland
Duration: 14. Jun 201716. Jun 2017
Conference number: 20


Conference20th Nordic Congress of General Practice
LocationHarpa - Concert Hall and Conference Centre
Internet address

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