Association between birth weight and objectively measured sedentary time is mediated by central adiposity: data in 10,793 youth from the International Children's Accelerometry Database

Maria Hildebrand, Elin Kolle, Bjørge H Hansen, Paul J Collings, Katrien Wijndaele, Katarzyna Kordas, Ashley R Cooper, Lauren B Sherar, Lars Bo Andersen, Luis B Sardinha, Susi Kriemler, Pedro Hallal, Esther van Sluijs, Ulf Ekelund

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Abstract

BACKGROUND: Birth weight is an early correlate of disease later in life, and animal studies suggest that low birth weight is associated with reduced activity and increased sedentary time. Whether birth weight predicts later sedentary time in humans is uncertain.

OBJECTIVES: We examined the relation between birth weight and sedentary time in youth and examined whether this association was mediated by central adiposity.

DESIGN: We used pooled cross-sectional data from 8 observational studies conducted between 1997 and 2007 that consisted of 10,793 youth (boys: 47%) aged 6-18 y from the International Children's Accelerometry Database. Birth weight was measured in hospitals or maternally reported, sedentary time was assessed by using accelerometry (<100 counts/min), and abdominal adiposity (waist circumference) was measured according to WHO procedures. A mediation analysis with bootstrapping was used to analyze data.

RESULTS: The mean (±SD) time spent sedentary was 370 ± 91 min/d. Birth weight was positively associated with sedentary time (B = 4.04, P = 0.006) and waist circumference (B = 1.59, P < 0.001), whereas waist circumference was positively associated with sedentary time (B = 0.82, P < 0.001). Results of the mediation analysis showed a significant indirect effect of birth weight on sedentary time through waist circumference (B: 1.30; 95% bias-corrected CI: 0.94, 1.72), and when waist circumference was controlled for, the effect of birth weight on sedentary time was attenuated by 32% (B = 2.74, P = 0.06).

CONCLUSION: The association between birth weight and sedentary time appears partially mediated by central adiposity, suggesting that both birth weight and abdominal adiposity may be correlates of sedentary time in youth.

Original languageEnglish
JournalThe American Journal of Clinical Nutrition
Volume101
Issue number5
Pages (from-to)983-990
Number of pages8
ISSN0002-9165
DOIs
Publication statusPublished - May 2015

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Low Birth Weight Infant

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First published ahead of print April 1, 2015

Cite this

Hildebrand, Maria ; Kolle, Elin ; Hansen, Bjørge H ; Collings, Paul J ; Wijndaele, Katrien ; Kordas, Katarzyna ; Cooper, Ashley R ; Sherar, Lauren B ; Andersen, Lars Bo ; Sardinha, Luis B ; Kriemler, Susi ; Hallal, Pedro ; van Sluijs, Esther ; Ekelund, Ulf. / Association between birth weight and objectively measured sedentary time is mediated by central adiposity : data in 10,793 youth from the International Children's Accelerometry Database. In: The American Journal of Clinical Nutrition. 2015 ; Vol. 101, No. 5. pp. 983-990.
@article{85b334f2c85f438a9ed6cdbfdfd08aca,
title = "Association between birth weight and objectively measured sedentary time is mediated by central adiposity: data in 10,793 youth from the International Children's Accelerometry Database",
abstract = "BACKGROUND: Birth weight is an early correlate of disease later in life, and animal studies suggest that low birth weight is associated with reduced activity and increased sedentary time. Whether birth weight predicts later sedentary time in humans is uncertain.OBJECTIVES: We examined the relation between birth weight and sedentary time in youth and examined whether this association was mediated by central adiposity.DESIGN: We used pooled cross-sectional data from 8 observational studies conducted between 1997 and 2007 that consisted of 10,793 youth (boys: 47{\%}) aged 6-18 y from the International Children's Accelerometry Database. Birth weight was measured in hospitals or maternally reported, sedentary time was assessed by using accelerometry (<100 counts/min), and abdominal adiposity (waist circumference) was measured according to WHO procedures. A mediation analysis with bootstrapping was used to analyze data.RESULTS: The mean (±SD) time spent sedentary was 370 ± 91 min/d. Birth weight was positively associated with sedentary time (B = 4.04, P = 0.006) and waist circumference (B = 1.59, P < 0.001), whereas waist circumference was positively associated with sedentary time (B = 0.82, P < 0.001). Results of the mediation analysis showed a significant indirect effect of birth weight on sedentary time through waist circumference (B: 1.30; 95{\%} bias-corrected CI: 0.94, 1.72), and when waist circumference was controlled for, the effect of birth weight on sedentary time was attenuated by 32{\%} (B = 2.74, P = 0.06).CONCLUSION: The association between birth weight and sedentary time appears partially mediated by central adiposity, suggesting that both birth weight and abdominal adiposity may be correlates of sedentary time in youth.",
author = "Maria Hildebrand and Elin Kolle and Hansen, {Bj{\o}rge H} and Collings, {Paul J} and Katrien Wijndaele and Katarzyna Kordas and Cooper, {Ashley R} and Sherar, {Lauren B} and Andersen, {Lars Bo} and Sardinha, {Luis B} and Susi Kriemler and Pedro Hallal and {van Sluijs}, Esther and Ulf Ekelund",
note = "First published ahead of print April 1, 2015",
year = "2015",
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doi = "10.3945/ajcn.114.103648",
language = "English",
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Hildebrand, M, Kolle, E, Hansen, BH, Collings, PJ, Wijndaele, K, Kordas, K, Cooper, AR, Sherar, LB, Andersen, LB, Sardinha, LB, Kriemler, S, Hallal, P, van Sluijs, E & Ekelund, U 2015, 'Association between birth weight and objectively measured sedentary time is mediated by central adiposity: data in 10,793 youth from the International Children's Accelerometry Database', The American Journal of Clinical Nutrition, vol. 101, no. 5, pp. 983-990. https://doi.org/10.3945/ajcn.114.103648

Association between birth weight and objectively measured sedentary time is mediated by central adiposity : data in 10,793 youth from the International Children's Accelerometry Database. / Hildebrand, Maria; Kolle, Elin; Hansen, Bjørge H; Collings, Paul J; Wijndaele, Katrien; Kordas, Katarzyna; Cooper, Ashley R; Sherar, Lauren B; Andersen, Lars Bo; Sardinha, Luis B; Kriemler, Susi; Hallal, Pedro; van Sluijs, Esther; Ekelund, Ulf.

In: The American Journal of Clinical Nutrition, Vol. 101, No. 5, 05.2015, p. 983-990.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Association between birth weight and objectively measured sedentary time is mediated by central adiposity

T2 - data in 10,793 youth from the International Children's Accelerometry Database

AU - Hildebrand, Maria

AU - Kolle, Elin

AU - Hansen, Bjørge H

AU - Collings, Paul J

AU - Wijndaele, Katrien

AU - Kordas, Katarzyna

AU - Cooper, Ashley R

AU - Sherar, Lauren B

AU - Andersen, Lars Bo

AU - Sardinha, Luis B

AU - Kriemler, Susi

AU - Hallal, Pedro

AU - van Sluijs, Esther

AU - Ekelund, Ulf

N1 - First published ahead of print April 1, 2015

PY - 2015/5

Y1 - 2015/5

N2 - BACKGROUND: Birth weight is an early correlate of disease later in life, and animal studies suggest that low birth weight is associated with reduced activity and increased sedentary time. Whether birth weight predicts later sedentary time in humans is uncertain.OBJECTIVES: We examined the relation between birth weight and sedentary time in youth and examined whether this association was mediated by central adiposity.DESIGN: We used pooled cross-sectional data from 8 observational studies conducted between 1997 and 2007 that consisted of 10,793 youth (boys: 47%) aged 6-18 y from the International Children's Accelerometry Database. Birth weight was measured in hospitals or maternally reported, sedentary time was assessed by using accelerometry (<100 counts/min), and abdominal adiposity (waist circumference) was measured according to WHO procedures. A mediation analysis with bootstrapping was used to analyze data.RESULTS: The mean (±SD) time spent sedentary was 370 ± 91 min/d. Birth weight was positively associated with sedentary time (B = 4.04, P = 0.006) and waist circumference (B = 1.59, P < 0.001), whereas waist circumference was positively associated with sedentary time (B = 0.82, P < 0.001). Results of the mediation analysis showed a significant indirect effect of birth weight on sedentary time through waist circumference (B: 1.30; 95% bias-corrected CI: 0.94, 1.72), and when waist circumference was controlled for, the effect of birth weight on sedentary time was attenuated by 32% (B = 2.74, P = 0.06).CONCLUSION: The association between birth weight and sedentary time appears partially mediated by central adiposity, suggesting that both birth weight and abdominal adiposity may be correlates of sedentary time in youth.

AB - BACKGROUND: Birth weight is an early correlate of disease later in life, and animal studies suggest that low birth weight is associated with reduced activity and increased sedentary time. Whether birth weight predicts later sedentary time in humans is uncertain.OBJECTIVES: We examined the relation between birth weight and sedentary time in youth and examined whether this association was mediated by central adiposity.DESIGN: We used pooled cross-sectional data from 8 observational studies conducted between 1997 and 2007 that consisted of 10,793 youth (boys: 47%) aged 6-18 y from the International Children's Accelerometry Database. Birth weight was measured in hospitals or maternally reported, sedentary time was assessed by using accelerometry (<100 counts/min), and abdominal adiposity (waist circumference) was measured according to WHO procedures. A mediation analysis with bootstrapping was used to analyze data.RESULTS: The mean (±SD) time spent sedentary was 370 ± 91 min/d. Birth weight was positively associated with sedentary time (B = 4.04, P = 0.006) and waist circumference (B = 1.59, P < 0.001), whereas waist circumference was positively associated with sedentary time (B = 0.82, P < 0.001). Results of the mediation analysis showed a significant indirect effect of birth weight on sedentary time through waist circumference (B: 1.30; 95% bias-corrected CI: 0.94, 1.72), and when waist circumference was controlled for, the effect of birth weight on sedentary time was attenuated by 32% (B = 2.74, P = 0.06).CONCLUSION: The association between birth weight and sedentary time appears partially mediated by central adiposity, suggesting that both birth weight and abdominal adiposity may be correlates of sedentary time in youth.

U2 - 10.3945/ajcn.114.103648

DO - 10.3945/ajcn.114.103648

M3 - Journal article

C2 - 25832337

VL - 101

SP - 983

EP - 990

JO - The American Journal of Clinical Nutrition

JF - The American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -