Benchmark dose modelling in regulatory ecotoxicology, a potential tool in pest management

Signe M Jensen*, Felix M Kluxen, Christian Ritz

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

For several authorities, benchmark dose (BMD) methodology has become the recommended approach by which to derive reference values for risk assessment. However, in practice, the BMD approach is not standard use in risk assessment for pesticides where the no observed adverse effect level, lowest observed adverse effect level and effective dose (ED50 or EDx ) prevail. Regression-based BMD and the benchmark dose lower confidence limit (BMDL) have several advantages, such as utilizing more information from the generated data and being less dependent on tested dose levels. However, the BMD approach requires some degree of expert knowledge for defining an appropriate risk level for estimating the BMD and using more sophisticated statistical methods to calculate BMD and BMDL. The BMD approach is one way to move away from p value-based binary decision-making towards putting the weight on effect sizes. We review the advantages and disadvantages of focusing on the BMD approach for risk assessment of pesticides. Further, we discuss potential applications in efficacy trials for pest management purposes. © 2021 Society of Chemical Industry.

Original languageEnglish
JournalPest Management Science
Volume78
Issue number5
Pages (from-to)1772-1779
ISSN1526-498X
DOIs
Publication statusPublished - May 2022

Keywords

  • LOAEL
  • NOAEL
  • ecotoxicology
  • risk assessment
  • toxicology
  • Dose-Response Relationship, Drug
  • Pest Control
  • No-Observed-Adverse-Effect Level
  • Ecotoxicology
  • Pesticides/toxicity
  • Benchmarking
  • Risk Assessment/methods

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