Autologous Fat Grafting as Treatment for Chronic Pain

Research output: ThesisPh.D. thesis

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Abstract

This Ph.D. thesis is based on research performed at the Department of Plastic Surgery, Odense University hospital, from 2017-2020. All funding was covered by the department in addition to a grant from the Region of Southern Denmark.


We performed three clinical studies with the purpose of investigating the possible effect of autologous fat grafting (AFG) on two distinct neuropathic pain syndromes: postherpetic neuralgia (PHN) and post-mastectomy pain syndrome (PMPS).


Studies I and II investigated the possible pain-relieving effect of AFG on patients suffering from PHN. Study III investigated the effect of AFG on patients suffering from PMPS. Study I was designed as an unblinded, feasibility trial where we performed
AFG on ten patients. Study II and III were designed as double-blinded randomized clinical trials (RCT) where treatment of AFG was compared to a placebo, sham procedure.


In all studies, the primary outcome measures were the average- and maximum degree of pain measured using a numerical rating scale. The secondary outcome was the quality and degree of neuropathic pain and Quality of Life. Neuropathic pain was measured using the Neuropathic Pain Symptom Inventory. Quality of Life was measured using the Short Form-36.


The results of Study I indicated AFG to significantly improve pain from PHN. However when compared to a sham/placebo in our RCT, AFG was not superior. This was also the case of our RCT on AGF as treatment of PMPS. Based on our results, we cannot recommend the routine use of this AFG to treat either PHN or
PMPS.

Translated title of the contributionBehandling af kroniske smerter med fedttransplantation
Original languageEnglish
Awarding Institution
  • University of Southern Denmark
Supervisors/Advisors
  • Sørensen, Jens Ahm, Principal supervisor
  • Thomsen, Jørn Bo, Co-supervisor
  • Rose, Michael, Supervisor
Date of defence31. Mar 2022
Publisher
DOIs
Publication statusPublished - 26. Mar 2022

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