Baseline cardiac troponin t levels are elevated in subjects with untreated diabetes mellitus

A cross-sectional study

M Pareek, M L Nielsen, M Leósdóttir, P M Nilsson, M H Olsen

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Abstract

Objective: Cardiac troponins are biomarkers of myocardial injury and serve both diagnostic and prognostic purposes. Even mild elevations represent subclinical myocardial damage in the general population. The objective of this study was to investigate the relationship between glucometabolic status and cardiac troponin T in middle-aged or older apparently healthy subjects. Design and method: We examined cross-sectional associations between highsensitivity cardiac troponin T (hsTnT) and FPG categorized as normal fasting glucose (NFG: FPG/=7.0mmol/L), in 535 men and 226 women aged 56-79 years without overt cardiovascular disease who received no cardiovascular, antidiabetic or lipid lowering drugs, using multiple linear regression analysis. Results: FPG category (r = 0.159; p <0.001) was positively correlated with hsTnT. Mean hsTnT levels increased significantly with worsening glucometabolic status (NFG: 7.55 ng/L +/- standard deviation 3.99 ng/L; IFG: 8.09 ng/L +/- 6.81 ng/L; DM: 10.28 ng/L +/- 7.55 ng/L; p <0.001). Levels were significantly higher in subjects with DM compared to NFG (p <0.001) and IFG (p = 0.005), but there was no significant difference between subjects with NFG and IFG (p = 0.26). After adjusting for age and sex, FPG category remained significantly predictive of hsTnT (B = 1.08 [95% confidence interval (CI), 0.56-1.59]; p <0.001). After further adjusting for traditional cardiovascular risk factors, cystatin C levels, and electrocardiographic left ventricular hypertrophy (LVH) defined by the Sokolow-Lyon index and/or Cornell voltage-duration product,FPGcategory remained significantly associated with hsTnT (B = 0.87 [95% CI, 0.35-1.39]; p = 0.001), independently of age (B = 0.29 [95% CI, 0.22-0.36]; p <0.001), sex (B = 2.08 [95% CI, 1.20-2.95]; p <0.001), systolic blood pressure (B = 0.032 [95% CI, 0.012-0.051]; p = 0.001), and cystatin C (B = 3.69 [95% CI, 1.60-5.79]; p = 0.001). There was a significant interaction between FPG category and age (NFG: B= 0.22 [95% CI, 0.16-0.29]; IFG: B= 0.33 [95% CI, 0.18-0.48]; DM: B= 0.41 [95% CI, 0.20-0.62]; p = 0.03). Conclusions: In middle-aged or older apparently healthy subjects, untreated DM was associated with higher levels of hsTnT, independently of traditional cardiovascular risk factors. The importance of age increased with worsening glucometabolic status.
Original languageEnglish
Article number4B.07
JournalJournal of Hypertension
Volume33
Issue numberSuppl. 1
Pages (from-to)e54-e55
Number of pages1
ISSN0263-6352
DOIs
Publication statusPublished - 2015
Event25th European Meeting on Hypertension and Cardiovascular Protection - Milano, Italy
Duration: 12. Jun 201515. Jun 2015

Conference

Conference25th European Meeting on Hypertension and Cardiovascular Protection
CountryItaly
CityMilano
Period12/06/201515/06/2015

Cite this

Pareek, M ; Nielsen, M L ; Leósdóttir, M ; Nilsson, P M ; Olsen, M H. / Baseline cardiac troponin t levels are elevated in subjects with untreated diabetes mellitus : A cross-sectional study. In: Journal of Hypertension. 2015 ; Vol. 33, No. Suppl. 1. pp. e54-e55.
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title = "Baseline cardiac troponin t levels are elevated in subjects with untreated diabetes mellitus: A cross-sectional study",
abstract = "Objective: Cardiac troponins are biomarkers of myocardial injury and serve both diagnostic and prognostic purposes. Even mild elevations represent subclinical myocardial damage in the general population. The objective of this study was to investigate the relationship between glucometabolic status and cardiac troponin T in middle-aged or older apparently healthy subjects. Design and method: We examined cross-sectional associations between highsensitivity cardiac troponin T (hsTnT) and FPG categorized as normal fasting glucose (NFG: FPG/=7.0mmol/L), in 535 men and 226 women aged 56-79 years without overt cardiovascular disease who received no cardiovascular, antidiabetic or lipid lowering drugs, using multiple linear regression analysis. Results: FPG category (r = 0.159; p <0.001) was positively correlated with hsTnT. Mean hsTnT levels increased significantly with worsening glucometabolic status (NFG: 7.55 ng/L +/- standard deviation 3.99 ng/L; IFG: 8.09 ng/L +/- 6.81 ng/L; DM: 10.28 ng/L +/- 7.55 ng/L; p <0.001). Levels were significantly higher in subjects with DM compared to NFG (p <0.001) and IFG (p = 0.005), but there was no significant difference between subjects with NFG and IFG (p = 0.26). After adjusting for age and sex, FPG category remained significantly predictive of hsTnT (B = 1.08 [95{\%} confidence interval (CI), 0.56-1.59]; p <0.001). After further adjusting for traditional cardiovascular risk factors, cystatin C levels, and electrocardiographic left ventricular hypertrophy (LVH) defined by the Sokolow-Lyon index and/or Cornell voltage-duration product,FPGcategory remained significantly associated with hsTnT (B = 0.87 [95{\%} CI, 0.35-1.39]; p = 0.001), independently of age (B = 0.29 [95{\%} CI, 0.22-0.36]; p <0.001), sex (B = 2.08 [95{\%} CI, 1.20-2.95]; p <0.001), systolic blood pressure (B = 0.032 [95{\%} CI, 0.012-0.051]; p = 0.001), and cystatin C (B = 3.69 [95{\%} CI, 1.60-5.79]; p = 0.001). There was a significant interaction between FPG category and age (NFG: B= 0.22 [95{\%} CI, 0.16-0.29]; IFG: B= 0.33 [95{\%} CI, 0.18-0.48]; DM: B= 0.41 [95{\%} CI, 0.20-0.62]; p = 0.03). Conclusions: In middle-aged or older apparently healthy subjects, untreated DM was associated with higher levels of hsTnT, independently of traditional cardiovascular risk factors. The importance of age increased with worsening glucometabolic status.",
keywords = "*diabetes mellitus *cross- sectional study *European *hypertension *protection human heart muscle injury diet restriction normal human cardiovascular risk middle aged population cardiovascular disease female systolic blood pressure male electric potential heart left ventricle hypertrophy diagnosis confidence interval multiple linear regression analysis *troponin T cystatin C glucose antidiabetic agent antilipemic agent biological marker",
author = "M Pareek and Nielsen, {M L} and M Le{\'o}sd{\'o}ttir and Nilsson, {P M} and Olsen, {M H}",
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Baseline cardiac troponin t levels are elevated in subjects with untreated diabetes mellitus : A cross-sectional study. / Pareek, M; Nielsen, M L; Leósdóttir, M; Nilsson, P M; Olsen, M H.

In: Journal of Hypertension, Vol. 33, No. Suppl. 1, 4B.07, 2015, p. e54-e55.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

TY - ABST

T1 - Baseline cardiac troponin t levels are elevated in subjects with untreated diabetes mellitus

T2 - A cross-sectional study

AU - Pareek, M

AU - Nielsen, M L

AU - Leósdóttir, M

AU - Nilsson, P M

AU - Olsen, M H

PY - 2015

Y1 - 2015

N2 - Objective: Cardiac troponins are biomarkers of myocardial injury and serve both diagnostic and prognostic purposes. Even mild elevations represent subclinical myocardial damage in the general population. The objective of this study was to investigate the relationship between glucometabolic status and cardiac troponin T in middle-aged or older apparently healthy subjects. Design and method: We examined cross-sectional associations between highsensitivity cardiac troponin T (hsTnT) and FPG categorized as normal fasting glucose (NFG: FPG/=7.0mmol/L), in 535 men and 226 women aged 56-79 years without overt cardiovascular disease who received no cardiovascular, antidiabetic or lipid lowering drugs, using multiple linear regression analysis. Results: FPG category (r = 0.159; p <0.001) was positively correlated with hsTnT. Mean hsTnT levels increased significantly with worsening glucometabolic status (NFG: 7.55 ng/L +/- standard deviation 3.99 ng/L; IFG: 8.09 ng/L +/- 6.81 ng/L; DM: 10.28 ng/L +/- 7.55 ng/L; p <0.001). Levels were significantly higher in subjects with DM compared to NFG (p <0.001) and IFG (p = 0.005), but there was no significant difference between subjects with NFG and IFG (p = 0.26). After adjusting for age and sex, FPG category remained significantly predictive of hsTnT (B = 1.08 [95% confidence interval (CI), 0.56-1.59]; p <0.001). After further adjusting for traditional cardiovascular risk factors, cystatin C levels, and electrocardiographic left ventricular hypertrophy (LVH) defined by the Sokolow-Lyon index and/or Cornell voltage-duration product,FPGcategory remained significantly associated with hsTnT (B = 0.87 [95% CI, 0.35-1.39]; p = 0.001), independently of age (B = 0.29 [95% CI, 0.22-0.36]; p <0.001), sex (B = 2.08 [95% CI, 1.20-2.95]; p <0.001), systolic blood pressure (B = 0.032 [95% CI, 0.012-0.051]; p = 0.001), and cystatin C (B = 3.69 [95% CI, 1.60-5.79]; p = 0.001). There was a significant interaction between FPG category and age (NFG: B= 0.22 [95% CI, 0.16-0.29]; IFG: B= 0.33 [95% CI, 0.18-0.48]; DM: B= 0.41 [95% CI, 0.20-0.62]; p = 0.03). Conclusions: In middle-aged or older apparently healthy subjects, untreated DM was associated with higher levels of hsTnT, independently of traditional cardiovascular risk factors. The importance of age increased with worsening glucometabolic status.

AB - Objective: Cardiac troponins are biomarkers of myocardial injury and serve both diagnostic and prognostic purposes. Even mild elevations represent subclinical myocardial damage in the general population. The objective of this study was to investigate the relationship between glucometabolic status and cardiac troponin T in middle-aged or older apparently healthy subjects. Design and method: We examined cross-sectional associations between highsensitivity cardiac troponin T (hsTnT) and FPG categorized as normal fasting glucose (NFG: FPG/=7.0mmol/L), in 535 men and 226 women aged 56-79 years without overt cardiovascular disease who received no cardiovascular, antidiabetic or lipid lowering drugs, using multiple linear regression analysis. Results: FPG category (r = 0.159; p <0.001) was positively correlated with hsTnT. Mean hsTnT levels increased significantly with worsening glucometabolic status (NFG: 7.55 ng/L +/- standard deviation 3.99 ng/L; IFG: 8.09 ng/L +/- 6.81 ng/L; DM: 10.28 ng/L +/- 7.55 ng/L; p <0.001). Levels were significantly higher in subjects with DM compared to NFG (p <0.001) and IFG (p = 0.005), but there was no significant difference between subjects with NFG and IFG (p = 0.26). After adjusting for age and sex, FPG category remained significantly predictive of hsTnT (B = 1.08 [95% confidence interval (CI), 0.56-1.59]; p <0.001). After further adjusting for traditional cardiovascular risk factors, cystatin C levels, and electrocardiographic left ventricular hypertrophy (LVH) defined by the Sokolow-Lyon index and/or Cornell voltage-duration product,FPGcategory remained significantly associated with hsTnT (B = 0.87 [95% CI, 0.35-1.39]; p = 0.001), independently of age (B = 0.29 [95% CI, 0.22-0.36]; p <0.001), sex (B = 2.08 [95% CI, 1.20-2.95]; p <0.001), systolic blood pressure (B = 0.032 [95% CI, 0.012-0.051]; p = 0.001), and cystatin C (B = 3.69 [95% CI, 1.60-5.79]; p = 0.001). There was a significant interaction between FPG category and age (NFG: B= 0.22 [95% CI, 0.16-0.29]; IFG: B= 0.33 [95% CI, 0.18-0.48]; DM: B= 0.41 [95% CI, 0.20-0.62]; p = 0.03). Conclusions: In middle-aged or older apparently healthy subjects, untreated DM was associated with higher levels of hsTnT, independently of traditional cardiovascular risk factors. The importance of age increased with worsening glucometabolic status.

KW - diabetes mellitus cross- sectional study European hypertension protection human heart muscle injury diet restriction normal human cardiovascular risk middle aged population cardiovascular disease female systolic blood pressure male electric potential hear

U2 - 10.1097/01.hjh.0000467491.14601.38

DO - 10.1097/01.hjh.0000467491.14601.38

M3 - Conference abstract in journal

VL - 33

SP - e54-e55

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - Suppl. 1

M1 - 4B.07

ER -