Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study

Nanna Ýr Arnardóttir, A Koster, Dane R Van Domelen, Robert J Brychta, P. Caserotti, Gudny Eiriksdottir, Johanna Eyrun Sverrisdottir, SB Sigurdsson, Erlingur Jóhannsson, K. Y. Chen, V Gudnason, T. B. Harris, L J Launer, Thórarinn Sveinsson

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Many studies have examined the hypothesis that greater participation in physical activity (PA) is associated with less brain atrophy. Here we examine, in a sub-sample (n = 352, mean age 79.1 years) of the Age, Gene/Environment Susceptibility-Reykjavik Study cohort, the association of the baseline and 5-year change in magnetic resonance imaging (MRI)-derived volumes of gray matter (GM) and white matter (WM) to active and sedentary behavior (SB) measured at the end of the 5-year period by a hip-worn accelerometer for seven consecutive days. More GM (beta = 0.11; p = 0.044) and WM (beta = 0.11; p = 0.030) at baseline was associated with more total physical activity (TPA). Also, when adjusting for baseline values, the 5-year change in GM (beta = 0.14; p = 0.0037) and WM (beta = 0.11; p = 0.030) was associated with TPA. The 5-year change in WM was associated with SB (p = 0.11; p = 0.0007). These data suggest that objectively measured PA and SB late in life are associated with current and prior cross-sectional measures of brain atrophy, and that change over time is associated with PA and SB in expected directions. (C) 2015 Elsevier B.V. All rights reserved.
Original languageEnglish
JournalBehavioural Brain Research
Volume296
Pages (from-to)118-124
ISSN0166-4328
DOIs
Publication statusPublished - 2016

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Bibliographical note

ISI Document Delivery No.: CY0EL Times Cited: 2 Cited Reference Count: 66 Arnardottir, Nanna Yr Koster, Annemarie Van Domelen, Dane R. Brychta, Robert J. Caserotti, Paolo Eiriksdottir, Gudny Sverrisdottir, Johanna E. Sigurdsson, Sigurdur Johannsson, Erlingur Chen, Kong Y. Gudnason, Vilmundur Harris, Tamara B. Launer, Lenore J. Sveinsson, Thorarinn Koster, Annemarie/E-7438-2010; Chen, Kong/0000-0002-0306-1904 NIA [N01-AG-1-2100]; NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association); Althingi (the Icelandic Parliament); National Science Foundation Graduate Research Fellowship [DGE-0940903]; National Institutes of Health Intramural Research Program [Z01 DK071013, Z01 DK071014] This study has been funded by NIA contract N01-AG-1-2100, the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament). This work was also supported by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-0940903 and by the National Institutes of Health Intramural Research Program, grant number: Z01 DK071013 and Z01 DK071014 to RJB and KYC. Thor Aspelund is acknowledged for statistical consultation. The researchers are indebted to the participants for their willingness to participate in the study. 2 18 Elsevier science bv Amsterdam 1872-7549

Keywords

  • Physical activity Sedentary behavior Brain atrophy Elderly MRI white-matter integrity cognitive decline united-states tissue volumes aging humans risk-factors exercise health atrophy population Behavioral Sciences Neurosciences & Neurology

Cite this

Arnardóttir, Nanna Ýr ; Koster, A ; Van Domelen, Dane R ; Brychta, Robert J ; Caserotti, P. ; Eiriksdottir, Gudny ; Sverrisdottir, Johanna Eyrun ; Sigurdsson, SB ; Jóhannsson, Erlingur ; Chen, K. Y. ; Gudnason, V ; Harris, T. B. ; Launer, L J ; Sveinsson, Thórarinn. / Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults : Age, Gene/Environment Susceptibility-Reykjavik Study. In: Behavioural Brain Research. 2016 ; Vol. 296. pp. 118-124.
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abstract = "Many studies have examined the hypothesis that greater participation in physical activity (PA) is associated with less brain atrophy. Here we examine, in a sub-sample (n = 352, mean age 79.1 years) of the Age, Gene/Environment Susceptibility-Reykjavik Study cohort, the association of the baseline and 5-year change in magnetic resonance imaging (MRI)-derived volumes of gray matter (GM) and white matter (WM) to active and sedentary behavior (SB) measured at the end of the 5-year period by a hip-worn accelerometer for seven consecutive days. More GM (beta = 0.11; p = 0.044) and WM (beta = 0.11; p = 0.030) at baseline was associated with more total physical activity (TPA). Also, when adjusting for baseline values, the 5-year change in GM (beta = 0.14; p = 0.0037) and WM (beta = 0.11; p = 0.030) was associated with TPA. The 5-year change in WM was associated with SB (p = 0.11; p = 0.0007). These data suggest that objectively measured PA and SB late in life are associated with current and prior cross-sectional measures of brain atrophy, and that change over time is associated with PA and SB in expected directions. (C) 2015 Elsevier B.V. All rights reserved.",
keywords = "Physical activity Sedentary behavior Brain atrophy Elderly MRI white-matter integrity cognitive decline united-states tissue volumes aging humans risk-factors exercise health atrophy population Behavioral Sciences Neurosciences & Neurology",
author = "Arnard{\'o}ttir, {Nanna {\'Y}r} and A Koster and {Van Domelen}, {Dane R} and Brychta, {Robert J} and P. Caserotti and Gudny Eiriksdottir and Sverrisdottir, {Johanna Eyrun} and SB Sigurdsson and Erlingur J{\'o}hannsson and Chen, {K. Y.} and V Gudnason and Harris, {T. B.} and Launer, {L J} and Th{\'o}rarinn Sveinsson",
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Arnardóttir, NÝ, Koster, A, Van Domelen, DR, Brychta, RJ, Caserotti, P, Eiriksdottir, G, Sverrisdottir, JE, Sigurdsson, SB, Jóhannsson, E, Chen, KY, Gudnason, V, Harris, TB, Launer, LJ & Sveinsson, T 2016, 'Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study', Behavioural Brain Research, vol. 296, pp. 118-124. https://doi.org/10.1016/j.bbr.2015.09.005

Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults : Age, Gene/Environment Susceptibility-Reykjavik Study. / Arnardóttir, Nanna Ýr; Koster, A; Van Domelen, Dane R; Brychta, Robert J; Caserotti, P.; Eiriksdottir, Gudny; Sverrisdottir, Johanna Eyrun; Sigurdsson, SB; Jóhannsson, Erlingur; Chen, K. Y.; Gudnason, V; Harris, T. B.; Launer, L J; Sveinsson, Thórarinn.

In: Behavioural Brain Research, Vol. 296, 2016, p. 118-124.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults

T2 - Age, Gene/Environment Susceptibility-Reykjavik Study

AU - Arnardóttir, Nanna Ýr

AU - Koster, A

AU - Van Domelen, Dane R

AU - Brychta, Robert J

AU - Caserotti, P.

AU - Eiriksdottir, Gudny

AU - Sverrisdottir, Johanna Eyrun

AU - Sigurdsson, SB

AU - Jóhannsson, Erlingur

AU - Chen, K. Y.

AU - Gudnason, V

AU - Harris, T. B.

AU - Launer, L J

AU - Sveinsson, Thórarinn

N1 - ISI Document Delivery No.: CY0EL Times Cited: 2 Cited Reference Count: 66 Arnardottir, Nanna Yr Koster, Annemarie Van Domelen, Dane R. Brychta, Robert J. Caserotti, Paolo Eiriksdottir, Gudny Sverrisdottir, Johanna E. Sigurdsson, Sigurdur Johannsson, Erlingur Chen, Kong Y. Gudnason, Vilmundur Harris, Tamara B. Launer, Lenore J. Sveinsson, Thorarinn Koster, Annemarie/E-7438-2010; Chen, Kong/0000-0002-0306-1904 NIA [N01-AG-1-2100]; NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association); Althingi (the Icelandic Parliament); National Science Foundation Graduate Research Fellowship [DGE-0940903]; National Institutes of Health Intramural Research Program [Z01 DK071013, Z01 DK071014] This study has been funded by NIA contract N01-AG-1-2100, the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament). This work was also supported by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-0940903 and by the National Institutes of Health Intramural Research Program, grant number: Z01 DK071013 and Z01 DK071014 to RJB and KYC. Thor Aspelund is acknowledged for statistical consultation. The researchers are indebted to the participants for their willingness to participate in the study. 2 18 Elsevier science bv Amsterdam 1872-7549

PY - 2016

Y1 - 2016

N2 - Many studies have examined the hypothesis that greater participation in physical activity (PA) is associated with less brain atrophy. Here we examine, in a sub-sample (n = 352, mean age 79.1 years) of the Age, Gene/Environment Susceptibility-Reykjavik Study cohort, the association of the baseline and 5-year change in magnetic resonance imaging (MRI)-derived volumes of gray matter (GM) and white matter (WM) to active and sedentary behavior (SB) measured at the end of the 5-year period by a hip-worn accelerometer for seven consecutive days. More GM (beta = 0.11; p = 0.044) and WM (beta = 0.11; p = 0.030) at baseline was associated with more total physical activity (TPA). Also, when adjusting for baseline values, the 5-year change in GM (beta = 0.14; p = 0.0037) and WM (beta = 0.11; p = 0.030) was associated with TPA. The 5-year change in WM was associated with SB (p = 0.11; p = 0.0007). These data suggest that objectively measured PA and SB late in life are associated with current and prior cross-sectional measures of brain atrophy, and that change over time is associated with PA and SB in expected directions. (C) 2015 Elsevier B.V. All rights reserved.

AB - Many studies have examined the hypothesis that greater participation in physical activity (PA) is associated with less brain atrophy. Here we examine, in a sub-sample (n = 352, mean age 79.1 years) of the Age, Gene/Environment Susceptibility-Reykjavik Study cohort, the association of the baseline and 5-year change in magnetic resonance imaging (MRI)-derived volumes of gray matter (GM) and white matter (WM) to active and sedentary behavior (SB) measured at the end of the 5-year period by a hip-worn accelerometer for seven consecutive days. More GM (beta = 0.11; p = 0.044) and WM (beta = 0.11; p = 0.030) at baseline was associated with more total physical activity (TPA). Also, when adjusting for baseline values, the 5-year change in GM (beta = 0.14; p = 0.0037) and WM (beta = 0.11; p = 0.030) was associated with TPA. The 5-year change in WM was associated with SB (p = 0.11; p = 0.0007). These data suggest that objectively measured PA and SB late in life are associated with current and prior cross-sectional measures of brain atrophy, and that change over time is associated with PA and SB in expected directions. (C) 2015 Elsevier B.V. All rights reserved.

KW - Physical activity Sedentary behavior Brain atrophy Elderly MRI white-matter integrity cognitive decline united-states tissue volumes aging humans risk-factors exercise health atrophy population Behavioral Sciences Neurosciences & Neurology

U2 - 10.1016/j.bbr.2015.09.005

DO - 10.1016/j.bbr.2015.09.005

M3 - Journal article

C2 - 26363425

VL - 296

SP - 118

EP - 124

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

ER -