Az LGI1-encephalitis hazánkban elsőként diagnosztizált esete

Translated title of the contribution: LGI1 ENCEPHALITIS: THE FIRST HUNGARIAN PATIENT

Mónika Szőts, Annamária Marton, Zsolt Illés, Gábor Bajzik, Ferenc Nagy

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In the recent years, it has been increasingly recognised that in a group of limbic encephalitis antibodies are directed against the scaffolding protein LGI1 (Leucine-rich glioma inactivated 1), which is part of the voltage gated potassium channel (VGKC) complex on neural synapses. Patients present with seizures and subacute history of neuropsychiatric symptoms, including psychosis and changes in memory, cognition, behaviour. Faciobrachial dystonic seizures can be observed, which are highly characteristic for LGI1 encephalitis. MRI shows medial temporal abnormalities in more than half of the cases. CSF evaluation is usually normal. Hyponatremia is frequently associated and may confuse the initial diagnosis. Early recognition and prompt initiation of immunotherapies are of great importance. The clinical improvements often correlate with the antibody levels. We present the case of a 64-year old man, who responded quickly to plasma exchange and major improvement was noted within few weeks.

Original languageUndefined/Unknown
JournalIdeggyogyaszati Szemle
Volume68
Issue number7-8
Pages (from-to)279-285
ISSN0019-1442
DOIs
Publication statusPublished - 2015

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Leucine
Glioma
Limbic Encephalitis
Plasma Exchange
Hyponatremia
Cognition
Proteins
Recognition (Psychology)

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Szőts, Mónika ; Marton, Annamária ; Illés, Zsolt ; Bajzik, Gábor ; Nagy, Ferenc. / Az LGI1-encephalitis hazánkban elsőként diagnosztizált esete. In: Ideggyogyaszati Szemle. 2015 ; Vol. 68, No. 7-8. pp. 279-285.
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abstract = "In the recent years, it has been increasingly recognised that in a group of limbic encephalitis antibodies are directed against the scaffolding protein LGI1 (Leucine-rich glioma inactivated 1), which is part of the voltage gated potassium channel (VGKC) complex on neural synapses. Patients present with seizures and subacute history of neuropsychiatric symptoms, including psychosis and changes in memory, cognition, behaviour. Faciobrachial dystonic seizures can be observed, which are highly characteristic for LGI1 encephalitis. MRI shows medial temporal abnormalities in more than half of the cases. CSF evaluation is usually normal. Hyponatremia is frequently associated and may confuse the initial diagnosis. Early recognition and prompt initiation of immunotherapies are of great importance. The clinical improvements often correlate with the antibody levels. We present the case of a 64-year old man, who responded quickly to plasma exchange and major improvement was noted within few weeks.",
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Az LGI1-encephalitis hazánkban elsőként diagnosztizált esete. / Szőts, Mónika; Marton, Annamária; Illés, Zsolt; Bajzik, Gábor; Nagy, Ferenc.

In: Ideggyogyaszati Szemle, Vol. 68, No. 7-8, 2015, p. 279-285.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Az LGI1-encephalitis hazánkban elsőként diagnosztizált esete

AU - Szőts, Mónika

AU - Marton, Annamária

AU - Illés, Zsolt

AU - Bajzik, Gábor

AU - Nagy, Ferenc

PY - 2015

Y1 - 2015

N2 - In the recent years, it has been increasingly recognised that in a group of limbic encephalitis antibodies are directed against the scaffolding protein LGI1 (Leucine-rich glioma inactivated 1), which is part of the voltage gated potassium channel (VGKC) complex on neural synapses. Patients present with seizures and subacute history of neuropsychiatric symptoms, including psychosis and changes in memory, cognition, behaviour. Faciobrachial dystonic seizures can be observed, which are highly characteristic for LGI1 encephalitis. MRI shows medial temporal abnormalities in more than half of the cases. CSF evaluation is usually normal. Hyponatremia is frequently associated and may confuse the initial diagnosis. Early recognition and prompt initiation of immunotherapies are of great importance. The clinical improvements often correlate with the antibody levels. We present the case of a 64-year old man, who responded quickly to plasma exchange and major improvement was noted within few weeks.

AB - In the recent years, it has been increasingly recognised that in a group of limbic encephalitis antibodies are directed against the scaffolding protein LGI1 (Leucine-rich glioma inactivated 1), which is part of the voltage gated potassium channel (VGKC) complex on neural synapses. Patients present with seizures and subacute history of neuropsychiatric symptoms, including psychosis and changes in memory, cognition, behaviour. Faciobrachial dystonic seizures can be observed, which are highly characteristic for LGI1 encephalitis. MRI shows medial temporal abnormalities in more than half of the cases. CSF evaluation is usually normal. Hyponatremia is frequently associated and may confuse the initial diagnosis. Early recognition and prompt initiation of immunotherapies are of great importance. The clinical improvements often correlate with the antibody levels. We present the case of a 64-year old man, who responded quickly to plasma exchange and major improvement was noted within few weeks.

KW - Autoantibodies

KW - Cognition

KW - Diagnosis, Differential

KW - Early Diagnosis

KW - Humans

KW - Hungary

KW - Limbic Encephalitis

KW - Magnetic Resonance Imaging

KW - Male

KW - Memory

KW - Middle Aged

KW - Plasma Exchange

KW - Potassium Channels, Voltage-Gated

KW - Proteins

KW - Social Behavior

KW - Temporal Lobe

U2 - 10.18071/isz.68.0279

DO - 10.18071/isz.68.0279

M3 - Tidsskriftartikel

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JO - Ideggyogyaszati Szemle

JF - Ideggyogyaszati Szemle

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ER -