Behandling af svær astma med biologiske lægemidler hos børn og unge

Translated title of the contribution: Biological drugs for treatment of children and adolescents with severe asthma

Katrine Bredsdorff Spangenberg, Uffe Bødtger, Kirsten Skamstrup Hansen, Bo Lund Krogsgaard Chawes

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Prerequisites for successful treatment of severe asthma in children and adolescents with biological drugs are: 1) systematic assessment, excluding and treating other causes of lack of asthma control, 2) immunological phenotyping of the patient, and 3) choice of biological drug targeting the specific disease mechanism. Anti-immunoglobulin (Ig) E and anti-interleukin (IL)-5 have a clinically relevant effect reducing exacerbation rate, but there is still a need for studies in children and adolescents being treated with anti-IgE and anti-IL-5 as well as newer biological drugs, which affect lung function, asthma control and quality of life.
Original languageDanish
Article numberV05180364
JournalUgeskrift for Laeger
Volume181
Issue number20
Pages (from-to)1876-1880
ISSN0041-5782
Publication statusPublished - 14. Oct 2019

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Interleukin-5
Pharmaceutical Preparations
Quality of Life
Lung

Keywords

  • Severe asthma
  • Treatment

Cite this

Spangenberg, K. B., Bødtger, U., Hansen, K. S., & Chawes, B. L. K. (2019). Behandling af svær astma med biologiske lægemidler hos børn og unge. Ugeskrift for Laeger, 181(20), 1876-1880. [V05180364].
Spangenberg, Katrine Bredsdorff ; Bødtger, Uffe ; Hansen, Kirsten Skamstrup ; Chawes, Bo Lund Krogsgaard. / Behandling af svær astma med biologiske lægemidler hos børn og unge. In: Ugeskrift for Laeger. 2019 ; Vol. 181, No. 20. pp. 1876-1880.
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abstract = "Prerequisites for successful treatment of severe asthma in children and adolescents with biological drugs are: 1) systematic assessment, excluding and treating other causes of lack of asthma control, 2) immunological phenotyping of the patient, and 3) choice of biological drug targeting the specific disease mechanism. Anti-immunoglobulin (Ig) E and anti-interleukin (IL)-5 have a clinically relevant effect reducing exacerbation rate, but there is still a need for studies in children and adolescents being treated with anti-IgE and anti-IL-5 as well as newer biological drugs, which affect lung function, asthma control and quality of life.",
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Spangenberg, KB, Bødtger, U, Hansen, KS & Chawes, BLK 2019, 'Behandling af svær astma med biologiske lægemidler hos børn og unge', Ugeskrift for Laeger, vol. 181, no. 20, V05180364, pp. 1876-1880.

Behandling af svær astma med biologiske lægemidler hos børn og unge. / Spangenberg, Katrine Bredsdorff; Bødtger, Uffe; Hansen, Kirsten Skamstrup; Chawes, Bo Lund Krogsgaard.

In: Ugeskrift for Laeger, Vol. 181, No. 20, V05180364, 14.10.2019, p. 1876-1880.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Behandling af svær astma med biologiske lægemidler hos børn og unge

AU - Spangenberg, Katrine Bredsdorff

AU - Bødtger, Uffe

AU - Hansen, Kirsten Skamstrup

AU - Chawes, Bo Lund Krogsgaard

PY - 2019/10/14

Y1 - 2019/10/14

N2 - Prerequisites for successful treatment of severe asthma in children and adolescents with biological drugs are: 1) systematic assessment, excluding and treating other causes of lack of asthma control, 2) immunological phenotyping of the patient, and 3) choice of biological drug targeting the specific disease mechanism. Anti-immunoglobulin (Ig) E and anti-interleukin (IL)-5 have a clinically relevant effect reducing exacerbation rate, but there is still a need for studies in children and adolescents being treated with anti-IgE and anti-IL-5 as well as newer biological drugs, which affect lung function, asthma control and quality of life.

AB - Prerequisites for successful treatment of severe asthma in children and adolescents with biological drugs are: 1) systematic assessment, excluding and treating other causes of lack of asthma control, 2) immunological phenotyping of the patient, and 3) choice of biological drug targeting the specific disease mechanism. Anti-immunoglobulin (Ig) E and anti-interleukin (IL)-5 have a clinically relevant effect reducing exacerbation rate, but there is still a need for studies in children and adolescents being treated with anti-IgE and anti-IL-5 as well as newer biological drugs, which affect lung function, asthma control and quality of life.

KW - Severe asthma

KW - Treatment

M3 - Tidsskriftartikel

VL - 181

SP - 1876

EP - 1880

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

SN - 0041-5782

IS - 20

M1 - V05180364

ER -

Spangenberg KB, Bødtger U, Hansen KS, Chawes BLK. Behandling af svær astma med biologiske lægemidler hos børn og unge. Ugeskrift for Laeger. 2019 Oct 14;181(20):1876-1880. V05180364.