TY - ABST
T1 - Association of Brain Natriuretic Peptide With Mortality in Exceptionally Long-Lived Families
AU - Kuipers, Allison
AU - Boudreau, Robert
AU - Feitosa, Mary
AU - Galvin, Angeline
AU - Thygarajan, Bharat
AU - Zmuda, Joseph
PY - 2020
Y1 - 2020
N2 - Natriuretic peptides are produced within the heart and released in response to increased chamber wall tension and heart failure (HF). N-Terminal prohormone Brain Natriuretic Peptide (NT-proBNP) is a specific natriuretic peptide commonly assayed in persons at risk for HF. In these individuals, NT-proBNP is associated with future disease prognosis and mortality. However, its association with mortality among healthy older adults remains unknown. Therefore, we determined the association of NT-proBNP with all-cause mortality over a median follow-up of 10 years in 3253 individuals free from HF at baseline in the Long Life Family Study, a study of families recruited for exceptional longevity. We performed cox proportional hazards analysis (coxme in R) for time-to event (mortality), adjusted for field center, familial relatedness, age, sex, education, smoking, alcohol, physical activity, BMI, diabetes, hypertension, and cancer. In addition, we performed secondary analyses among individuals (N=2457) within the normal NT-proBNP limits at baseline (\lt;125pg/ml aged \lt;75 years; \lt;450pg/ml aged ≥75 years). Overall, individuals were aged 32-110 years (median 67 years; 44\, had mean NT-proBNP of 318.5 pg/ml (median 91.0 pg/ml) and 1066 individuals (33\ died over the follow-up period. After adjustment, each 1 SD greater baseline NT-proBNP was associated with a 1.30-times increased hazard of mortality (95\ 1.24-1.36; P\lt;0.0001). Results were similar in individuals with normal baseline NT-proBNP (HR: 1.21; 95\ 1.11-1.32; P\lt;0.0001). These results suggest that NT-proBNP is a strong and specific biomarker for mortality in older adults independent of current health status, even in those with clinically-defined normal NT-proBNP.
AB - Natriuretic peptides are produced within the heart and released in response to increased chamber wall tension and heart failure (HF). N-Terminal prohormone Brain Natriuretic Peptide (NT-proBNP) is a specific natriuretic peptide commonly assayed in persons at risk for HF. In these individuals, NT-proBNP is associated with future disease prognosis and mortality. However, its association with mortality among healthy older adults remains unknown. Therefore, we determined the association of NT-proBNP with all-cause mortality over a median follow-up of 10 years in 3253 individuals free from HF at baseline in the Long Life Family Study, a study of families recruited for exceptional longevity. We performed cox proportional hazards analysis (coxme in R) for time-to event (mortality), adjusted for field center, familial relatedness, age, sex, education, smoking, alcohol, physical activity, BMI, diabetes, hypertension, and cancer. In addition, we performed secondary analyses among individuals (N=2457) within the normal NT-proBNP limits at baseline (\lt;125pg/ml aged \lt;75 years; \lt;450pg/ml aged ≥75 years). Overall, individuals were aged 32-110 years (median 67 years; 44\, had mean NT-proBNP of 318.5 pg/ml (median 91.0 pg/ml) and 1066 individuals (33\ died over the follow-up period. After adjustment, each 1 SD greater baseline NT-proBNP was associated with a 1.30-times increased hazard of mortality (95\ 1.24-1.36; P\lt;0.0001). Results were similar in individuals with normal baseline NT-proBNP (HR: 1.21; 95\ 1.11-1.32; P\lt;0.0001). These results suggest that NT-proBNP is a strong and specific biomarker for mortality in older adults independent of current health status, even in those with clinically-defined normal NT-proBNP.
U2 - 10.1093/geroni/igaa057.681
DO - 10.1093/geroni/igaa057.681
M3 - Conference abstract in journal
SN - 2399-5300
VL - 4
SP - 211
EP - 211
JO - Innovation in Aging
JF - Innovation in Aging
IS - Suppl. 1
T2 - GSA 2020 Annual Scientific Meeting Online
Y2 - 4 November 2020 through 7 November 2020
ER -