Applications of Artificial Intelligence for Metastatic Gastrointestinal Cancer: A Systematic Literature Review

Amin Naemi*, Ashkan Tashk, Amir Sorayaie Azar, Tahereh Samimi, Ghanbar Tavassoli, Anita Bagherzadeh Mohasefi, Elaheh Nasiri Khanshan, Mehrdad Heshmat Najafabad, Vafa Tarighi, Uffe Kock Wiil, Jamshid Bagherzadeh Mohasefi, Habibollah Pirnejad, Zahra Niazkhani

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Background/Objectives: This systematic literature review examines the application of Artificial Intelligence (AI) in the diagnosis, treatment, and follow-up of metastatic gastrointestinal cancers. Methods: The databases PubMed, Scopus, Embase (Ovid), and Google Scholar were searched for published articles in English from January 2010 to January 2022, focusing on AI models in metastatic gastrointestinal cancers. Results: forty-six studies were included in the final set of reviewed papers. The critical appraisal and data extraction followed the checklist for systematic reviews of prediction modeling studies. The risk of bias in the included papers was assessed using the prediction risk of bias assessment tool. Conclusions: AI techniques, including machine learning and deep learning models, have shown promise in improving diagnostic accuracy, predicting treatment outcomes, and identifying prognostic biomarkers. Despite these advancements, challenges persist, such as reliance on retrospective data, variability in imaging protocols, small sample sizes, and data preprocessing and model interpretability issues. These challenges limit the generalizability, clinical application, and integration of AI models.
Original languageEnglish
Article number558
JournalCancers
Volume17
Issue number3
Number of pages23
ISSN2072-6694
DOIs
Publication statusPublished - 6. Feb 2025

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