Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders

A literature review

Sareh Shahmohammadi, Rozita Doosti, Abootorab Shahmohammadi, Seyed Ehsan Mohammadianinejad, Mohammad Ali Sahraian, Amir Reza Azimi, Mohammad Hossein Harirchian, Nasrin Asgari, Abdorreza Naser Moghadasi*

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

Abstract

Introduction: Neuromyelitis Optica (NMO) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS) which predominantly involves optic nerves and spinal cord. Since the introduction of Neuromyelitis Optica Spectrum Disorders (NMOSD) as a separate entity, there have been many reports on its association with other disorders including systemic and organ-specific autoimmune diseases. Here, we reviewed other immune-mediated diseases associated with NMOSD and tried to categorize them. Methods: The present review was conducted using the PUBMED database based on papers from 1976 (i.e., since the first NMO comorbidity with SLE was reported) to 2017. We included all articles published in English. The keywords utilized included Neuromyelitis optica, Neuromyelitis Optica Spectrum Disorders, Devic's disease, in combination with comorbidity or comorbidities. Results: Diseases with immune-based pathogenesis are the most frequently reported co-morbidities associated with NMOSD, most of which are antibody-mediated diseases. According to literature, Sjogren's Syndrome (SS) and Systemic Lupus Erythematosus (SLE) are the most frequently reported diseases associated with NMOSD among systemic autoimmune diseases. Further, myasthenia gravis in neurological and autoimmune thyroid diseases in non-neurological organ-specific autoimmune diseases are the most reported comorbidities associated with NMOSD in the literature. Conclusions: NMOSD may be associated with a variety of different types of autoimmune diseases. Therefore, systemic or laboratory signs which are not typical for NMOSD should be properly investigated to exclude other associated comorbidities. These comorbidities may affect the treatment strategy and may improve the patients' care and management.

Original languageEnglish
JournalMultiple Sclerosis and Related Disorders
Volume27
Pages (from-to)350-363
ISSN2211-0348
DOIs
Publication statusPublished - Jan 2019

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Neuromyelitis Optica
Comorbidity
Immune System Diseases
Patient Care Management
Sjogren's Syndrome
Optic Nerve

Keywords

  • Autoimmune diseases
  • Comorbidities
  • Neuromyelitis Optica Spectrum Disorders (NMOSD)

Cite this

Shahmohammadi, S., Doosti, R., Shahmohammadi, A., Mohammadianinejad, S. E., Sahraian, M. A., Azimi, A. R., ... Naser Moghadasi, A. (2019). Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review. Multiple Sclerosis and Related Disorders, 27, 350-363. https://doi.org/10.1016/j.msard.2018.11.008
Shahmohammadi, Sareh ; Doosti, Rozita ; Shahmohammadi, Abootorab ; Mohammadianinejad, Seyed Ehsan ; Sahraian, Mohammad Ali ; Azimi, Amir Reza ; Harirchian, Mohammad Hossein ; Asgari, Nasrin ; Naser Moghadasi, Abdorreza. / Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders : A literature review. In: Multiple Sclerosis and Related Disorders. 2019 ; Vol. 27. pp. 350-363.
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title = "Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review",
abstract = "Introduction: Neuromyelitis Optica (NMO) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS) which predominantly involves optic nerves and spinal cord. Since the introduction of Neuromyelitis Optica Spectrum Disorders (NMOSD) as a separate entity, there have been many reports on its association with other disorders including systemic and organ-specific autoimmune diseases. Here, we reviewed other immune-mediated diseases associated with NMOSD and tried to categorize them. Methods: The present review was conducted using the PUBMED database based on papers from 1976 (i.e., since the first NMO comorbidity with SLE was reported) to 2017. We included all articles published in English. The keywords utilized included Neuromyelitis optica, Neuromyelitis Optica Spectrum Disorders, Devic's disease, in combination with comorbidity or comorbidities. Results: Diseases with immune-based pathogenesis are the most frequently reported co-morbidities associated with NMOSD, most of which are antibody-mediated diseases. According to literature, Sjogren's Syndrome (SS) and Systemic Lupus Erythematosus (SLE) are the most frequently reported diseases associated with NMOSD among systemic autoimmune diseases. Further, myasthenia gravis in neurological and autoimmune thyroid diseases in non-neurological organ-specific autoimmune diseases are the most reported comorbidities associated with NMOSD in the literature. Conclusions: NMOSD may be associated with a variety of different types of autoimmune diseases. Therefore, systemic or laboratory signs which are not typical for NMOSD should be properly investigated to exclude other associated comorbidities. These comorbidities may affect the treatment strategy and may improve the patients' care and management.",
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author = "Sareh Shahmohammadi and Rozita Doosti and Abootorab Shahmohammadi and Mohammadianinejad, {Seyed Ehsan} and Sahraian, {Mohammad Ali} and Azimi, {Amir Reza} and Harirchian, {Mohammad Hossein} and Nasrin Asgari and {Naser Moghadasi}, Abdorreza",
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Shahmohammadi, S, Doosti, R, Shahmohammadi, A, Mohammadianinejad, SE, Sahraian, MA, Azimi, AR, Harirchian, MH, Asgari, N & Naser Moghadasi, A 2019, 'Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review', Multiple Sclerosis and Related Disorders, vol. 27, pp. 350-363. https://doi.org/10.1016/j.msard.2018.11.008

Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders : A literature review. / Shahmohammadi, Sareh; Doosti, Rozita; Shahmohammadi, Abootorab; Mohammadianinejad, Seyed Ehsan; Sahraian, Mohammad Ali; Azimi, Amir Reza; Harirchian, Mohammad Hossein; Asgari, Nasrin; Naser Moghadasi, Abdorreza.

In: Multiple Sclerosis and Related Disorders, Vol. 27, 01.2019, p. 350-363.

Research output: Contribution to journalReviewResearchpeer-review

TY - JOUR

T1 - Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders

T2 - A literature review

AU - Shahmohammadi, Sareh

AU - Doosti, Rozita

AU - Shahmohammadi, Abootorab

AU - Mohammadianinejad, Seyed Ehsan

AU - Sahraian, Mohammad Ali

AU - Azimi, Amir Reza

AU - Harirchian, Mohammad Hossein

AU - Asgari, Nasrin

AU - Naser Moghadasi, Abdorreza

PY - 2019/1

Y1 - 2019/1

N2 - Introduction: Neuromyelitis Optica (NMO) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS) which predominantly involves optic nerves and spinal cord. Since the introduction of Neuromyelitis Optica Spectrum Disorders (NMOSD) as a separate entity, there have been many reports on its association with other disorders including systemic and organ-specific autoimmune diseases. Here, we reviewed other immune-mediated diseases associated with NMOSD and tried to categorize them. Methods: The present review was conducted using the PUBMED database based on papers from 1976 (i.e., since the first NMO comorbidity with SLE was reported) to 2017. We included all articles published in English. The keywords utilized included Neuromyelitis optica, Neuromyelitis Optica Spectrum Disorders, Devic's disease, in combination with comorbidity or comorbidities. Results: Diseases with immune-based pathogenesis are the most frequently reported co-morbidities associated with NMOSD, most of which are antibody-mediated diseases. According to literature, Sjogren's Syndrome (SS) and Systemic Lupus Erythematosus (SLE) are the most frequently reported diseases associated with NMOSD among systemic autoimmune diseases. Further, myasthenia gravis in neurological and autoimmune thyroid diseases in non-neurological organ-specific autoimmune diseases are the most reported comorbidities associated with NMOSD in the literature. Conclusions: NMOSD may be associated with a variety of different types of autoimmune diseases. Therefore, systemic or laboratory signs which are not typical for NMOSD should be properly investigated to exclude other associated comorbidities. These comorbidities may affect the treatment strategy and may improve the patients' care and management.

AB - Introduction: Neuromyelitis Optica (NMO) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS) which predominantly involves optic nerves and spinal cord. Since the introduction of Neuromyelitis Optica Spectrum Disorders (NMOSD) as a separate entity, there have been many reports on its association with other disorders including systemic and organ-specific autoimmune diseases. Here, we reviewed other immune-mediated diseases associated with NMOSD and tried to categorize them. Methods: The present review was conducted using the PUBMED database based on papers from 1976 (i.e., since the first NMO comorbidity with SLE was reported) to 2017. We included all articles published in English. The keywords utilized included Neuromyelitis optica, Neuromyelitis Optica Spectrum Disorders, Devic's disease, in combination with comorbidity or comorbidities. Results: Diseases with immune-based pathogenesis are the most frequently reported co-morbidities associated with NMOSD, most of which are antibody-mediated diseases. According to literature, Sjogren's Syndrome (SS) and Systemic Lupus Erythematosus (SLE) are the most frequently reported diseases associated with NMOSD among systemic autoimmune diseases. Further, myasthenia gravis in neurological and autoimmune thyroid diseases in non-neurological organ-specific autoimmune diseases are the most reported comorbidities associated with NMOSD in the literature. Conclusions: NMOSD may be associated with a variety of different types of autoimmune diseases. Therefore, systemic or laboratory signs which are not typical for NMOSD should be properly investigated to exclude other associated comorbidities. These comorbidities may affect the treatment strategy and may improve the patients' care and management.

KW - Autoimmune diseases

KW - Comorbidities

KW - Neuromyelitis Optica Spectrum Disorders (NMOSD)

U2 - 10.1016/j.msard.2018.11.008

DO - 10.1016/j.msard.2018.11.008

M3 - Review

VL - 27

SP - 350

EP - 363

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

SN - 2211-0348

ER -

Shahmohammadi S, Doosti R, Shahmohammadi A, Mohammadianinejad SE, Sahraian MA, Azimi AR et al. Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review. Multiple Sclerosis and Related Disorders. 2019 Jan;27:350-363. https://doi.org/10.1016/j.msard.2018.11.008