Biological variability in aspartate aminotransferase activity in serum of healthy persons, and effect of in vitro supplementation with pyridoxal 5 phosphate

M. Horder, G. N. Bowers

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Aspartate aminotransferase (EC 2.6.1.1) activities in sera from nine healthy individuals were monitored during two weeks, both with and without first supplementing the serum with pyridoxal phosphate. Pyridoxal phosphate supplementation caused a mean increase of 39% (range, 33 55%) in measured activity. The biological variability during the two week period was independent of pyridoxal phosphate supplementation. The intra individual variability (CV) was 5.3% and 5.1% with and without pyridoxal phosphate supplementation, respectively; the corresponding interindividual variability was 13.2% and 13.6%. We conclude that the reference interval will be insensitive to intra individual fluctuations in aspartate aminotransferase activity in serum, whether or not the serum is supplemented with pyridoxal phosphate.

Original languageEnglish
JournalClinical Chemistry
Volume23
Issue number3
Pages (from-to)551-554
ISSN0009-9147
Publication statusPublished - 1. Jan 1977
Externally publishedYes

Fingerprint

Dive into the research topics of 'Biological variability in aspartate aminotransferase activity in serum of healthy persons, and effect of in vitro supplementation with pyridoxal 5 phosphate'. Together they form a unique fingerprint.

Cite this