Biomarker patterns in patients with cardiogenic shock versus septic shock

Elma J. Peters, Martin S. Frydland, Christian Hassager, Lieuwe D.J. Bos, Lonneke A. van Vught, Olaf L. Cremer, Jacob E. Møller, Bert Jan H. van den Born, Alexander P.J. Vlaar, Jose P.S. Henriques*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Background: In cardiogenic shock (CS), contractile failure is often accompanied by a systemic inflammatory response syndrome. In contrast, many patients with septic shock (SS) develop cardiac dysfunction. A similar hemodynamic support strategy is often deployed in both syndromes but it is unclear whether this is justified based on profiles of biomarkers expressing neurohormonal activation and cardiovascular stress. Methods: In this prospective, multicenter cohort, 111 patients with acute myocardial infarction related CS were identified, and matched to patients with SS. Clinical parameters were collected and blood samples were obtained on day 1–3 of Intensive Care admission. Results: In this shock cohort comprising 222 patients, with a mean age of 61 (±13.5) years and of whom 161 (37 %) were male, we found that despite obvious clinical disparities on admission, mortality at 30-days did not differ (CS: 40.5 % vs. SS 43.1 %, p = 0.56). Overall, plasma concentrations of all biomarkers were higher in SS patients, with the largest difference on the first day. However, only in CS patients the biomarker concentrations were associated with mortality. Conclusion: In this prospective, multicenter cohort SS and CS patients showed similarities in baseline conditions and had similar mortality. However, several biomarkers only showed prognostic value in CS.

Original languageEnglish
Article number101424
JournalIJC Heart & Vasculature
Volume52
ISSN2352-9067
DOIs
Publication statusPublished - Jun 2024

Keywords

  • Biomarkers
  • Cardiogenic shock
  • Mortality
  • Septic shock

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