Improving national surveillance of Lyme neuroborreliosis in Denmark through electronic reporting of specific antibody index testing from 2010 to 2012

Ram Benny Dessau, L Espenhain, K Mølbak, T G Krause, M Voldstedlund

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Abstract

Our aim was to evaluate the results of automated surveillance of Lyme neuroborreliosis (LNB) in Denmark using the national microbiology database (MiBa), and to describe the epidemiology of laboratory-confirmed LNB at a national level. MiBa-based surveillance includes electronic transfer of laboratory results, in contrast to the statutory surveillance based on manually processed notifications. Antibody index (AI) testing is the recommend laboratory test to support the diagnosis of LNB in Denmark. In the period from 2010 to 2012, 217 clinical cases of LNB were notified to the statutory surveillance system, while 533 cases were reported AI positive by the MiBa system. Thirty-five unconfirmed cases (29 AI-negative and 6 not tested) were notified, but not captured by MiBa. Using MiBa, the number of reported cases was increased almost 2.5 times. Furthermore, the reporting was timelier (median lag time: 6 vs 58 days). Average annual incidence of AI-confirmed LNB in Denmark was 3.2/100,000 population and incidences stratified by municipality ranged from none to above 10/100,000. This is the first study reporting nationwide incidence of LNB using objective laboratory criteria. Laboratory-based surveillance with electronic data-transfer was more accurate, complete and timely compared to the surveillance based on manually processed notifications. We propose using AI test results for LNB surveillance instead of clinical reporting.

Translated title of the contributionAutomatiseret elektronisk overvågning af Lyme Neuroborreliose i Danmark ved brug af laboratorie data.: Incidens data fra 2010-2012
Original languageEnglish
Article number4
JournalEurosurveillance (Online Edition)
Volume20
Issue number28
ISSN1025-496X
DOIs
Publication statusPublished - 16. Jul 2015

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Bacterial
  • Borrelia
  • Child
  • Child, Preschool
  • Cohort Studies
  • Denmark
  • Disease Notification
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Lyme Disease
  • Lyme Neuroborreliosis
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Population Surveillance
  • Young Adult

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  • Activities

    • 1 Membership of commitees, commissions, boards, councils, associations, organisations, or similar

    MIBA - Den danske mikrobiologi database (External organisation)

    Ram Benny Dessau (Member)

    20102017

    Activity: MembershipMembership of commitees, commissions, boards, councils, associations, organisations, or similar

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