Association between high-sensitive troponin I and coronary artery calcification in a Danish general population

Fredrik Olson, Jonathan Engborg, Mette H. Grønhøj, Niels P. Sand, Jess Lambrechtsen, Flemming Hald Steffensen, Mads Nybo, Oke Gerke, Hans Mickley, Axel C. P. Diederichsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: High-sensitive troponin I (hs-TnI) is an individual predictor of future cardiovascular disease (CVD). However, the relationship between hs-TnI and coronary artery calcification (CAC) as determined by computed tomography (CT) has not previously been investigated in a general population. Methods: 1173 randomized, middle-aged subjects without known CVD underwent a non-contrast cardiac-CT scan for CAC determination. Hs-TnI was detected using ARCHITECT STAT High Sensitive Troponin-I immunoassay. Total 10-year cardiovascular mortality risk was estimated using HeartScore. The relationship between hs-TnI and CAC was assessed using logistic regression analyses and receiver operating characteristic curves (ROC). Results: Concentrations of hs-TnI above the limit of detection were measured in 89.3% of all subjects. Presence of CAC (Agatston score >0) was detected in 29% in the lowest hs-TnI quartile compared with 55% in the highest, with a stepwise increase over the quartiles. In fully adjusted regression models with dichotomous CAC outcomes, hs-TnI was able to predict presence of CAC (OR: 1.25, 95% CI: 1.03-1.51, p = 0.025) and an Agatston score >100 (OR: 1.36, 95% CI: 1.08-1.71, p = 0.009). Subjects in the fourth hs-TnI quartile had an increased risk for presence of CAC (OR: 1.56, 95% CI: 1.06-2.26, p = 0.024) and for an Agatston score >100 (OR: 1.82, 95% CI: 1.04-3.18, p = 0.035), when compared with the first quartile. Addition of hs-TnI to HeartScore improved the ROC AUC from 0.671 to 0.695 (p < 0.0001). Conclusion: Hs-TnI was associated with CAC in a Danish middle-aged population without previously known CVD. This is a step towards understanding hs-TnI as a risk marker for CVD.

Original languageEnglish
JournalAtherosclerosis
Volume245
Pages (from-to)88-93
ISSN0021-9150
DOIs
Publication statusPublished - Feb 2016

Keywords

  • Agatston score
  • Cardiovascular risk
  • Coronary artery calcification
  • Coronary artery disease
  • DanRisk
  • General population
  • High-sensitive troponin I

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