Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome?

B Benyamin, T I A Sørensen, K Schousboe, M Fenger, P M Visscher, Kirsten Ohm Kyvik

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

AIMS/HYPOTHESIS: The cluster of obesity, insulin resistance, dyslipidaemia and hypertension, called the metabolic syndrome, has been suggested as a risk factor for cardiovascular disease and type 2 diabetes. The aim of the present study was to evaluate whether there are common genetic and environmental factors influencing this cluster in a general population of twin pairs. MATERIALS AND METHODS: A multivariate genetic analysis was performed on nine endophenotypes associated with the metabolic syndrome from 625 adult twin pairs of the GEMINAKAR study of the Danish Twin Registry. RESULTS: All endophenotypes showed moderate to high heritability (0.31-0.69) and small cial environmental background
Original languageEnglish
JournalDiabetologia
Volume50
Issue number9
Pages (from-to)1880-1888
Number of pages9
ISSN0012-186X
DOIs
Publication statusPublished - 1. Sep 2007

Keywords

  • Adult
  • Aged
  • Blood Pressure
  • Body Mass Index
  • Environment
  • Female
  • Humans
  • Insulin Resistance
  • Lipids
  • Lipoproteins
  • Male
  • Metabolic Syndrome X
  • Middle Aged
  • Obesity
  • Phenotype
  • Twins, Dizygotic
  • Twins, Monozygotic

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