Association between plasma leptin and blood pressure in two population-based samples of children and adolescents

Anders Grøntved, Jostein Steene-Johannessen, Iben Kynde, Paul W Franks, Jørn Wulf Helge, Karsten Froberg, Sigmund A Anderssen, Lars Bo Andersen

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Abstract

OBJECTIVES: In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of leptin in the association between body mass index and blood pressure. METHODS: To examine these aims we used a cross-sectional random sample of children and adolescents from Denmark and Norway (n = 1993) who had measures of leptin, anthropometry, blood pressure and other personal and biological risk factors for raised blood pressure available. RESULTS: Both body mass index and leptin were positively associated with blood pressure (P <0.001). The association with leptin was stronger in pre- and early-pubertal children compared to late- and post-pubertal adolescents (P <0.01 for interaction). The association between leptin and blood pressure was almost completely mediated by body mass index, whereas the association between body mass index and blood pressure was modestly mediated by leptin. CONCLUSION: Leptin was strongly associated with blood pressure, a relationship that to a large extent was mediated by body mass index. Conversely, the association between body mass index and blood pressure was only modestly mediated by leptin. This indicates that the influence of adiposity on blood pressure is also driven by other biological risk factors beyond leptin. Such factors could include insulin, glucose, and triglycerides although residual confounding also could account for the observed relationships.
Original languageEnglish
JournalJournal of Hypertension
Volume29
Issue number6
Pages (from-to)1093-1100
Number of pages8
ISSN0263-6352
DOIs
Publication statusPublished - 1. Jun 2011

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Leptin
Body Mass Index
Population
Adiposity
Denmark
Norway
Insulin

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Grøntved, Anders ; Steene-Johannessen, Jostein ; Kynde, Iben ; Franks, Paul W ; Helge, Jørn Wulf ; Froberg, Karsten ; Anderssen, Sigmund A ; Andersen, Lars Bo. / Association between plasma leptin and blood pressure in two population-based samples of children and adolescents. In: Journal of Hypertension. 2011 ; Vol. 29, No. 6. pp. 1093-1100.
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abstract = "OBJECTIVES: In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of leptin in the association between body mass index and blood pressure. METHODS: To examine these aims we used a cross-sectional random sample of children and adolescents from Denmark and Norway (n = 1993) who had measures of leptin, anthropometry, blood pressure and other personal and biological risk factors for raised blood pressure available. RESULTS: Both body mass index and leptin were positively associated with blood pressure (P <0.001). The association with leptin was stronger in pre- and early-pubertal children compared to late- and post-pubertal adolescents (P <0.01 for interaction). The association between leptin and blood pressure was almost completely mediated by body mass index, whereas the association between body mass index and blood pressure was modestly mediated by leptin. CONCLUSION: Leptin was strongly associated with blood pressure, a relationship that to a large extent was mediated by body mass index. Conversely, the association between body mass index and blood pressure was only modestly mediated by leptin. This indicates that the influence of adiposity on blood pressure is also driven by other biological risk factors beyond leptin. Such factors could include insulin, glucose, and triglycerides although residual confounding also could account for the observed relationships.",
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Association between plasma leptin and blood pressure in two population-based samples of children and adolescents. / Grøntved, Anders; Steene-Johannessen, Jostein; Kynde, Iben; Franks, Paul W; Helge, Jørn Wulf; Froberg, Karsten; Anderssen, Sigmund A; Andersen, Lars Bo.

In: Journal of Hypertension, Vol. 29, No. 6, 01.06.2011, p. 1093-1100.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Association between plasma leptin and blood pressure in two population-based samples of children and adolescents

AU - Grøntved, Anders

AU - Steene-Johannessen, Jostein

AU - Kynde, Iben

AU - Franks, Paul W

AU - Helge, Jørn Wulf

AU - Froberg, Karsten

AU - Anderssen, Sigmund A

AU - Andersen, Lars Bo

PY - 2011/6/1

Y1 - 2011/6/1

N2 - OBJECTIVES: In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of leptin in the association between body mass index and blood pressure. METHODS: To examine these aims we used a cross-sectional random sample of children and adolescents from Denmark and Norway (n = 1993) who had measures of leptin, anthropometry, blood pressure and other personal and biological risk factors for raised blood pressure available. RESULTS: Both body mass index and leptin were positively associated with blood pressure (P <0.001). The association with leptin was stronger in pre- and early-pubertal children compared to late- and post-pubertal adolescents (P <0.01 for interaction). The association between leptin and blood pressure was almost completely mediated by body mass index, whereas the association between body mass index and blood pressure was modestly mediated by leptin. CONCLUSION: Leptin was strongly associated with blood pressure, a relationship that to a large extent was mediated by body mass index. Conversely, the association between body mass index and blood pressure was only modestly mediated by leptin. This indicates that the influence of adiposity on blood pressure is also driven by other biological risk factors beyond leptin. Such factors could include insulin, glucose, and triglycerides although residual confounding also could account for the observed relationships.

AB - OBJECTIVES: In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of leptin in the association between body mass index and blood pressure. METHODS: To examine these aims we used a cross-sectional random sample of children and adolescents from Denmark and Norway (n = 1993) who had measures of leptin, anthropometry, blood pressure and other personal and biological risk factors for raised blood pressure available. RESULTS: Both body mass index and leptin were positively associated with blood pressure (P <0.001). The association with leptin was stronger in pre- and early-pubertal children compared to late- and post-pubertal adolescents (P <0.01 for interaction). The association between leptin and blood pressure was almost completely mediated by body mass index, whereas the association between body mass index and blood pressure was modestly mediated by leptin. CONCLUSION: Leptin was strongly associated with blood pressure, a relationship that to a large extent was mediated by body mass index. Conversely, the association between body mass index and blood pressure was only modestly mediated by leptin. This indicates that the influence of adiposity on blood pressure is also driven by other biological risk factors beyond leptin. Such factors could include insulin, glucose, and triglycerides although residual confounding also could account for the observed relationships.

U2 - 10.1097/HJH.0b013e328346d787

DO - 10.1097/HJH.0b013e328346d787

M3 - Journal article

C2 - 21505347

VL - 29

SP - 1093

EP - 1100

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 6

ER -