Association between intake of dietary protein and 3-year-change in body growth among normal and overweight 6-year-old boys and girls (CoSCIS)

Anneke Jah van Vught, Berit Lilienthal Heitmann, Arie G Nieuwenhuizen, Margriet Ab Veldhorst, Lars Bo Andersen, Henriette Hasselstrom, Robert-Jan M Brummer, Margriet S Westerterp-Plantenga

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: Growth hormone (GH) affects linear growth and body composition, by increasing the secretion of insulin-like growth factor-I (IGF-I), muscle protein synthesis and lipolysis. The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion. The present paper aimed to investigate associations between PROT intake as well as intake of the specific amino acids ARG and LYS, and subsequent 3-year-change in linear growth and body composition among 6-year-old children. DESIGN: Children's data were collected from Copenhagen (Denmark), during 2001-2002, and again 3 years later. Boys and girls were separated into normal weight and overweight, based on BMI quintiles. Fat-free mass index (FFMI) and fat mass index (FMI) were calculated. Associations between change (Delta) in height, FMI and FFMI, respectively, and habitual PROT intake as well as ARG and LYS were analysed by multiple linear regressions, adjusted for baseline height, FMI or FFMI and energy intake, age, physical activity and socio-economic status. SETTING: Eighteen schools in two suburban communities in the Copenhagen (Denmark) area participated in the study. SUBJECTS: In all, 223 children's data were collected for the present study. RESULTS: High ARG intake was associated with linear growth (beta = 1.09 (se 0.54), P = 0.05) among girls. Furthermore, in girls, DeltaFMI had a stronger inverse association with high ARG intake, if it was combined with high LYS intake, instead of low LYS intake (P = 0.03). No associations were found in boys.ConclusionIn prepubertal girls, linear growth may be influenced by habitual ARG intake and body fat gain may be relatively prevented over time by the intake of the amino acids ARG and LYS.
Original languageEnglish
JournalPublic Health Nutrition
Volume13
Pages (from-to)647-653
Number of pages6
ISSN1368-9800
DOIs
Publication statusPublished - 2010

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Dietary Proteins
Lysine
Fats
Growth
Denmark
Insulin-Like Growth Factor I
Amino Acids
Proteins
Muscle Proteins
Adipose Tissue
Linear Models
Exercise
Weights and Measures

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van Vught, A. J., Heitmann, B. L., Nieuwenhuizen, A. G., Veldhorst, M. A., Andersen, L. B., Hasselstrom, H., ... Westerterp-Plantenga, M. S. (2010). Association between intake of dietary protein and 3-year-change in body growth among normal and overweight 6-year-old boys and girls (CoSCIS). Public Health Nutrition, 13, 647-653. https://doi.org/10.1017/S1368980009991510
van Vught, Anneke Jah ; Heitmann, Berit Lilienthal ; Nieuwenhuizen, Arie G ; Veldhorst, Margriet Ab ; Andersen, Lars Bo ; Hasselstrom, Henriette ; Brummer, Robert-Jan M ; Westerterp-Plantenga, Margriet S. / Association between intake of dietary protein and 3-year-change in body growth among normal and overweight 6-year-old boys and girls (CoSCIS). In: Public Health Nutrition. 2010 ; Vol. 13. pp. 647-653.
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title = "Association between intake of dietary protein and 3-year-change in body growth among normal and overweight 6-year-old boys and girls (CoSCIS)",
abstract = "OBJECTIVE: Growth hormone (GH) affects linear growth and body composition, by increasing the secretion of insulin-like growth factor-I (IGF-I), muscle protein synthesis and lipolysis. The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion. The present paper aimed to investigate associations between PROT intake as well as intake of the specific amino acids ARG and LYS, and subsequent 3-year-change in linear growth and body composition among 6-year-old children. DESIGN: Children's data were collected from Copenhagen (Denmark), during 2001-2002, and again 3 years later. Boys and girls were separated into normal weight and overweight, based on BMI quintiles. Fat-free mass index (FFMI) and fat mass index (FMI) were calculated. Associations between change (Delta) in height, FMI and FFMI, respectively, and habitual PROT intake as well as ARG and LYS were analysed by multiple linear regressions, adjusted for baseline height, FMI or FFMI and energy intake, age, physical activity and socio-economic status. SETTING: Eighteen schools in two suburban communities in the Copenhagen (Denmark) area participated in the study. SUBJECTS: In all, 223 children's data were collected for the present study. RESULTS: High ARG intake was associated with linear growth (beta = 1.09 (se 0.54), P = 0.05) among girls. Furthermore, in girls, DeltaFMI had a stronger inverse association with high ARG intake, if it was combined with high LYS intake, instead of low LYS intake (P = 0.03). No associations were found in boys.ConclusionIn prepubertal girls, linear growth may be influenced by habitual ARG intake and body fat gain may be relatively prevented over time by the intake of the amino acids ARG and LYS.",
author = "{van Vught}, {Anneke Jah} and Heitmann, {Berit Lilienthal} and Nieuwenhuizen, {Arie G} and Veldhorst, {Margriet Ab} and Andersen, {Lars Bo} and Henriette Hasselstrom and Brummer, {Robert-Jan M} and Westerterp-Plantenga, {Margriet S}",
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language = "English",
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van Vught, AJ, Heitmann, BL, Nieuwenhuizen, AG, Veldhorst, MA, Andersen, LB, Hasselstrom, H, Brummer, R-JM & Westerterp-Plantenga, MS 2010, 'Association between intake of dietary protein and 3-year-change in body growth among normal and overweight 6-year-old boys and girls (CoSCIS)', Public Health Nutrition, vol. 13, pp. 647-653. https://doi.org/10.1017/S1368980009991510

Association between intake of dietary protein and 3-year-change in body growth among normal and overweight 6-year-old boys and girls (CoSCIS). / van Vught, Anneke Jah; Heitmann, Berit Lilienthal; Nieuwenhuizen, Arie G; Veldhorst, Margriet Ab; Andersen, Lars Bo; Hasselstrom, Henriette; Brummer, Robert-Jan M; Westerterp-Plantenga, Margriet S.

In: Public Health Nutrition, Vol. 13, 2010, p. 647-653.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Association between intake of dietary protein and 3-year-change in body growth among normal and overweight 6-year-old boys and girls (CoSCIS)

AU - van Vught, Anneke Jah

AU - Heitmann, Berit Lilienthal

AU - Nieuwenhuizen, Arie G

AU - Veldhorst, Margriet Ab

AU - Andersen, Lars Bo

AU - Hasselstrom, Henriette

AU - Brummer, Robert-Jan M

AU - Westerterp-Plantenga, Margriet S

PY - 2010

Y1 - 2010

N2 - OBJECTIVE: Growth hormone (GH) affects linear growth and body composition, by increasing the secretion of insulin-like growth factor-I (IGF-I), muscle protein synthesis and lipolysis. The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion. The present paper aimed to investigate associations between PROT intake as well as intake of the specific amino acids ARG and LYS, and subsequent 3-year-change in linear growth and body composition among 6-year-old children. DESIGN: Children's data were collected from Copenhagen (Denmark), during 2001-2002, and again 3 years later. Boys and girls were separated into normal weight and overweight, based on BMI quintiles. Fat-free mass index (FFMI) and fat mass index (FMI) were calculated. Associations between change (Delta) in height, FMI and FFMI, respectively, and habitual PROT intake as well as ARG and LYS were analysed by multiple linear regressions, adjusted for baseline height, FMI or FFMI and energy intake, age, physical activity and socio-economic status. SETTING: Eighteen schools in two suburban communities in the Copenhagen (Denmark) area participated in the study. SUBJECTS: In all, 223 children's data were collected for the present study. RESULTS: High ARG intake was associated with linear growth (beta = 1.09 (se 0.54), P = 0.05) among girls. Furthermore, in girls, DeltaFMI had a stronger inverse association with high ARG intake, if it was combined with high LYS intake, instead of low LYS intake (P = 0.03). No associations were found in boys.ConclusionIn prepubertal girls, linear growth may be influenced by habitual ARG intake and body fat gain may be relatively prevented over time by the intake of the amino acids ARG and LYS.

AB - OBJECTIVE: Growth hormone (GH) affects linear growth and body composition, by increasing the secretion of insulin-like growth factor-I (IGF-I), muscle protein synthesis and lipolysis. The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion. The present paper aimed to investigate associations between PROT intake as well as intake of the specific amino acids ARG and LYS, and subsequent 3-year-change in linear growth and body composition among 6-year-old children. DESIGN: Children's data were collected from Copenhagen (Denmark), during 2001-2002, and again 3 years later. Boys and girls were separated into normal weight and overweight, based on BMI quintiles. Fat-free mass index (FFMI) and fat mass index (FMI) were calculated. Associations between change (Delta) in height, FMI and FFMI, respectively, and habitual PROT intake as well as ARG and LYS were analysed by multiple linear regressions, adjusted for baseline height, FMI or FFMI and energy intake, age, physical activity and socio-economic status. SETTING: Eighteen schools in two suburban communities in the Copenhagen (Denmark) area participated in the study. SUBJECTS: In all, 223 children's data were collected for the present study. RESULTS: High ARG intake was associated with linear growth (beta = 1.09 (se 0.54), P = 0.05) among girls. Furthermore, in girls, DeltaFMI had a stronger inverse association with high ARG intake, if it was combined with high LYS intake, instead of low LYS intake (P = 0.03). No associations were found in boys.ConclusionIn prepubertal girls, linear growth may be influenced by habitual ARG intake and body fat gain may be relatively prevented over time by the intake of the amino acids ARG and LYS.

U2 - 10.1017/S1368980009991510

DO - 10.1017/S1368980009991510

M3 - Journal article

C2 - 19758483

VL - 13

SP - 647

EP - 653

JO - Public Health Nutrition

JF - Public Health Nutrition

SN - 1368-9800

ER -