Archaea oxidizing alkanes through alkyl-coenzyme M reductases

Florin Musat*, Kasper Urup Kjeldsen, Amelia-Elena Rotaru, Song-Can Chen, Niculina Musat

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewResearchpeer-review

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Abstract

This review synthesizes recent discoveries of novel archaea clades capable of oxidizing higher alkanes, from volatile ones like ethane, to longer-chain alkanes like hexadecane. These archaea, termed anaerobic multicarbon alkane-oxidizing archaea (ANKA), initiate alkane oxidation using alkyl-coenzyme M reductases, enzymes similar to the methyl-coenzyme M reductases of methanogenic and anaerobic methanotrophic archaea (ANME). The alkane-oxidizing archaea group (ALOX), encompassing ANME and ANKA, harbor increasingly complex alkane degradation pathways, correlated with the alkane chain length. We discuss the evolutionary trajectory of these pathways emphasizing metabolic innovations and the acquisition of metabolic modules via lateral gene transfer. Additionally, we explore the mechanisms by which archaea couple alkane oxidation with the reduction of electron acceptors, including electron transfer to partner sulfate-reducing bacteria. The phylogenetic and functional constraints that shape ALOX-SRB associations are also discussed. We conclude by highlighting the research needs in this emerging research field, and its potential applications in biotechnology.
Original languageEnglish
Article number102486
JournalCurrent Opinion in Microbiology
Volume79
Number of pages9
ISSN1369-5274
DOIs
Publication statusPublished - Jun 2024

Keywords

  • Alkanes/metabolism
  • Archaea/enzymology
  • Archaeal Proteins/metabolism
  • Bacteria/enzymology
  • Electron Transport
  • Gene Transfer, Horizontal
  • Oxidation-Reduction
  • Oxidoreductases/metabolism
  • Phylogeny

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