Associations between airway hyperresponsiveness, obesity, and lipoproteins in a longitudinal cohort

Finn Rasmussen; Robert Hancox; Parameswaran Nair; Henrik Steen Hansen; Hans Christian Siersted; Mads Nybo

doi:10.1111/crj.12000

Associations between airway hyperresponsiveness, obesity, and lipoproteins in a longitudinal cohort

Finn Rasmussen, Robert Hancox, Parameswaran Nair, Henrik Steen Hansen, Hans Christian Siersted, Mads Nybo

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Background Epidemiological data have linked obesity with an increased risk of asthma, but the mechanisms responsible for this relationship remain unknown. One possible mechanism, which has received little attention, could be the effect of cholesterol metabolism on airway smooth muscle function. The present study investigated the association between airway hyperresponsiveness (AHR) to methacholine and body mass index (BMI) and plasma lipoproteins [low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol]. Methods Associations between AHR, BMI and plasma lipoproteins were assessed in a population-based cohort at ages 14 and 20 years. Results In unadjusted analyses, higher LDL cholesterol levels at age 14 were associated with AHR at age 20 in both sexes (P

Original language	English
Journal	Clinical Respiratory Journal
Volume	7
Issue number	3
Pages (from-to)	268-275
ISSN	1752-6981
DOIs	https://doi.org/10.1111/crj.12000
Publication status	Published - 2013

Keywords

airway hyperresponsiveness cholesterol cohort studies inflammation obesity BODY-MASS INDEX C-REACTIVE PROTEIN ODENSE SCHOOLCHILD LUNG-FUNCTION ASTHMA POPULATION METHACHOLINE CHOLESTEROL CHILDHOOD CHILDREN

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10.1111/crj.12000

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@article{8a61afe0159649f98d7229bb067d724d,

title = "Associations between airway hyperresponsiveness, obesity, and lipoproteins in a longitudinal cohort",

abstract = "Background Epidemiological data have linked obesity with an increased risk of asthma, but the mechanisms responsible for this relationship remain unknown. One possible mechanism, which has received little attention, could be the effect of cholesterol metabolism on airway smooth muscle function. The present study investigated the association between airway hyperresponsiveness (AHR) to methacholine and body mass index (BMI) and plasma lipoproteins [low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol]. Methods Associations between AHR, BMI and plasma lipoproteins were assessed in a population-based cohort at ages 14 and 20 years. Results In unadjusted analyses, higher LDL cholesterol levels at age 14 were associated with AHR at age 20 in both sexes (P",

keywords = "airway hyperresponsiveness cholesterol cohort studies inflammation obesity BODY-MASS INDEX C-REACTIVE PROTEIN ODENSE SCHOOLCHILD LUNG-FUNCTION ASTHMA POPULATION METHACHOLINE CHOLESTEROL CHILDHOOD CHILDREN",

author = "Finn Rasmussen and Robert Hancox and Parameswaran Nair and Hansen, {Henrik Steen} and Siersted, {Hans Christian} and Mads Nybo",

note = "E-pub 12 Oct 2012 ",

year = "2013",

doi = "10.1111/crj.12000",

language = "English",

volume = "7",

pages = "268--275",

journal = "Clinical Respiratory Journal",

issn = "1752-6981",

publisher = "Wiley-Blackwell",

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Associations between airway hyperresponsiveness, obesity, and lipoproteins in a longitudinal cohort. / Rasmussen, Finn; Hancox, Robert; Nair, Parameswaran; Hansen, Henrik Steen; Siersted, Hans Christian; Nybo, Mads.

In: Clinical Respiratory Journal, Vol. 7, No. 3, 2013, p. 268-275.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Associations between airway hyperresponsiveness, obesity, and lipoproteins in a longitudinal cohort

AU - Rasmussen, Finn

AU - Hancox, Robert

AU - Nair, Parameswaran

AU - Hansen, Henrik Steen

AU - Siersted, Hans Christian

AU - Nybo, Mads

N1 - E-pub 12 Oct 2012

PY - 2013

Y1 - 2013

N2 - Background Epidemiological data have linked obesity with an increased risk of asthma, but the mechanisms responsible for this relationship remain unknown. One possible mechanism, which has received little attention, could be the effect of cholesterol metabolism on airway smooth muscle function. The present study investigated the association between airway hyperresponsiveness (AHR) to methacholine and body mass index (BMI) and plasma lipoproteins [low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol]. Methods Associations between AHR, BMI and plasma lipoproteins were assessed in a population-based cohort at ages 14 and 20 years. Results In unadjusted analyses, higher LDL cholesterol levels at age 14 were associated with AHR at age 20 in both sexes (P

AB - Background Epidemiological data have linked obesity with an increased risk of asthma, but the mechanisms responsible for this relationship remain unknown. One possible mechanism, which has received little attention, could be the effect of cholesterol metabolism on airway smooth muscle function. The present study investigated the association between airway hyperresponsiveness (AHR) to methacholine and body mass index (BMI) and plasma lipoproteins [low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol]. Methods Associations between AHR, BMI and plasma lipoproteins were assessed in a population-based cohort at ages 14 and 20 years. Results In unadjusted analyses, higher LDL cholesterol levels at age 14 were associated with AHR at age 20 in both sexes (P

KW - airway hyperresponsiveness cholesterol cohort studies inflammation obesity BODY-MASS INDEX C-REACTIVE PROTEIN ODENSE SCHOOLCHILD LUNG-FUNCTION ASTHMA POPULATION METHACHOLINE CHOLESTEROL CHILDHOOD CHILDREN

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DO - 10.1111/crj.12000

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JO - Clinical Respiratory Journal

JF - Clinical Respiratory Journal

SN - 1752-6981

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