Association of sensory phenotype with quality of life, functionality, and emotional well-being in patients suffering from neuropathic pain

Janne Gierthmühlen, Johann Böhmer, Nadine Attal, Didier Bouhassira, Rainer Freynhagen, Maija Haanpää, Per Hansson, Troels Staehelin Jensen, Jeffrey Kennedy, Christoph Maier, Andrew S C Rice, Juliane Sachau, Märta Segerdahl, Sören Sindrup, Thomas Tölle, Rolf-Detlef Treede, Lise Ventzel, Jan Vollert, Ralf Baron

Research output: Contribution to journalJournal articleResearchpeer-review

31 Downloads (Pure)


ABSTRACT: Neuropathic pain highly affects quality of life, well-being, and function. It has recently been shown based on cluster analysis studies that most patients with neuropathic pain may be categorized into 1 of 3 sensory phenotypes: sensory loss, mechanical hyperalgesia, and thermal hyperalgesia. If these phenotypes reflect underlying pathophysiological mechanisms, they may be more relevant for patient management than underlying neurological diagnosis or pain intensity. The aim of this study was thus to examine the impact of these sensory phenotypes on mental health, functionality, and quality of life. Data of 433 patients from the IMI/EuroPain network database were analyzed, and results of HADS-D/A, Pain Catastrophizing Scale, Euro Quality of Life 5D/-VAS, Brief Pain Inventory, and Graded Chronic Pain Scale between the sensory phenotypes were compared using multiple regression analysis. There was no difference in chronic pain grade, pain intensity, depression, or anxiety scores between phenotypes. Pain interference (Brief Pain Inventory) was higher (P = 0.002); self-reported health state lower (Euro Quality of Life 5D VAS, P = 0.02); and problems regarding mobility (P = 0.008), usual activities (P = 0.004), and self-care (P = 0.039) more prominent (EQ5-D) in the sensory loss compared with the thermal hyperalgesia phenotype. Patients with sensory loss also showed higher pain catastrophizing scores (P = 0.006 and 0.022, respectively) compared with the 2 other groups. Sensory phenotype is associated with the impact of neuropathic pain conditions on well-being, daily functionality, and quality of life but is less associated with pain intensity. These results suggest that the somatosensory phenotype should be considered for personalized pain management.

Original languageEnglish
Issue number7
Pages (from-to)1378-1387
Publication statusPublished - 1. Jul 2022


  • Chronic Pain
  • Humans
  • Hyperalgesia
  • Neuralgia
  • Phenotype
  • Quality of Life/psychology
  • Sensory phenotype
  • PRO
  • Emotional well-being
  • Neuropathic pain
  • Quality of life
  • QST
  • Functionality


Dive into the research topics of 'Association of sensory phenotype with quality of life, functionality, and emotional well-being in patients suffering from neuropathic pain'. Together they form a unique fingerprint.

Cite this