Associations between airway hyperresponsiveness, obesity, and lipoproteins in a longitudinal cohort

Finn Rasmussen, Robert Hancox, Parameswaran Nair, Henrik Steen Hansen, Hans Christian Siersted, Mads Nybo

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background Epidemiological data have linked obesity with an increased risk of asthma, but the mechanisms responsible for this relationship remain unknown. One possible mechanism, which has received little attention, could be the effect of cholesterol metabolism on airway smooth muscle function. The present study investigated the association between airway hyperresponsiveness (AHR) to methacholine and body mass index (BMI) and plasma lipoproteins [low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol]. Methods Associations between AHR, BMI and plasma lipoproteins were assessed in a population-based cohort at ages 14 and 20 years. Results In unadjusted analyses, higher LDL cholesterol levels at age 14 were associated with AHR at age 20 in both sexes (P
Original languageEnglish
JournalClinical Respiratory Journal
Volume7
Issue number3
Pages (from-to)268-275
ISSN1752-6981
DOIs
Publication statusPublished - 2013

Keywords

  • airway hyperresponsiveness cholesterol cohort studies inflammation obesity BODY-MASS INDEX C-REACTIVE PROTEIN ODENSE SCHOOLCHILD LUNG-FUNCTION ASTHMA POPULATION METHACHOLINE CHOLESTEROL CHILDHOOD CHILDREN

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