Assessment of Total-Body Atherosclerosis by PET/Computed Tomography

Poul Flemming Høilund-Carlsen*, Reza Piri, Oke Gerke, Lars Edenbrandt, Abass Alavi

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Atherosclerotic burden has become the focus of cardiovascular risk assessment. PET/computed tomography (CT) imaging with the tracers 18F-fluorodeoxyglucose and 18F-sodium fluoride shows arterial wall inflammation and microcalcification, respectively. Arterial uptake of both tracers is modestly age dependent. 18F-sodium fluoride uptake is consistently associated with risk factors and more easily measured in the heart. Because of extremely high sensitivity, ultrashort acquisition, and minimal radiation to the patient, total-body PET/CT provides unique opportunities for atherosclerosis imaging: disease screening and delayed and repeat imaging with global disease scoring and parametric imaging to better characterize the atherosclerosis of individual patients.

Original languageEnglish
JournalP E T Clinics
Issue number1
Pages (from-to)119-128
Publication statusPublished - Jan 2021


  • Atherosclerosis
  • Calcification
  • FDG
  • Inflammation
  • NaF
  • PET/CT
  • Total body


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