Biomarkers for the detection of prenatal alcohol exposure

a review

Heidi Bager, Lars Porskjær Christensen, Steffen Husby, Lene Berit Skov Bjerregaard

Research output: Contribution to journalReviewResearchpeer-review

Abstract

Alcohol exposure during pregnancy can cause adverse effects to the fetus, because it interferes with fetal development, leading to later physical and mental impairment. The most common clinical tool to determine fetal alcohol exposure is maternal self‐reporting. However, a more objective and useful method is based on the use of biomarkers in biological specimens alone or in combination with maternal self‐reporting. This review reports on clinically relevant biomarkers for detection of prenatal alcohol exposure (PAE). A systematic search was performed to ensure a proper overview in existing literature. Studies were selected to give an overview on clinically relevant neonatal and maternal biomarkers. The direct biomarkers fatty acid ethyl esters (FAEEs), ethyl glucuronide (EtG), ethyl sulfate, and phosphatidylethanol (PEth) were found to be the most appropriate biomarkers in relation to detection of PAE. To review each biomarker in a clinical context, we have compared the advantages and disadvantages of each biomarker, in relation to its window of detectability, ease of collection, and the ease and cost of analysis of each biomarker. The biomarkers PEth, FAEEs, and EtG were found to be applicable for detection of even low levels of alcohol exposure. Meconium is an accessible matrix for determination of FAEEs and EtG, and blood an accessible matrix for determination of PEth.
Original languageEnglish
JournalAlcoholism: Clinical and Experimental Research
Volume41
Issue number2
Pages (from-to)251-261
ISSN0145-6008
DOIs
Publication statusPublished - 2017

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Biomarkers
Alcohols
Esters
Fatty Acids
Mothers
Maternal Exposure
Meconium
Fetus
Blood

Cite this

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title = "Biomarkers for the detection of prenatal alcohol exposure: a review",
abstract = "Alcohol exposure during pregnancy can cause adverse effects to the fetus, because it interferes with fetal development, leading to later physical and mental impairment. The most common clinical tool to determine fetal alcohol exposure is maternal self‐reporting. However, a more objective and useful method is based on the use of biomarkers in biological specimens alone or in combination with maternal self‐reporting. This review reports on clinically relevant biomarkers for detection of prenatal alcohol exposure (PAE). A systematic search was performed to ensure a proper overview in existing literature. Studies were selected to give an overview on clinically relevant neonatal and maternal biomarkers. The direct biomarkers fatty acid ethyl esters (FAEEs), ethyl glucuronide (EtG), ethyl sulfate, and phosphatidylethanol (PEth) were found to be the most appropriate biomarkers in relation to detection of PAE. To review each biomarker in a clinical context, we have compared the advantages and disadvantages of each biomarker, in relation to its window of detectability, ease of collection, and the ease and cost of analysis of each biomarker. The biomarkers PEth, FAEEs, and EtG were found to be applicable for detection of even low levels of alcohol exposure. Meconium is an accessible matrix for determination of FAEEs and EtG, and blood an accessible matrix for determination of PEth.",
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Biomarkers for the detection of prenatal alcohol exposure : a review. / Bager, Heidi; Christensen, Lars Porskjær ; Husby, Steffen; Bjerregaard, Lene Berit Skov.

In: Alcoholism: Clinical and Experimental Research, Vol. 41, No. 2, 2017, p. 251-261.

Research output: Contribution to journalReviewResearchpeer-review

TY - JOUR

T1 - Biomarkers for the detection of prenatal alcohol exposure

T2 - a review

AU - Bager, Heidi

AU - Christensen, Lars Porskjær

AU - Husby, Steffen

AU - Bjerregaard, Lene Berit Skov

PY - 2017

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AB - Alcohol exposure during pregnancy can cause adverse effects to the fetus, because it interferes with fetal development, leading to later physical and mental impairment. The most common clinical tool to determine fetal alcohol exposure is maternal self‐reporting. However, a more objective and useful method is based on the use of biomarkers in biological specimens alone or in combination with maternal self‐reporting. This review reports on clinically relevant biomarkers for detection of prenatal alcohol exposure (PAE). A systematic search was performed to ensure a proper overview in existing literature. Studies were selected to give an overview on clinically relevant neonatal and maternal biomarkers. The direct biomarkers fatty acid ethyl esters (FAEEs), ethyl glucuronide (EtG), ethyl sulfate, and phosphatidylethanol (PEth) were found to be the most appropriate biomarkers in relation to detection of PAE. To review each biomarker in a clinical context, we have compared the advantages and disadvantages of each biomarker, in relation to its window of detectability, ease of collection, and the ease and cost of analysis of each biomarker. The biomarkers PEth, FAEEs, and EtG were found to be applicable for detection of even low levels of alcohol exposure. Meconium is an accessible matrix for determination of FAEEs and EtG, and blood an accessible matrix for determination of PEth.

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