Assessment of Total-Body Atherosclerosis by PET/Computed Tomography

Poul Flemming Høilund-Carlsen; Reza Piri; Oke Gerke; Lars Edenbrandt; Abass Alavi

doi:10.1016/j.cpet.2020.09.013

Assessment of Total-Body Atherosclerosis by PET/Computed Tomography

Poul Flemming Høilund-Carlsen^*, Reza Piri, Oke Gerke, Lars Edenbrandt, Abass Alavi

^*Corresponding author for this work

KI, Clinical Physiology and Nuclear Medicine

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Atherosclerotic burden has become the focus of cardiovascular risk assessment. PET/computed tomography (CT) imaging with the tracers 18F-fluorodeoxyglucose and 18F-sodium fluoride shows arterial wall inflammation and microcalcification, respectively. Arterial uptake of both tracers is modestly age dependent. 18F-sodium fluoride uptake is consistently associated with risk factors and more easily measured in the heart. Because of extremely high sensitivity, ultrashort acquisition, and minimal radiation to the patient, total-body PET/CT provides unique opportunities for atherosclerosis imaging: disease screening and delayed and repeat imaging with global disease scoring and parametric imaging to better characterize the atherosclerosis of individual patients.

Original language	English
Journal	P E T Clinics
Volume	16
Issue number	1
Pages (from-to)	119-128
ISSN	1556-8598
DOIs	https://doi.org/10.1016/j.cpet.2020.09.013
Publication status	Published - Jan 2021

Keywords

Atherosclerosis
Calcification
FDG
Inflammation
NaF
PET/CT
Total body

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10.1016/j.cpet.2020.09.013

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Accepted manuscript, 679 KB
Licence: CC BY-NC-ND
Embargo ends: 18/11/2021

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title = "Assessment of Total-Body Atherosclerosis by PET/Computed Tomography",

abstract = "Atherosclerotic burden has become the focus of cardiovascular risk assessment. PET/computed tomography (CT) imaging with the tracers 18F-fluorodeoxyglucose and 18F-sodium fluoride shows arterial wall inflammation and microcalcification, respectively. Arterial uptake of both tracers is modestly age dependent. 18F-sodium fluoride uptake is consistently associated with risk factors and more easily measured in the heart. Because of extremely high sensitivity, ultrashort acquisition, and minimal radiation to the patient, total-body PET/CT provides unique opportunities for atherosclerosis imaging: disease screening and delayed and repeat imaging with global disease scoring and parametric imaging to better characterize the atherosclerosis of individual patients.",

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AU - Høilund-Carlsen, Poul Flemming

AU - Piri, Reza

AU - Gerke, Oke

AU - Edenbrandt, Lars

AU - Alavi, Abass

PY - 2021/1

Y1 - 2021/1

N2 - Atherosclerotic burden has become the focus of cardiovascular risk assessment. PET/computed tomography (CT) imaging with the tracers 18F-fluorodeoxyglucose and 18F-sodium fluoride shows arterial wall inflammation and microcalcification, respectively. Arterial uptake of both tracers is modestly age dependent. 18F-sodium fluoride uptake is consistently associated with risk factors and more easily measured in the heart. Because of extremely high sensitivity, ultrashort acquisition, and minimal radiation to the patient, total-body PET/CT provides unique opportunities for atherosclerosis imaging: disease screening and delayed and repeat imaging with global disease scoring and parametric imaging to better characterize the atherosclerosis of individual patients.

AB - Atherosclerotic burden has become the focus of cardiovascular risk assessment. PET/computed tomography (CT) imaging with the tracers 18F-fluorodeoxyglucose and 18F-sodium fluoride shows arterial wall inflammation and microcalcification, respectively. Arterial uptake of both tracers is modestly age dependent. 18F-sodium fluoride uptake is consistently associated with risk factors and more easily measured in the heart. Because of extremely high sensitivity, ultrashort acquisition, and minimal radiation to the patient, total-body PET/CT provides unique opportunities for atherosclerosis imaging: disease screening and delayed and repeat imaging with global disease scoring and parametric imaging to better characterize the atherosclerosis of individual patients.

KW - Atherosclerosis

KW - Calcification

KW - FDG

KW - Inflammation

KW - NaF

KW - PET/CT

KW - Total body

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DO - 10.1016/j.cpet.2020.09.013

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