Association between weight loss and spontaneous changes in physical inactivity in overweight/obese individuals with knee osteoarthritis

an 8-week prospective cohort study

Cecilie Bartholdy, Robin Christensen, Lars Erik Kristensen, Henrik Gudbergsen, Henning Bliddal, Anders Overgaard, Marianne U Rasmussen, Marius Henriksen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: To describe spontaneous changes in time spent physically inactive measured continuously by accelerometry during an 8-week weight loss intervention in overweight/obese individuals with knee osteoarthritis.

METHOD: This study was designed as an observational cohort study including individuals with concomitant overweight/obesity and symptomatic knee osteoarthritis from an osteoarthritis outpatient clinic. Participants completed an 8-week dietary intervention previously shown to induce substantial weight loss. The main outcome was accelerometer-based measurement of physical inactivity for 24 hours daily during the 8-week intervention period presented as change in the average daily time spent inactive (sitting, reclined or sleeping) from one week prior to intervention to the last week of the intervention.

RESULTS: A total of 124 participants completed the dietary intervention and had valid accelerometer recordings. The mean weight loss was 12.7 kg [95% CI -13.2 to -12.1; P<.0001] after 8 weeks corresponding to a decrease in BMI of 4.3 kg/m2 [95%CI -4.5 to -4.2; P<.0001]. Significant improvements in osteoarthritis symptoms (assessed by the Knee Injury and Osteoarthritis Outcome Score) was found across all subscales; for KOOS pain an improvement of 12.8 points [95% CI, 10.6 to 15.0; P<.0001] was observed. No statistically significant change occurred in the average daily time spent inactive from baseline to follow-up (mean change: 8.8 minutes/day [95% CI, -12.1 to 29.7]; P=0.41).

CONCLUSION: Physical inactivity remains stable despite a clinically significant weight loss and improvements in knee osteoarthritis symptoms. Change in inactivity does not seem to occur spontaneously, suggesting that focused efforts to reduce inactive behaviors are needed. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalArthritis Care & Research
ISSN2151-464X
DOIs
Publication statusE-pub ahead of print - 1. Mar 2019

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Knee Osteoarthritis
Cohort Studies
Prospective Studies
Knee Injuries
Ambulatory Care Facilities

Cite this

Bartholdy, Cecilie ; Christensen, Robin ; Kristensen, Lars Erik ; Gudbergsen, Henrik ; Bliddal, Henning ; Overgaard, Anders ; Rasmussen, Marianne U ; Henriksen, Marius. / Association between weight loss and spontaneous changes in physical inactivity in overweight/obese individuals with knee osteoarthritis : an 8-week prospective cohort study. In: Arthritis Care & Research. 2019.
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title = "Association between weight loss and spontaneous changes in physical inactivity in overweight/obese individuals with knee osteoarthritis: an 8-week prospective cohort study",
abstract = "OBJECTIVE: To describe spontaneous changes in time spent physically inactive measured continuously by accelerometry during an 8-week weight loss intervention in overweight/obese individuals with knee osteoarthritis.METHOD: This study was designed as an observational cohort study including individuals with concomitant overweight/obesity and symptomatic knee osteoarthritis from an osteoarthritis outpatient clinic. Participants completed an 8-week dietary intervention previously shown to induce substantial weight loss. The main outcome was accelerometer-based measurement of physical inactivity for 24 hours daily during the 8-week intervention period presented as change in the average daily time spent inactive (sitting, reclined or sleeping) from one week prior to intervention to the last week of the intervention.RESULTS: A total of 124 participants completed the dietary intervention and had valid accelerometer recordings. The mean weight loss was 12.7 kg [95{\%} CI -13.2 to -12.1; P<.0001] after 8 weeks corresponding to a decrease in BMI of 4.3 kg/m2 [95{\%}CI -4.5 to -4.2; P<.0001]. Significant improvements in osteoarthritis symptoms (assessed by the Knee Injury and Osteoarthritis Outcome Score) was found across all subscales; for KOOS pain an improvement of 12.8 points [95{\%} CI, 10.6 to 15.0; P<.0001] was observed. No statistically significant change occurred in the average daily time spent inactive from baseline to follow-up (mean change: 8.8 minutes/day [95{\%} CI, -12.1 to 29.7]; P=0.41).CONCLUSION: Physical inactivity remains stable despite a clinically significant weight loss and improvements in knee osteoarthritis symptoms. Change in inactivity does not seem to occur spontaneously, suggesting that focused efforts to reduce inactive behaviors are needed. This article is protected by copyright. All rights reserved.",
author = "Cecilie Bartholdy and Robin Christensen and Kristensen, {Lars Erik} and Henrik Gudbergsen and Henning Bliddal and Anders Overgaard and Rasmussen, {Marianne U} and Marius Henriksen",
note = "This article is protected by copyright. All rights reserved.",
year = "2019",
month = "3",
day = "1",
doi = "10.1002/acr.23868",
language = "English",
journal = "Arthritis Care & Research",
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Association between weight loss and spontaneous changes in physical inactivity in overweight/obese individuals with knee osteoarthritis : an 8-week prospective cohort study. / Bartholdy, Cecilie; Christensen, Robin; Kristensen, Lars Erik; Gudbergsen, Henrik; Bliddal, Henning; Overgaard, Anders; Rasmussen, Marianne U; Henriksen, Marius.

In: Arthritis Care & Research, 01.03.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Association between weight loss and spontaneous changes in physical inactivity in overweight/obese individuals with knee osteoarthritis

T2 - an 8-week prospective cohort study

AU - Bartholdy, Cecilie

AU - Christensen, Robin

AU - Kristensen, Lars Erik

AU - Gudbergsen, Henrik

AU - Bliddal, Henning

AU - Overgaard, Anders

AU - Rasmussen, Marianne U

AU - Henriksen, Marius

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - OBJECTIVE: To describe spontaneous changes in time spent physically inactive measured continuously by accelerometry during an 8-week weight loss intervention in overweight/obese individuals with knee osteoarthritis.METHOD: This study was designed as an observational cohort study including individuals with concomitant overweight/obesity and symptomatic knee osteoarthritis from an osteoarthritis outpatient clinic. Participants completed an 8-week dietary intervention previously shown to induce substantial weight loss. The main outcome was accelerometer-based measurement of physical inactivity for 24 hours daily during the 8-week intervention period presented as change in the average daily time spent inactive (sitting, reclined or sleeping) from one week prior to intervention to the last week of the intervention.RESULTS: A total of 124 participants completed the dietary intervention and had valid accelerometer recordings. The mean weight loss was 12.7 kg [95% CI -13.2 to -12.1; P<.0001] after 8 weeks corresponding to a decrease in BMI of 4.3 kg/m2 [95%CI -4.5 to -4.2; P<.0001]. Significant improvements in osteoarthritis symptoms (assessed by the Knee Injury and Osteoarthritis Outcome Score) was found across all subscales; for KOOS pain an improvement of 12.8 points [95% CI, 10.6 to 15.0; P<.0001] was observed. No statistically significant change occurred in the average daily time spent inactive from baseline to follow-up (mean change: 8.8 minutes/day [95% CI, -12.1 to 29.7]; P=0.41).CONCLUSION: Physical inactivity remains stable despite a clinically significant weight loss and improvements in knee osteoarthritis symptoms. Change in inactivity does not seem to occur spontaneously, suggesting that focused efforts to reduce inactive behaviors are needed. This article is protected by copyright. All rights reserved.

AB - OBJECTIVE: To describe spontaneous changes in time spent physically inactive measured continuously by accelerometry during an 8-week weight loss intervention in overweight/obese individuals with knee osteoarthritis.METHOD: This study was designed as an observational cohort study including individuals with concomitant overweight/obesity and symptomatic knee osteoarthritis from an osteoarthritis outpatient clinic. Participants completed an 8-week dietary intervention previously shown to induce substantial weight loss. The main outcome was accelerometer-based measurement of physical inactivity for 24 hours daily during the 8-week intervention period presented as change in the average daily time spent inactive (sitting, reclined or sleeping) from one week prior to intervention to the last week of the intervention.RESULTS: A total of 124 participants completed the dietary intervention and had valid accelerometer recordings. The mean weight loss was 12.7 kg [95% CI -13.2 to -12.1; P<.0001] after 8 weeks corresponding to a decrease in BMI of 4.3 kg/m2 [95%CI -4.5 to -4.2; P<.0001]. Significant improvements in osteoarthritis symptoms (assessed by the Knee Injury and Osteoarthritis Outcome Score) was found across all subscales; for KOOS pain an improvement of 12.8 points [95% CI, 10.6 to 15.0; P<.0001] was observed. No statistically significant change occurred in the average daily time spent inactive from baseline to follow-up (mean change: 8.8 minutes/day [95% CI, -12.1 to 29.7]; P=0.41).CONCLUSION: Physical inactivity remains stable despite a clinically significant weight loss and improvements in knee osteoarthritis symptoms. Change in inactivity does not seem to occur spontaneously, suggesting that focused efforts to reduce inactive behaviors are needed. This article is protected by copyright. All rights reserved.

U2 - 10.1002/acr.23868

DO - 10.1002/acr.23868

M3 - Journal article

JO - Arthritis Care & Research

JF - Arthritis Care & Research

SN - 2151-464X

ER -