Association of Cardiovascular Disease With Respiratory Disease

Paul Carter, Jakub Lagan, Christien Fortune, Deepak L Bhatt, Jorgen Vestbo, Robert Niven, Nazia Chaudhuri, Erik B Schelbert, Rahul Potluri, Christopher Miller

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: The relationship between respiratory diseases and individual cardiovascular diseases, and the impact of cardiovascular diseases on mortality in patients with respiratory disease, are unclear. Objectives: This study sought to determine the relationship between chronic obstructive pulmonary disease (COPD), asthma and interstitial lung disease (ILD), and individual cardiovascular diseases, and evaluate the impact of individual cardiovascular diseases on all-cause mortality in respiratory conditions. Methods: The authors conducted a cohort study of all patients admitted to 7 National Health Service hospitals across the North West of England, between January 1, 2000, and March 31, 2013, with relevant respiratory diagnoses, with age-matched and sex-matched control groups. Results: A total of 31,646 COPD, 60,424 asthma, and 1,662 ILD patients were included. Control groups comprised 158,230, 302,120, and 8,310 patients, respectively (total follow-up 2,968,182 patient-years). COPD was independently associated with ischemic heart disease (IHD), heart failure (HF), atrial fibrillation, and peripheral vascular disease, all of which were associated with all-cause mortality (e.g., odds ratio for the association of COPD with HF: 2.18 [95% confidence interval (CI): 2.08 to 2.26]; hazard ratio for the contribution of HF to mortality in COPD: 1.65 [95% CI: 1.61 to 1.68]). Asthma was independently associated with IHD, and multiple cardiovascular diseases contributed to mortality (e.g., HF hazard ratio: 1.81 [95% CI: 1.75 to 1.87]). ILD was independently associated with IHD and HF, both of which were associated with mortality. Patients with lung disease were less likely to receive coronary revascularization. Conclusions: Lung disease is independently associated with cardiovascular diseases, particularly IHD and HF, which contribute significantly to all-cause mortality. However, patients with lung disease are less likely to receive coronary revascularization.

Original languageEnglish
JournalJournal of the American College of Cardiology
Volume73
Issue number17
Pages (from-to)2166-2177
ISSN0735-1097
DOIs
Publication statusPublished - 7. May 2019
Externally publishedYes

Fingerprint

Chronic Obstructive Pulmonary Disease
Interstitial Lung Diseases
Lung Diseases
Confidence Intervals
Control Groups
National Health Programs
England
Cohort Studies
Research Design
Odds Ratio

Keywords

  • asthma
  • chronic obstructive pulmonary disease
  • heart failure
  • interstitial lung fibrosis
  • ischemic heart disease

Cite this

Carter, Paul ; Lagan, Jakub ; Fortune, Christien ; Bhatt, Deepak L ; Vestbo, Jorgen ; Niven, Robert ; Chaudhuri, Nazia ; Schelbert, Erik B ; Potluri, Rahul ; Miller, Christopher. / Association of Cardiovascular Disease With Respiratory Disease. In: Journal of the American College of Cardiology. 2019 ; Vol. 73, No. 17. pp. 2166-2177.
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title = "Association of Cardiovascular Disease With Respiratory Disease",
abstract = "Background: The relationship between respiratory diseases and individual cardiovascular diseases, and the impact of cardiovascular diseases on mortality in patients with respiratory disease, are unclear. Objectives: This study sought to determine the relationship between chronic obstructive pulmonary disease (COPD), asthma and interstitial lung disease (ILD), and individual cardiovascular diseases, and evaluate the impact of individual cardiovascular diseases on all-cause mortality in respiratory conditions. Methods: The authors conducted a cohort study of all patients admitted to 7 National Health Service hospitals across the North West of England, between January 1, 2000, and March 31, 2013, with relevant respiratory diagnoses, with age-matched and sex-matched control groups. Results: A total of 31,646 COPD, 60,424 asthma, and 1,662 ILD patients were included. Control groups comprised 158,230, 302,120, and 8,310 patients, respectively (total follow-up 2,968,182 patient-years). COPD was independently associated with ischemic heart disease (IHD), heart failure (HF), atrial fibrillation, and peripheral vascular disease, all of which were associated with all-cause mortality (e.g., odds ratio for the association of COPD with HF: 2.18 [95{\%} confidence interval (CI): 2.08 to 2.26]; hazard ratio for the contribution of HF to mortality in COPD: 1.65 [95{\%} CI: 1.61 to 1.68]). Asthma was independently associated with IHD, and multiple cardiovascular diseases contributed to mortality (e.g., HF hazard ratio: 1.81 [95{\%} CI: 1.75 to 1.87]). ILD was independently associated with IHD and HF, both of which were associated with mortality. Patients with lung disease were less likely to receive coronary revascularization. Conclusions: Lung disease is independently associated with cardiovascular diseases, particularly IHD and HF, which contribute significantly to all-cause mortality. However, patients with lung disease are less likely to receive coronary revascularization.",
keywords = "Ischemic heart disease, heart failure, chronic obstructive pulmonary disease, asthma, interstitial lung fibrosis, asthma, chronic obstructive pulmonary disease, heart failure, interstitial lung fibrosis, ischemic heart disease",
author = "Paul Carter and Jakub Lagan and Christien Fortune and Bhatt, {Deepak L} and Jorgen Vestbo and Robert Niven and Nazia Chaudhuri and Schelbert, {Erik B} and Rahul Potluri and Christopher Miller",
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month = "5",
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Carter, P, Lagan, J, Fortune, C, Bhatt, DL, Vestbo, J, Niven, R, Chaudhuri, N, Schelbert, EB, Potluri, R & Miller, C 2019, 'Association of Cardiovascular Disease With Respiratory Disease', Journal of the American College of Cardiology, vol. 73, no. 17, pp. 2166-2177. https://doi.org/10.1016/j.jacc.2018.11.063

Association of Cardiovascular Disease With Respiratory Disease. / Carter, Paul; Lagan, Jakub; Fortune, Christien; Bhatt, Deepak L; Vestbo, Jorgen; Niven, Robert; Chaudhuri, Nazia; Schelbert, Erik B; Potluri, Rahul; Miller, Christopher.

In: Journal of the American College of Cardiology, Vol. 73, No. 17, 07.05.2019, p. 2166-2177.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Association of Cardiovascular Disease With Respiratory Disease

AU - Carter, Paul

AU - Lagan, Jakub

AU - Fortune, Christien

AU - Bhatt, Deepak L

AU - Vestbo, Jorgen

AU - Niven, Robert

AU - Chaudhuri, Nazia

AU - Schelbert, Erik B

AU - Potluri, Rahul

AU - Miller, Christopher

PY - 2019/5/7

Y1 - 2019/5/7

N2 - Background: The relationship between respiratory diseases and individual cardiovascular diseases, and the impact of cardiovascular diseases on mortality in patients with respiratory disease, are unclear. Objectives: This study sought to determine the relationship between chronic obstructive pulmonary disease (COPD), asthma and interstitial lung disease (ILD), and individual cardiovascular diseases, and evaluate the impact of individual cardiovascular diseases on all-cause mortality in respiratory conditions. Methods: The authors conducted a cohort study of all patients admitted to 7 National Health Service hospitals across the North West of England, between January 1, 2000, and March 31, 2013, with relevant respiratory diagnoses, with age-matched and sex-matched control groups. Results: A total of 31,646 COPD, 60,424 asthma, and 1,662 ILD patients were included. Control groups comprised 158,230, 302,120, and 8,310 patients, respectively (total follow-up 2,968,182 patient-years). COPD was independently associated with ischemic heart disease (IHD), heart failure (HF), atrial fibrillation, and peripheral vascular disease, all of which were associated with all-cause mortality (e.g., odds ratio for the association of COPD with HF: 2.18 [95% confidence interval (CI): 2.08 to 2.26]; hazard ratio for the contribution of HF to mortality in COPD: 1.65 [95% CI: 1.61 to 1.68]). Asthma was independently associated with IHD, and multiple cardiovascular diseases contributed to mortality (e.g., HF hazard ratio: 1.81 [95% CI: 1.75 to 1.87]). ILD was independently associated with IHD and HF, both of which were associated with mortality. Patients with lung disease were less likely to receive coronary revascularization. Conclusions: Lung disease is independently associated with cardiovascular diseases, particularly IHD and HF, which contribute significantly to all-cause mortality. However, patients with lung disease are less likely to receive coronary revascularization.

AB - Background: The relationship between respiratory diseases and individual cardiovascular diseases, and the impact of cardiovascular diseases on mortality in patients with respiratory disease, are unclear. Objectives: This study sought to determine the relationship between chronic obstructive pulmonary disease (COPD), asthma and interstitial lung disease (ILD), and individual cardiovascular diseases, and evaluate the impact of individual cardiovascular diseases on all-cause mortality in respiratory conditions. Methods: The authors conducted a cohort study of all patients admitted to 7 National Health Service hospitals across the North West of England, between January 1, 2000, and March 31, 2013, with relevant respiratory diagnoses, with age-matched and sex-matched control groups. Results: A total of 31,646 COPD, 60,424 asthma, and 1,662 ILD patients were included. Control groups comprised 158,230, 302,120, and 8,310 patients, respectively (total follow-up 2,968,182 patient-years). COPD was independently associated with ischemic heart disease (IHD), heart failure (HF), atrial fibrillation, and peripheral vascular disease, all of which were associated with all-cause mortality (e.g., odds ratio for the association of COPD with HF: 2.18 [95% confidence interval (CI): 2.08 to 2.26]; hazard ratio for the contribution of HF to mortality in COPD: 1.65 [95% CI: 1.61 to 1.68]). Asthma was independently associated with IHD, and multiple cardiovascular diseases contributed to mortality (e.g., HF hazard ratio: 1.81 [95% CI: 1.75 to 1.87]). ILD was independently associated with IHD and HF, both of which were associated with mortality. Patients with lung disease were less likely to receive coronary revascularization. Conclusions: Lung disease is independently associated with cardiovascular diseases, particularly IHD and HF, which contribute significantly to all-cause mortality. However, patients with lung disease are less likely to receive coronary revascularization.

KW - Ischemic heart disease

KW - heart failure

KW - chronic obstructive pulmonary disease

KW - asthma

KW - interstitial lung fibrosis

KW - asthma

KW - chronic obstructive pulmonary disease

KW - heart failure

KW - interstitial lung fibrosis

KW - ischemic heart disease

U2 - 10.1016/j.jacc.2018.11.063

DO - 10.1016/j.jacc.2018.11.063

M3 - Journal article

C2 - 30846341

VL - 73

SP - 2166

EP - 2177

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 17

ER -