Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy: 7 receptor alpha-chain and inhalation allergy

Z Shamim, K Müller, A Svejgaard, L K Poulsen, Uffe Bødtger, L P Ryder

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Ralpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Ralpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.

Original languageEnglish
JournalInternational Journal of Immunogenetics (Print Edition)
Volume34
Issue number3
Pages (from-to)149-151
ISSN1744-3121
DOIs
Publication statusPublished - 2007
Externally publishedYes

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Keywords

  • Allergy
  • Receptors, Interleukin-7
  • Rhinitis, Allergic, Seasonal
  • In vitro

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