Association between use of cannabis in adolescence and weight change into midlife

Lexie Zhiyan Jin, Anna Rangan, Jesper Mehlsen, Lars Bo Andersen, Sofus C. Larsen, Berit L. Heitmann

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Abstract

Cannabis use has been found to stimulate appetite and potentially promote weight gain via activation of the endocannabinoid system. Despite the fact that the onset of cannabis use is typically during adolescence, the association between adolescence cannabis use and longterm change in body weight is generally unknown. This study aims to examine the association between adolescence cannabis use and weight change to midlife, while accounting for the use of other substances. The study applied 20 to 22 years of follow-up data on 712 Danish adolescents aged between 15 and 19 years at baseline. Self-reported height and weight, cannabis, cigarette and alcohol use, socioeconomic status (SES) and physical activity levels were assessed in baseline surveys conducted in 1983 and 1985. The follow-up survey was conducted in 2005. In total 19.1% (n = 136) of adolescents reported having used/using cannabis. Weight gain between adolescence and midlife was not related to cannabis exposure during adolescence in either crude or adjusted models, and associations were not modified by baseline alcohol intake or smoking. However, cannabis use was significantly associated with cigarette smoking (p<0.001) and alcohol intake (p<0.001) and inversely associated with physical activity levels (p = 0.04). In conclusion, this study does not provide evidence of an association between adolescence cannabis use and weight change from adolescence to midlife.

Original languageEnglish
Article number0168897
JournalPLOS ONE
Volume12
Issue number1
Number of pages11
ISSN1932-6203
DOIs
Publication statusPublished - 2017

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adolescence
Cannabis
Weights and Measures
Alcohols
Association reactions
Tobacco Products
physical activity
Weight Gain
Smoking
weight gain
Exercise
Endocannabinoids
smoking (habit)
cigarettes
body weight changes
socioeconomic status
appetite
alcohols
Chemical activation

Cite this

Jin, Lexie Zhiyan ; Rangan, Anna ; Mehlsen, Jesper ; Andersen, Lars Bo ; Larsen, Sofus C. ; Heitmann, Berit L. / Association between use of cannabis in adolescence and weight change into midlife. In: PLOS ONE. 2017 ; Vol. 12, No. 1.
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abstract = "Cannabis use has been found to stimulate appetite and potentially promote weight gain via activation of the endocannabinoid system. Despite the fact that the onset of cannabis use is typically during adolescence, the association between adolescence cannabis use and longterm change in body weight is generally unknown. This study aims to examine the association between adolescence cannabis use and weight change to midlife, while accounting for the use of other substances. The study applied 20 to 22 years of follow-up data on 712 Danish adolescents aged between 15 and 19 years at baseline. Self-reported height and weight, cannabis, cigarette and alcohol use, socioeconomic status (SES) and physical activity levels were assessed in baseline surveys conducted in 1983 and 1985. The follow-up survey was conducted in 2005. In total 19.1{\%} (n = 136) of adolescents reported having used/using cannabis. Weight gain between adolescence and midlife was not related to cannabis exposure during adolescence in either crude or adjusted models, and associations were not modified by baseline alcohol intake or smoking. However, cannabis use was significantly associated with cigarette smoking (p<0.001) and alcohol intake (p<0.001) and inversely associated with physical activity levels (p = 0.04). In conclusion, this study does not provide evidence of an association between adolescence cannabis use and weight change from adolescence to midlife.",
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Association between use of cannabis in adolescence and weight change into midlife. / Jin, Lexie Zhiyan; Rangan, Anna; Mehlsen, Jesper; Andersen, Lars Bo; Larsen, Sofus C.; Heitmann, Berit L.

In: PLOS ONE, Vol. 12, No. 1, 0168897, 2017.

Research output: Contribution to journalJournal articleResearchpeer-review

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